The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma

Benhamou, Yordan; Picco, Vincent; Pagès, Gilles

doi:10.1016/j.oraloncology.2016.04.006

Cited by 16 publications

(8 citation statements)

References 85 publications

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“…It is one of the 10 most common cancers in the world, and 90% of oral cancer cases are oral squamous cell carcinoma (OSCC) [1]. Surgery, radiation therapy and coadjutant therapy are common approaches used in the treatment of OSCC [2].…”

Section: Introductionmentioning

confidence: 99%

Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma

Wang

Deng

Zhang

et al. 2017

Cell Physiol Biochem

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Background/Aims: Zinc finger protein 703 (ZNF703), initially identified as a novel oncogene in human breast cancer, is a member of the NET/NlZ family of zinc finger transcription factors. It is recognized that the overexpression of ZNF703 is associated with various types of human cancers, but the role and molecular mechanism of ZNF703 in oral squamous cell carcinoma (OSCC) are unknown. Methods: ZNF703 expression levels were examined in OSCC tissues and non-cancerous tissues by qRT-PCR and immunohistochemistry (IHC). The molecular mechanisms of ZNF703 and its effects on cell growth and metastasis were explored in vitro and in vivo using the CCK8 assay, colony formation assay, cell cycle analysis, migration and invasion assays, wound-healing assay, western blotting and xenograft experiments in nude mice. Results: In this study, ZNF703 was found to be upregulated in OSCC tissues compared to that in normal tissues at both mRNA and protein levels, and its expression level was closely correlated with the overall survival of patients with OSCC. Silencing of the ZNF703 gene in OSCC cells significantly inhibited cell growth and metastasis in vitro and in vivo. Conversely, the overexpression of ZNF703 in OSCC cells promoted cancer growth and metastasis in vitro. Mechanistically, ZNF703 activated the PI3K/AKT/GSK-3β signalling pathway and its downstream effectors, thus regulating the cell cycle and epithelial-mesenchymal transition (EMT). Furthermore, the promotive effects of ZNF703 on cellular proliferation and metastasis could be rescued by LY294002 (a PI3K-specific inhibitor) and MK2206 (an Akt-specific inhibitor). Conclusion: The results show that ZNF703 promotes cell growth and metastasis through PI3K/Akt/GSK-3β signalling in OSCC and that it may be a promising target in the treatment of patients with OSCC.

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Section: Introductionmentioning

confidence: 99%

Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma

Wang

Deng

Zhang

et al. 2017

Cell Physiol Biochem

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“…While surgical resection and treatment of BSCC has improved, prognosis remains poor for patients, in part due to the recurrence rate [ 15 ]. Buccal carcinoma has a higher recurrence rate and a lower 5-year survival than other oral cancers [ 6 , 16 ]. Studies have suggest that the absecne of relatively fixed anatomic barriers that do not have enough limiting effect on primary tumor growth and spread account for the recurrence rate [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Unit resection of buccal squamous cell carcinoma: Description of a new surgical technique

Ren

Gong

2016

Oncotarget

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This study characterized the infiltration of primary tumors along the muscles, fascia and spaces of the maxillofacial region in buccal squamous cell carcinoma (BSCC) and suggested a new surgical strategy that is suitable for most stages. Based on the anatomic characteristics and infiltration of the primary tumor a new surgical approach - unit resection buccal surgery (URBS) - was developed. We evaluated this new surgical strategy, across a cohort of 127 BSCCs: 60 cases treated with URBS and 67 cases treated with conventional surgery. Notably there was no statistical difference in the clinicopathological variables between the two groups. After initial treatment with curative intent, the patients were regularly followed-up with clinical examination and imaging. URBS proved suitable for almost all stages of BSCC, and was particularly advantageous for advanced stages of BSCC. At 2 years post-treatment, the rates of overall survival were 83.3% in the URBS group and 60.1% in the conventional surgery group, respectively (hazard ratio 0.38; 95% CI 0.20 to 0.75; P=0.005). Similarly, the rates of disease-free survival were 76.6% and 51.9% in the URBS group and the conventional surgery group, respectively (hazard ratio 0.42; 95% CI 0.23 to 0.75; P=0.003). The principles of URBS are suitable for almost all stages of BSCC, especially advanced stages. URBS may improve the prognosis of BSCC patients.

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“…The TNM staging system in head and neck squamous cell carcinoma (SCC), including oral SCC, is reported to be unable to predict the survival outcomes of patients at the same stage ( 2 – 4 ). Numerous studies have researched the prognostic parameters of oral SCC using various approaches, including clinical and pathological procedures ( 5 – 8 ). The pathological tumor volume (PTV) of the primary tumor is calculated after surgical resection by measuring its diameters in three dimensions ( 9 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma

et al. 2018

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The present study examined whether the pathological tumor volume (PTV) was correlated with the survival outcomes in patients with oral squamous cell carcinoma (SCC) and clinical lymph node metastasis. Forty-seven patients who underwent radical surgery without preoperative treatment were enrolled. The PTV of the primary tumor, which was surgically resected without preoperative treatment, was calculated based on the diameters in three dimensions. A survival analysis was performed using a Cox proportional hazards model. A PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01) in a univariate analysis. A multivariate analysis with adjustment for the pathological stage (stage I–II/III–IV), primary site (tongue/others) and positive surgical margin and/or extracapsular extension (absent/present) showed that a PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01). The present findings suggested that PTV in oral SCC provides a prognostic parameter that may predict shorter or longer overall and local recurrence-free survival.

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The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma

Cited by 16 publications

References 85 publications

Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma

Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3K/AKT/GSK-3β Signalling in Oral Squamous Cell Carcinoma

Unit resection of buccal squamous cell carcinoma: Description of a new surgical technique

Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma

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