The tegument of <i>Schistosoma mansoni</i>: functional and immunological features

Abath, Frederico G. C.; Werkhauser, Roberto C.

doi:10.1046/j.1365-3024.1996.d01-6.x

Cited by 78 publications

(52 citation statements)

References 21 publications

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“…The tegument is an important interface between S. mansoni and its environment in the host because adult worms perform adjustable mechanisms for their survival and resistance to immune response (Abath & Werkhauser 1996). No information is available concerning a presumed correlation between thickness of the tegument and physiological conditions of the host.…”

Section: Discussionmentioning

confidence: 99%

Morphological aspects of Schistosoma mansoni adult worms isolated from nourished and undernourished mice: a comparative analysis by confocal laser scanning microscopy

Neves

Machado-Silva

Pelajo-Machado³

et al. 2001

Mem. Inst. Oswaldo Cruz

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Malnutrition hampers the course of schistosomiasis mansoni infection just as normal growth of adultKey words: Schistosoma mansoni -undernutrition -confocal scanning laser microscopy Schistosomiasis is a very widespread disease in the developing world and is one of the most important helminth infections. Malnutrition and schistosomiasis mansoni are both serious publichealth problems in Northeast Brazil and often overlap in the same geographical area (Coutinho et al. 1997a). Meanwhile, the role played by the nutritional status of the host on the development of schistosomiasis and vice versa is not clearly understood (Ferreira & Coutinho 1999

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Section: Discussionmentioning

confidence: 99%

Morphological aspects of Schistosoma mansoni adult worms isolated from nourished and undernourished mice: a comparative analysis by confocal laser scanning microscopy

Neves

Machado-Silva

Pelajo-Machado³

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…The parasitic worm Schistosoma mansoni Sambon, 1907 has been shown to acquire an extensive range of host antigens that are subsequently expressed on the parasite tegument (Abath & Werkhauser 1996). Study of the development of the myxozoan parasite Myxobolus pendula Guilford, 1966 has shown an association of the growth of parasitederived cysts with degradation of host connective tissue and remodelling of fibrillar collagen (Martyn et al 2002).…”

Section: Laboratory Maintenance Ofmentioning

confidence: 99%

Sequential development of Buddenbrockia plumatellae (Myxozoa: Malacosporea) within Plumatella repens (Bryozoa: Phylactolaemata)

McGurk¹,

Morris²,

Adams³

2006

Dis. Aquat. Org.

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Colonies of the freshwater bryozoan Plumatella repens collected from a river in the UK were found to be infected with the myxozoan parasite Buddenbrockia plumatellae following laboratory maintenance. Optimisation of the bryozoan diet allowed maintenance of infected colonies for 90 d, permitting observation by light and electron microscopy of the sequential parasitic developmental cycle. Parasite stages were associated with host peritoneum, identifying the primary developmental phase. The association of B. plumatellae cells with peritoneal basal lamina and morphological similarities between parasite and host suggested that the parasite remodelled host tissue. Progressive expansion and elongation of individual parasites led to the release of freely floating vermiform stages within the host coelomic cavities. Within these 'worms', intraluminal masses developed, resulting in the formation of spores. Upon maturation, the 'worms' ruptured, releasing many spores within the host that were subsequently discharged. Although parasitism led to increased bryozoan fragmentation and lowered statoblast production, some colonies did survive, resulting in repeated waves of infection. Long-term laboratory maintenance of infected bryozoan colonies could provide a means of maintaining B. plumatellae for study until the full life cycle is ascertained.KEY WORDS: Myxozoa · Malacosporea · Bryozoa · Buddenbrockia plumatellae · Development · Remodel Resale or republication not permitted without written consent of the publisherDis Aquat Org 73: [159][160][161][162][163][164][165][166][167][168][169] 2006 focused on the development of B. plumatellae in populations of P. fungosa, Hyalinella punctata Hancock and Fredericella sultana Blumenbach (Canning et al. 2002). However, some details of the developmental cycle within bryozoans remained to be revealed; in particular, the presence of stages preceding coelozoic 'worm' development. Despite contrasting morphologies, molecular evidence led to a proposed synonymy of B. plumatellae and T. bryozoides (Monteiro et al. 2002), with the former name assuming historical precedence.The aim of the present study was to examine developmental stages of Buddenbrockia plumatellae within individual specimens of Plumatella repens. Repeated examination by light microscopy allowed the first description of prolonged sequential development in living hosts. Ultrastructural analysis of infected bryozoan tissue gave further insights into the morphological characteristics of the interaction between this unusual myxozoan parasite and host. MATERIALS AND METHODS Collection and observation of bryozoan colonies.In June 2002, floating branches and areas of plastic sheeting were collected from various locations in the River Avon, Wiltshire, UK (51°00' 09'' N, 1°44' 41'' W). These were examined grossly using a ×10 hand lens for bryozoans. Bryozoan colonies were transported in aerated plastic containers to the laboratory in Stirling, where they were attached to Petri dishes and maintained at 21°C on a diet of alga...

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“…In addition, it plays a vital role in acquisition of host derived nutrients, including carbohydrates, amino acids, and lipids (Abath & Werkhauser 1996, Jones et al 2004. Along with other key molecules, tegument associated antigens of schistosomes have been investigated as targets of protective immune responses in murine hosts and for defining antibody and cytokine correlates of apparent resistance and susceptibility in human populations, a key approach to establishing the protective potential of a vaccine candidate (Ribeiro de Jesus et al 2000, Acosta et al 2002, Al-Sherbiny et al 2003, McManus & Bartley 2004, Bergquist et al 2005.…”

Section: Discussionmentioning

confidence: 99%

Recombinant tegumental protein Shistosoma japonicum very lowdensity lipoprotein binding protein as a vaccine candidate against Schistosoma japonicum

Gan

Shen

Wang

et al. 2006

Mem. Inst. Oswaldo Cruz

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A polyhistidine-tagged recombinant tegumental protein Schistosoma japonicum very lowdensity lipoprotein binding protein (SVLBP) from adult Schistosoma japonicum was expressed in Escherichia coli. The affinity purified rSVLBP was used to vaccinate mice. The worm numbers and egg deposition recovered from the livers and veins of the immunized mice were 33.5% and 47.6% less than that from control mice, respectively (p<0.05). There was also a marked increase in the antibody response in vaccinated mice: the titer of IgG1 and IgG2a, IgG2b in the vaccinated group was significantly higher than that in the controls (>1:6,400 in total IgG). In a comparison of the reactivity of sera from healthy individuals and patients with rSVLBP, recognition patterns against this parasite tegumental antigen varied among different groups of the individuals. Notably, the average titres of anti-rSVLBP antibody in sera from faecal egg-negative individuals was significantly higher than that in sera from the faecal egg-positives, which may be reflect SVLBP-specific protection. These results suggested that the parasite tegumental protein SVLBP was a promising candidate for further investigation as a vaccine antigen for use against Asian schistosomiasis

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The tegument of Schistosoma mansoni: functional and immunological features

Cited by 78 publications

References 21 publications

Morphological aspects of Schistosoma mansoni adult worms isolated from nourished and undernourished mice: a comparative analysis by confocal laser scanning microscopy

Morphological aspects of Schistosoma mansoni adult worms isolated from nourished and undernourished mice: a comparative analysis by confocal laser scanning microscopy

Sequential development of Buddenbrockia plumatellae (Myxozoa: Malacosporea) within Plumatella repens (Bryozoa: Phylactolaemata)

Recombinant tegumental protein Shistosoma japonicum very lowdensity lipoprotein binding protein as a vaccine candidate against Schistosoma japonicum

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