“…T h e first problem in developing this use of the anhepatic pig was that the pig (Terblanche, Peacock, Bowes, and Hobbs, 1968)~ like the calf (Battersby, Balderson, Winch, and Burnett, 1971)~ but unlike the monkey (Milnes and Child, 1949) or man (Starzl, Groth, Brettschneider, Penn, Fulginiti, Moon, Blandshard, Martin, and Porter, 1968)~ will not survive acute ligation of the portal vein. Prehepatectomy portacaval shunt would not provide a drainage for the portal system, for in the pig the inferior vena cava passes through the liver, thus necessitating removal of a long section of the vena cava during hepatectomy.…”