The technique of orthotopic liver homotransplantation in the pig

A model which can be used to improve the treatment of acute hepatic failure

“…T h e first problem in developing this use of the anhepatic pig was that the pig (Terblanche, Peacock, Bowes, and Hobbs, 1968)~ like the calf (Battersby, Balderson, Winch, and Burnett, 1971)~ but unlike the monkey (Milnes and Child, 1949) or man (Starzl, Groth, Brettschneider, Penn, Fulginiti, Moon, Blandshard, Martin, and Porter, 1968)~ will not survive acute ligation of the portal vein. Prehepatectomy portacaval shunt would not provide a drainage for the portal system, for in the pig the inferior vena cava passes through the liver, thus necessitating removal of a long section of the vena cava during hepatectomy.…”

The Role of A-O-Incompatible Blood Transfusions in Porcine Orthotopic Liver Transplantations

“…Only a few groups, working in the field of experimental transplantations, matched their donors and recipients for compatible blood groups [5,7,8].…”

Liver Transplantation in Swine without Venovenous Bypass

“…In this course different surgical techniques for the recipient operation have been specified. However, due to particularly swine's cardiocirculatory sensitivity, even during the anhepatic and warm ischemic period most of the groups are using a venovenous bypass to avoid cardiac impact [7][8][9] . Especially in swine a total disruption of the venous backflow to the heart as well as the portal back pressure due to obstruction of the portal vein during hepatectomy lead to serious hemodynamic interference.…”