The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1

Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA‐binding protein and a novel transcriptional activator, TIP120

“…TBP is one of the GTFs required for all eukaryotic RNA polymerases (Sharp 1992;Hernandez 1993). The multisubunit GTFs such as SL1, TFIID, and TFIIIB are composed of TBP and TBP-associated factors for RNA polymerase I, II, and III, respectively (Comai et al 1992;Taggart et al 1992;Hisatake et al 1993;Hoey et al 1993;Ruppert et al 1993). Various polypeptides, including the GTFs and cellular and viral transactivators interact directly with TBP and play a role in transcriptional regulation (Hernandez 1993).…”

The dual role of helix – loop – helix-zipper protein USF in ribosomal RNA gene transcription in vivo

“…Similarly, trans-acting factors that speci®cally interact with the cis-acting elements are required for the initiation and/or regulation of rDNA transcription. A complex called SL1 that consists of TATA box-binding protein TBP and pol I-speci®c TBP-associated proteins (TAFs) constitutes one of the essential trans-acting factors involved in the initiation of rDNA transcription (Comai et al, 1992). Recent study has suggested the potential involvement of other factors in the initiation of rDNA transcription (Joost et al, 1994).…”

DNA methylation in the promoter of ribosomal RNA genes in human cells as determined by genomic sequencing

“…Since the three different eukaryotic RNA polymerases share certain protein components and transcription factors [3][4][5][6][7], DNA methylation might also have a function in the control of RNA polymerase I-transcribed genes. We have analyzed deoxycytidine methylation in the promoter region of the RNA polymerase I-transcribed ribosomal RNA genes in different primary human cells, in primary human tumor cells, and in human cell lines.…”