The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2

Ren, Jinfeng; Shen, Shun; Wang, Dangge; Xi, Zhangjie; Guo, Le‐Hang; Pang, Zhiqing; Qian, Yong; Sun, Xuejian; Jiang, Xinguo

doi:10.1016/j.biomaterials.2012.01.025

Cited by 351 publications

(182 citation statements)

References 43 publications

Supporting

Mentioning

176

Contrasting

Order By: Relevance

“…For this purpose, a broad range of nanoparticles with different sizes, architectures, and surface properties have been engineered for brain drug delivery. 27,28 These include liposomes, 29,30 polymeric nanoparticles, 31,32 carbon nanotubes, 33,34 nanofibers, 35,36 dendrimers, 37,38 micelles, 39 inorganic nanoparticles made of iron oxide, 40 and gold nanoparticles. 41 Unfortunately, it is beyond the scope of this article to review potential advantages -or disadvantages -of each of these nanocarriers in the imaging and/or therapy of the brain.…”

Section: Introductionmentioning

confidence: 99%

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira

Gamarra

2016

IJN

324

232

View full text Add to dashboard Cite

This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.

show abstract

Section: Introductionmentioning

confidence: 99%

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira

Gamarra

2016

IJN

324

232

View full text Add to dashboard Cite

show abstract

“…Fe@MWCNTs offer versatility of physicochemical modifications and biocompatibility, and they have already gained prominence due to their efficiency in crossing the blood-brain barrier. 49 Nevertheless, there are several factors that should be taken into account while proposing CNT candidates for applications as MRI CAs. One of the most important ones is effectiveness of relaxation in a given strength of magnetic field.…”

Section: Resultsmentioning

confidence: 99%

Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

Kuźnik¹,

Tomczyk²,

Wyskocka³

et al. 2015

IJN

View full text Add to dashboard Cite

Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N -phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe 3+ ions. The new hybrids – Fe(III)/Fe@(f-/O-)MWCNTs – containing 6%–14% of the “tethered” Fe 3+ ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r 2 =63.9±0.9 mL mg −1 s −1 was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r 2 =57.9±2.9 mL mg −1 s −1 , the highest impact of the anchored Fe(III) ions was observed. The T 1 / T 2 ratio of 30–100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T 2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet–visible spectrophotometry.

show abstract

“…[8][9][10] Encapsulation of siRNA in nanoparticles is particularly beneficial as the siRNA relies on protection from degradation by ubiquitous nucleases in the bloodstream and has a high molecular weight and negative charge that disfavors passive cellular uptake of naked siRNA. 11,12 Through electrostatic interactions with positively charged synthetic materials, such as cationic lipids, siRNA can be complexed in the interior of a nanoparticle thereby obtaining protection from degradation during systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Bruun¹,

Larsen²,

Jølck³

et al. 2015

IJN

View full text Add to dashboard Cite

Clinical applications of siRNA for treating disorders in the central nervous system require development of systemic stable, safe, and effective delivery vehicles that are able to cross the impermeable blood–brain barrier (BBB). Engineering nanocarriers with low cellular interaction during systemic circulation, but with high uptake in targeted cells, is a great challenge and is further complicated by the BBB. As a first step in obtaining such a delivery system, this study aims at designing a lipid nanoparticle (LNP) able to efficiently encapsulate siRNA by a combination of titratable cationic lipids. The targeted delivery is obtained through the design of a two-stage system where the first step is conjugation of angiopep to the surface of the LNP for targeting the low-density lipoprotein receptor-related protein-1 expressed on the BBB. Second, the positively charged LNPs are masked with a negatively charged PEGylated (poly(ethylene glycol)) cleavable lipopeptide, which contains a recognition sequence for matrix metalloproteinases (MMPs), a class of enzymes often expressed in the tumor microenvironment and inflammatory BBB conditions. Proteolytic cleavage induces PEG release, including the release of four glutamic acid residues, providing a charge switch that triggers a shift of the LNP charge from weakly negative to positive, thus favoring cellular endocytosis and release of siRNA for high silencing efficiency. This work describes the development of this two-stage nanocarrier-system and evaluates the performance in brain endothelial and glioblastoma cells with respect to uptake and gene silencing efficiency. The ability of activation by MMP-triggered dePEGylation and charge shift is demonstrated to substantially increase the uptake and the silencing efficiency of the LNPs.

show abstract

The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2

Cited by 351 publications

References 43 publications

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Contact Info

Product

Resources

About

The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2

Cited by 351 publications

References 43 publications

Getting into the brain: liposome-based strategies for effective drug delivery across the blood&ndash;brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood&ndash;brain barrier

Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

Investigation of enzyme-sensitive lipid&nbsp;nanoparticles for delivery of siRNA to blood&ndash;brain barrier and glioma cells

Contact Info

Product

Resources

About

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells