The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Bjedov, Ivana; Rallis, Charalampos

doi:10.3390/genes11091043

Cited by 66 publications

(50 citation statements)

References 196 publications

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“…These fatty acids have been reported to inhibit the mammalian (or mechanistic) target of rapamycin (mTOR) in animal studies showing benefits in cancer 34 , metabolic syndrome 35 , spinal cord injury 36 , and depression 37 . mTOR inhibition extends lifespan in many species 38 and acts as an energy sensor to coordinate gene expression, ribosome biogenesis, and mitochondrial metabolism 39 . In the Heart and Soul Study, where whole blood EPA + DHA levels were inversely associated with all-cause mortality 24 , higher levels were also linked with a slower rate of telomere shortening over a 5-year period 40 .…”

Section: Discussionmentioning

confidence: 99%

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Harris

Tintle²,

Imamura³

et al. 2021

Nat Commun

140

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The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

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Section: Discussionmentioning

confidence: 99%

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Harris

Tintle²,

Imamura³

et al. 2021

Nat Commun

140

View full text Add to dashboard Cite

show abstract

“…The cells were continually incubated for six days, and the medium was replaced every two days by a new serum-free DMEM containing doses of samples or DMSO (0.5%). Rapamycin inhibits the mTOR signaling pathway and has beneficial effects on the health span and lifespan of all cellular and organism systems [ 27 ]. Therefore, rapamycin was used as a positive control in the experiment.…”

Section: Methodsmentioning

confidence: 99%

Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction

Pan

Liu

Fujii

et al. 2021

Oxidative Medicine and Cellular Longevity

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The antiaging benzoquinone-type molecule ehretiquinone was isolated in a previous study as a leading compound from the herbal medicine Onosma bracteatum wall. This paper reports the antiaging effect and mechanism of ehretiquinone by using yeasts, mammal cells, and mice. Ehretiquinone extends not only the replicative lifespan but also the chronological lifespan of yeast and the yeast-like chronological lifespan of mammal cells. Moreover, ehretiquinone increases glutathione peroxidase, catalase, and superoxide dismutase activity and reduces reactive oxygen species and malondialdehyde (MDA) levels, contributing to the lifespan extension of the yeasts. Furthermore, ehretiquinone does not extend the replicative lifespan of Δsod1, Δsod2, Δuth1, Δskn7, Δgpx, Δcat, Δatg2, and Δatg32 mutants of yeast. Crucially, ehretiquinone induces autophagy in yeasts and mice, thereby providing significant evidence on the antiaging effects of the molecule in the mammalian level. Concomitantly, the silent information regulator 2 gene, which is known for its contributions in prolonging replicative lifespan, was confirmed to be involved in the chronological lifespan of yeasts and participates in the antiaging activity of ehretiquinone. These findings suggest that ehretiquinone shows an antiaging effect through antioxidative stress, autophagy, and histone deacetylase Sir2 regulation. Therefore, ehretiquinone is a promising molecule that could be developed as an antiaging drug or healthcare product.

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“…Experimental studies of aging have shown that genes that influence aging phenotypes and longevity are also involved in resilience. The most studied pathways are those from insulin and insulin-like growth factor-1 (IGF-1), protein-kinases (AKT), FOXO transcription factors, complex mTOR (a target of rapamycin), p16 cell cycle inhibitor, and sirtuins (S6K), which all jointly decide outcomes of cell responses to stress and damage by influencing cell survival, growth, DNA repair, apoptosis, cellular senescence and autophagy (Table 3) [44,45]. Emerging approaches in measuring age-related resilience include measuring how quickly and completely an individual recovers from acute stress, such as a hip fracture.…”

Section: The Intersection Between Psychological and Biological Resilience In Older Individuals-significance For Successful Agingmentioning

confidence: 99%

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

Majnarić

Bosnić

Guljaš

et al. 2021

IJMS

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The term resilience, which has been present in science for almost half a century, stands for the capacity of some system needed to overcome an amount of disturbance from the environment in order to avoid a change to another stable state. In medicine, the concept of resilience means the ability to deal with daily stress and disturbance to our homeostasis with the intention of protecting it from disturbance. With aging, the organism becomes more sensitive to environmental impacts and more susceptible to changes. Mental disturbances and a decline in psychological resilience in older people are potentiated with many social and environmental factors along with a subjective perception of decreasing health. Distinct from findings in younger age groups, mental and physical medical conditions in older people are closely associated with each other, sharing common mechanisms and potentiating each other’s development. Increased inflammation and oxidative stress have been recognized as the main driving mechanisms in the development of aging diseases. This paper aims to reveal, through a translational approach, physiological and molecular mechanisms of emotional distress and low psychological resilience in older individuals as driving mechanisms for the accelerated development of chronic aging diseases, and to systematize the available information sources on strategies for mitigation of low resilience in order to prevent chronic diseases.

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The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Cited by 66 publications

References 196 publications

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

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