The Taqi Drd2 A1 Allele Is Associated With Alcohol-Dependence Although Its Effect Size Is Small

Berggren, Ulf; Fahlke, Claudia; Aronsson, Erik; Karanti, Aikaterini; Eriksson, Margaretha; Blennow, Kaj; Thelle, Dag S.; Zetterberg, Henrik; Balldin, Jan

doi:10.1093/alcalc/agl043

Cited by 69 publications

(54 citation statements)

References 14 publications

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“…The sample size in the present study may consequently have been too small to detect such a relationship. Furthermore, it has also been suggested that the Taq A1 allele is associated particularly with more severe forms of alcohol dependence [14,15] . In addition, it has been suggested that the Taq A1 SNP in DRD2 might reflect a familial form of alcoholism [46] , and thus not be suitable as a general susceptibility gene for alcoholism, even though the latter finding needs replication.…”

Section: Discussionmentioning

confidence: 99%

“…The SNP in the DRD2 (Taq A1 ) was chosen as this is the most studied marker for alcohol dependence [14,15] . For both the cholinergic and ghrelin signaling systems, the SNPs studied were chosen as haplotype-tagging SNPs covering 1 80% of the genetic variation in these genes.…”

Section: Genetic Markersmentioning

confidence: 99%

“…Alcohol-dependent individuals are reported to have reduced DA receptor D 2 (DRD 2 ) receptor sensitivity [10] , which appears to persist after several (7 8 6) years of sobriety [11] , as well as a reduced number of DRD 2 receptors [12] compared to controls. In addition, the Taq A1 allele of the dopamine receptor D 2 gene (DRD2) gene has been associated with alcohol dependence [13][14][15] .…”

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confidence: 99%

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Reward-Related Genes and Personality Traits in Alcohol-Dependent Individuals: A Pilot Case Control Study

Landgren

Berglund²,

Jerlhag³

et al. 2011

Neuropsychobiology

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Components of the brain reward system, i.e. the mesolimbic dopamine, laterodorsal cholinergic and ghrelin signaling systems, have been implicated in alcohol reward in preclinical studies. Genetic variants of these systems have previously been linked to alcohol dependence. Here, we genotyped 31 single nucleotide polymorphisms (SNPs): 1 SNP in the dopamine D₂ receptor (DRD2) gene, 20 SNPs in 5 different nicotinic acetylcholine receptor subunit (CHRN*) genes, and 10 SNPs in the genes encoding pro-ghrelin (GHRL) and its receptor (GHSR), in a pilot study of type 1 alcoholics (n = 84) and healthy controls (n = 32). These individuals were characterized using the Temperament and Character Inventory. None of the SNPs were associated with risk of alcohol dependence in this population. The GG genotype of SNP rs13261190 in the CHRNB3 was associated with increased novelty seeking, while SNPs of the ghrelin signaling system were associated with decreased self-directedness (AA of rs495225, GHSR) and alterations in self-transcendence (AA of both rs42451 and rs35680, GHRL). In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples.

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Section: Discussionmentioning

confidence: 99%

Section: Genetic Markersmentioning

confidence: 99%

mentioning

confidence: 99%

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Reward-Related Genes and Personality Traits in Alcohol-Dependent Individuals: A Pilot Case Control Study

Landgren

Berglund²,

Jerlhag³

et al. 2011

Neuropsychobiology

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“…One specific single nucleotide polymorphism (TaqI A, rs1800497 C-T) in the DRD2 has been examined in a large number of association studies for its relation with alcohol dependence or alcohol use, mainly with casecontrol designs in adults. Various studies have shown evidence for an association (for example, Berggren et al 16 and Foley et al, 17 see for meta-analyses Munafo et al 18 and Noble 19 ), whereas others have not. [20][21][22] Few of these studies have included adolescent samples.…”

Section: Introductionmentioning

confidence: 99%

Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction

et al. 2009

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Association studies investigating the link between the dopamine D2 receptor gene (DRD2) and alcohol (mis)use have shown inconsistent results. This may be due to lack of attention for environmental factors. High levels of parental rule-setting are associated with lower levels of adolescent alcohol use and delay of initiation of drinking. We tested whether DRD2 TaqI A (rs1800497) genotype interacts with alcohol-specific parenting practices in predicting the uptake of regular adolescent alcohol use. Non-regular drinkers were selected from a Dutch, nationwide sample of 428 adolescents (mean age 13.4 years at baseline) and participated in a prospective, community-based study with three annual waves. Parental rule-setting was directly and inversely related to adolescent alcohol use over time. For DRD2 genotype no significant main effect was found. DRD2 genotype interacted with parental rule-setting on adolescent alcohol use over time: adolescents, with parents highly permissive toward alcohol consumption and carrying a genotype with the DRD2 A1 (rs1800497T) allele, used significantly more alcohol over time than adolescents without these characteristics. The DRD2 genotype may pose an increased risk for alcohol use and abuse, depending on the presence of environmental risk factors, such as alcohol-specific parenting.

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“…Associations between alcohol dependence and genetic variants of alcoholmetabolizing enzymes and genes related to dopaminergic, GABAergic, glutamatergic, opioid, cholinergic, and serotonergic systems have been intensively investigated 4 . Dopamine is one of the most frequently studied neurotransmitters in addiction genetics, and the dopamine receptor D2 (DRD2) TaqI-A1 polymorphism was the first gene p o l y m o r p h i s m a s s o c i a t e d w i t h a l c o h o l dependence 5,6 . In their meta-analysis, Smith and colleagues reported that individuals with the A1A1 and A1A2 genotypes were 1.38 times more at risk for alcoholism than those with the A2A2 genotype 7 .…”

Section: Introductionmentioning

confidence: 99%

Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A Polymorphisms with Alcohol Dependence

Şengül

et al. 2014

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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The Taqi Drd2 A1 Allele Is Associated With Alcohol-Dependence Although Its Effect Size Is Small

Abstract: Consequently, the findings in this study lend further support to the notion of an association between the DRD2 A1 allele and alcohol-dependence, although the effect size of the DRD2 A1 allele is small.

Cited by 69 publications

References 14 publications

Reward-Related Genes and Personality Traits in Alcohol-Dependent Individuals: A Pilot Case Control Study

Reward-Related Genes and Personality Traits in Alcohol-Dependent Individuals: A Pilot Case Control Study

Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction

Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A Polymorphisms with Alcohol Dependence

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