The tangled web of dyslipidemia and cancer: Is there any association?

Heshmat-Ghahdarijani, Kiyan; Neshat, Sina; Rezaei, Abbas; Farid, Armita; Sarallah, Rojin; Javanshir, Salar; Ahmadian, Sarina; Chatrnour, Gelayol; Daneii, Padideh

doi:10.4103/jrms.jrms_267_22

Cited by 12 publications

(13 citation statements)

References 52 publications

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“…TG and CHOL are transported via lipoproteins categorized by size, density, and associated apolipoproteins [ 6 ]. The correlation between the prognostic value of serum lipid levels, such as CHOL, TG, HDL, LDL, and cancer is a subject of particular interest, but with limited clinical reporting available in UTUC [ 6 , 17 ]. Apart from the prognostic value of lipid profiles, the association between serum lipid profiles level and urological cancer risk has sparked debate.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma

Tu,

Li,

et al. 2024

World J Oncol

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Background The prognosis of upper tract urothelial carcinoma (UTUC) varies, with T3/T4 UTUC having less than 50% 5-year survival post-radical nephroureterectomy (RNU). Lipid profiles including cholesterol (CHOL), low-density lipoprotein (LDL), and triglycerides (TGs), and high-density lipoprotein (HDL) have shown correlations with oncologic outcomes in various cancers. We aimed to investigate the prognostic significance of the lipid profiles in UTUC patients who had received RNU. Methods In this retrospective study, a total of 217 UTUC patients who underwent RNU were analyzed. Prognostic factors for overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) were assessed using Cox proportional hazards regression model and competing risk analysis. Results The median follow-up duration was 2.36 years. Fifty-one (23.50%) of the patients experienced tumor progression, 16 (7.37%) died from UTUC, and 41 (18.89%) died from all causes during the follow-up period. Multivariate analysis revealed that elevated CHOL, low HDL, and elevated TG were linked to worse OS (P = 0.0188, 0.0002, and 0.0001, respectively). Higher CHOL, LDL, and TG, as well as lower HDL significantly affected PFS (P < 0.001 for all), and elevated CHOL and TG were associated with poorer CSS (P = 0.0033 and 0.0179). A competing risk model indicated that elevated LDL increased the risk of cancer progression (P = 0.407), with CHOL increasing the risk of UTUC-specific mortality (P = 0.0162). Limitations include retrospective design, limited, single-time sampling and relatively small sample size. Conclusions Lipid profiles were identified as prognostic indicators for UTUC patients post-RNU. It highlights the potential importance of lipid management in improving tumor-related outcomes.

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Section: Discussionmentioning

confidence: 99%

Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma

Tu,

Li,

et al. 2024

World J Oncol

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“…Studies show a significantly higher prevalence of metabolic disorders following surgical menopause compared to natural menopause. This association is linked to the sudden decline in estrogen levels caused by surgery, which can lead to endothelial dysfunction, dyslipidemia [1,[26][27][28][29], and increased risk of cardiovascular events [30][31][32][33][34]. Research suggests a 1.5-fold to 9.7-fold increased risk of MetS in women who undergo surgical menopause compared to natural menopause [1,[35][36][37][38][39].…”

Section: Surgical Menopause and Increased Mets Riskmentioning

confidence: 99%

Metabolic Syndrome and Survival Outcomes in Endometrial Cancer

Marin,

Filipescu,

Vladareanu

et al. 2024

Cureus

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Menopause, through attributable estrogen level decline and the corresponding increase in circulating androgens, significantly elevates a woman's risk for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular disease. Metabolic syndrome itself is a cluster of interconnected risk factors, and among them, central obesity is a well-established factor for the development of endometrial cancer (EC), the most common gynecologic malignancy. This research investigates the impact of metabolic syndrome on survival rates among patients with endometrial cancer. The goal is to assess whether having metabolic syndrome or its individual components influences disease-free survival (DFS), overall survival (OS), cancer-specific survival, and recurrence rates. Understanding this link is crucial for determining risk levels and could help tailor treatment approaches for better long-term outcomes in endometrial cancer care.

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“…Clinical and epidemiological studies have linked defects in lipid metabolism to cancer and describe the association of several types of cancers with risk factors for cardiovascular disease [6][7][8]. Moreover, metabolic syndrome, as a cluster of risk factors for ASCVD and type 2 diabetes, has been substantially associated with the onset of malignancies [9].…”

Section: Introductionmentioning

confidence: 99%

Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology, Shared Mechanisms, and Future Management

Katsi

Papakonstantinou

Tsioufis

2023

IJMS

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The involvement of cardiovascular disease in cancer onset and development represents a contemporary interest in basic science. It has been recognized, from the most recent research, that metabolic syndrome-related conditions, ranging from atherosclerosis to diabetes, elicit many pathways regulating lipid metabolism and lipid signaling that are also linked to the same framework of multiple potential mechanisms for inducing cancer. Otherwise, dyslipidemia and endothelial cell dysfunction in atherosclerosis may present common or even interdependent changes, similar to oncogenic molecules elevated in many forms of cancer. However, whether endothelial cell dysfunction in atherosclerotic disease provides signals that promote the pre-clinical onset and proliferation of malignant cells is an issue that requires further understanding, even though more questions are presented with every answer. Here, we highlight the molecular mechanisms that point to a causal link between lipid metabolism and glucose homeostasis in metabolic syndrome-related atherosclerotic disease with the development of cancer. The knowledge of these breakthrough mechanisms may pave the way for the application of new therapeutic targets and for implementing interventions in clinical practice.

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The tangled web of dyslipidemia and cancer: Is there any association?

Cited by 12 publications

References 52 publications

Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma

Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma

Metabolic Syndrome and Survival Outcomes in Endometrial Cancer

Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology, Shared Mechanisms, and Future Management

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