The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer

Song, Qinqin; Zhi, Zhang; Liu, Yingwen; Han, Song; Zhang, Xuemei

doi:10.1016/j.molimm.2014.10.006

Cited by 9 publications

(9 citation statements)

References 45 publications

(37 reference statements)

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“…Our present results supported that the CD55 rs2564978 CC genotype was linked to an increased risk of NSCLC. This finding is similar with our previous result from gastric cancer case-control study [20]. This population data can be explained by our luciferase reporter gene assay.…”

Section: Discussionsupporting

confidence: 93%

A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer

et al. 2016

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CD55, as one of key membrane-bound complement-regulatory proteins (mCRPs), is crucial for the progression of various cancers. This study aims to investigate the role of CD55 variants in the development of non-small cell lung cancer (NSCLC). A case-control study, including 706 lung cancer cases and 706 health controls, was conducted in a Chinese population. The odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression. We found that significantly higher lung cancer risk was linked with CD55 rs2564978 CC genotype (OR = 1.52, 95% CI = 1.11−2.07) or CT genotypes (OR = 1.34, 95% CI = 1.05−1.71), compared to the TT genotype. Stratified analysis showed that rs2564978 CC was associated with NSCLC risk among males (OR = 1.69, 95% CI = 1.14−2.49) and older subjects (OR = 1.75, 95% CI = 1.08−2.82). When stratified by smoking status, the risk effect of rs2564978 CC was more evident among smokers (OR = 2.01, 95% CI = 1.18−3.43) than non-smokers (OR = 1.30, 95% CI = 0.88−1.90). We also conducted the stratified analysis by NSCLC histological types and found that CD55 rs2564978 CC increased the risk of adenocarcinoma with OR (95% CI) of 1.35 (1.01−1.80). The reporter gene expression driven by rs2564978T-containing CD55 promoter was respectively 1.48-fold, 1.96-fold and 1.93-fold higher than those driven by the rs2564978C-containing CD55 promoter in A549, NCI-H2030 and NCI-H23 cells (P = 0.045, 0.010 and < 0.001). These findings indicate that CD55 rs2564978 polymorphism may contribute to an increased risk of NSCLC in Chinese population.

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Section: Discussionsupporting

confidence: 93%

A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer

et al. 2016

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“…Elevated CD55 is correlated with poor prognosis of colorectal, breast, pancreatic, gallbladder (IHCC), and gastric cancers. Paradoxically, CD55 expression is decreased in ovarian cancer and lung cancer, with certain SNPs associated with higher risk such as rs2564978 variant and rs2564978 (36,37,39,45). As for CD59, it was found to be overexpressed in head and neck, colorectal, ovarian, (28,46,47), and in cervical cancer as well (48).…”

Section: Expression Levelmentioning

confidence: 99%

GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets

2020

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With millions of cases diagnosed annually and high economic burden to cover expensive costs, cancer is one of the most difficult diseases to treat due to late diagnosis and severe adverse effects from conventional therapy. This creates an urgent need to find new targets for early diagnosis and therapy. Progress in research revealed the key steps of carcinogenesis. They are called cancer hallmarks. Zooming in, cancer hallmarks are characterized by ligands binding to their cognate receptor and so triggering signaling cascade within cell to make response for stimulus. Accordingly, understanding membrane topology is vital. In this review, we shall discuss one type of transmembrane proteins: Glycosylphosphatidylinositol-Anchored Proteins (GPI-APs), with specific emphasis on those involved in tumor cells by evading immune surveillance and future applications for diagnosis and immune targeted therapy.

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“…Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis and TaqMan SNP genotyping assay were applied for genotyping [11,12]. Genotyping for TLR4 rs1927914 and rs7869402 variants was performed by PCR-RFLP.…”

Section: Genotyping Of the Tlr Variantsmentioning

confidence: 99%

Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility

Gao

et al. 2020

Journal of Oncology

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Toll-like receptors (TLRs) are expressed not only in immune cells but also in a variety of tumor cells. Single-nucleotide polymorphisms (SNPs) located in the TLRs’ promoter or the 3′ untranslated region may affect gene expression by affecting the activity of the promoter or regulating the binding of mRNA to miRNA. This study aimed to investigate the association of the SNPs in TLR genes with the susceptibility to NSCLC. This case-control study involved 700 lung cancer patients and 700 healthy controls. All individuals were genotyped for all selected SNPs in TLR genes using polymerase chain reaction (PCR) test-based restriction fragment length polymorphism (PCR-RFLP) and TaqMan SNP genotyping assay. The association of genetic variations in TLRs with the susceptibility to NSCLC was evaluated by unconditional logistic regression with OR (95% CI). After evaluating transcriptional factor or miRNA binding capability by bioinformatics methods, six TLRs were identified for further analysis. We did not find that TLR3 rs5743303, TLR4 rs1927914, TLR4 rs11536891, TLR5 rs1640816, and TLR7 rs3853839 were associated with NSCLC risk (P>0.05). Our data showed that TLR4 rs7869402 C > T polymorphism reduced the risk of NSCLC with OR (95% CI) of 0.63 (0.45–0.89). When stratified by gender and age, the individuals carrying at least one rs7869402T allele significantly decreased the NSCLC risk among males (OR = 0.58, 95% CI = 0.38–0.87) and among youngsters (OR = 0.43, 95% CI = 0.27–0.69). Smoking stratification analysis showed that the rs7869402T allele-containing genotype reduced the risk of NSCLC with OR (95% CI) of 0.50 (0.29–0.87) among smokers but not among nonsmokers (P>0.05). When the individuals were classed by the pathological type, we found that the rs7869402T-containing genotype was associated with the risk of adenocarcinoma (OR = 0.62, 95% CI = 0.41–0.92) but not with that of squamous cell carcinoma (OR = 0.71, 95% CI = 0.44–1.13) and other types (OR = 0.23, 95% CI = 0.03–1.70). Compared with the TLR4 Ars1927914-Crs7869402-Trs11536891 haplotype, the Grs1927914-Trs7869402-Trs11536891 haplotype was associated with a decreased risk for developing NSCLC with OR (95% CI) of 0.57 (0.41–0.80). These results indicated that the TLR4 rs7869402 variation affects the genetic susceptibility to NSCLC.

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The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer

Cited by 9 publications

References 45 publications

A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer

A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer

GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets

Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility

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