The tachykinin NK-2 receptor antagonist SR48968 does not block noncholinergic contractions in unstable human bladder

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

“…Capsaicin-sensitive afferents may be a part of a spinal, vesico-vesical excitatory (short-loop) reflex providing a neurogenic mechanism for overactive detrusor contractions, both idiopathic and neurogenic (Maggi, 1993). In detrusor tissue from patients with idiopathic detrusor overactivity, blockade of NK receptors did not influence the atropine-resistant response (67%) to nerve stimulation (Moore et al, 2002), thus favoring an effect on the afferent loop of the micturition reflex.…”

“…This does not exclude that atropine resistance may exist in morphologically and/or functionally changed bladders. Thus, the NANC component of the nerve-induced response may be responsible for up to 40 to 50% of the total bladder contraction in different conditions associated with detrusor overactivity Sibley, 1984;Kinder and Mundy, 1985b;Palea et al, 1993a;Bayliss et al, 1999;Moore et al, 2002;O'Reilly et al, 2002).…”

Tachykinins and tachykinin receptors: effects in the genitourinary tract

“…Because of their role during inflammation, it has been speculated that TKs could take part in the non-cholinergic component of the bladder contraction induced by electrical field stimulation, which is magnified in bladders from patients with detrusor instability. However, in detrusor specimens from patients affected by idiopathic detrusor instability, the atropine-resistant (but tetrodotoxin-sensitive) component of electrical field stimulation-induced contraction (that is enhanced in these patients) was not affected by the NK 2 receptor antagonist SR48968 (Moore et al, 2002), thus excluding the possibility that TKs enhance the efferent parasympathetic outflow in pathological conditions. However, it is worth noting that the modulation of electrical field stimulation-induced detrusor contractility by TK receptor antagonists can be appreciated only when stimulation parameters are set to recruit TRPV1 expressing sensory nerves.…”

Les troubles vésicosphinctériens après accident vasculaire cérébral en 2008

“…Il existe par ailleurs des voies de recherche, actuellement, sur des cibles thérapeutiques nouvelles, telles que les tachykinines [32].…”