The curation design of cultural heritage sites, such as museums, influence the level of visitor satisfaction and the possibility of revisitation; therefore, an efficient exhibit layout is critical. The difficulty of determining the behavior of visitors and the layout of galleries means that exhibition layout is a knowledge-intensive, time-consuming process. The progressive development of machine learning provides a low-cost and highly flexible workflow in the management of museums, compared to traditional curation design. For example, the facility’s optimal layout, floor, and furniture arrangement can be obtained through the repeated adjustment of artificial intelligence algorithms within a relatively short time. In particular, an optimal planning method is indispensable for the immense and heavy trains in the railway museum. In this study, we created an innovative strategy to integrate the domain knowledge of exhibit displaying, spatial planning, and machine learning to establish a customized recommendation scheme. Guided by an interactive experience model and the morphology of point–line–plane–stereo, we obtained three aspects (visitors, objects, and space), 12 dimensions (orientation, visiting time, visual distance, centrality, main path, district, capacity, etc.), 30 physical principles, 24 suggestions, and five main procedures to implement layout patterns and templates to create an exhibit layout guide for the National Railway Museum of Taiwan, which is currently being transferred from the railway workshop for the sake of preserving the rail culture heritage. Our results are suitable and extendible to different museums by adjusting the criteria used to establish a new recommendation scheme.