The T29C (rs1800470) polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with restenosis after coronary stenting in Mexican patients

Fragoso, José Manuel; Zúñiga, Joaquı́n; Arellano-González, Marva; Álvarez-León, Edith; Villegas-Torres, Beatriz; Cruz‐Lagunas, Alfredo; Delgadillo-Rodríguez, Hilda; Peña‐Duque, Marco Antonio; Martínez-Ríos, Marco Antonio; Vargas‐Alarcón, Gilberto

doi:10.1016/j.yexmp.2014.11.007

Cited by 18 publications

(16 citation statements)

References 38 publications

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“…Имеющиеся в литературе результаты исследований, посвященных данному вопросу, свидетельствуют об имеющейся ассоциации полиморфизмов rs1800470 гена TGF-β1 с различной патологией сосудистого бассейна сердца. Так, в работе Fragoso JM, et al (2015) Рис. 3 (А, Б).…”

Section: Discussionunclassified

“…Динамика рестеноза стента у носителей генотипов rs1800470 гена TGF-β1: А -аллель А/GG; Б -аллель G/АА. в Мексике была продемонстрирована ассоциация аллеля риска А rs1800470 гена TGF-В1 с развитием рестеноза стента у 244 больных ОКС (ОШ=2,06 (95% ДИ: 1,03-4), р=0,030) [12]. В европейской популяции было проведено подобное исследование Osadnik T, et al (2016) у 265 больных стабильной ИБС, перенесших имплантацию металлического стента.…”

Section: Discussionunclassified

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Angiographic dynamics of coronary flow state after percutaneous coronary intervention in carriers of polymorphic RS1800470 variants of the TGF-β1 gene

2019

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Aim. To study the relationship between the angiographic dynamics of the state of the coronary bed in patients undergoing percutaneous coronary intervention (PCI) due to myocardial infarction (MI) and the carriage of polymorphic rs1800470 variants of the transforming growth factor beta-1 gene (TGF-β1).Material and methods. The study included 89 men with MI of the Caucasian race aged 32 to 65 years (52 [45,0-58,0]). Genomic deoxyribonucleic acid (DNA) was extracted from venous blood by phenol-chloroform technique. The rs1800470 polymorphism of the TGF-β1 gene was tested using real-time polymerase chain reaction (PCR) (TaqMan probes, AB 7900HT). Assessment of the severity of coronary lesions was carried out initially according to the standard coronary angiography (CAG) protocol with the calculation of the Gensini score. CAG was also conducted in the dynamics after 5-103 months (42,3±29,5 months) of the study beginning.Results. In male carriers of the rs1800470 A allele of the TGF-β1 gene, the mean values of the Gensini score statistically significantly increased (47,5±34,1 (CAG-1) and 64,5±35,5 (CAG-2), p <0,001) in comparison with carriers of the homozygous GG rs1800470 variant of the TGF-β1 gene (43,5±21,1 (CAG-1) and 46,2±23,2 (CAG2), p=0,066). In patients who had rs1800470 A allele of the TGF-β1 gene, a 20%decrease in the Gensini score was observed after 7 months (p=0,013), and 30% — after 5 months (p=0,003) of the initial CAG. The development of late stent restenoses in carriers of the rs1800470 A allele and the homozygous risk genotype AA of the TGF-β1 gene was noted at an earlier date — 8 (p=0,047) and 12 months (p=0,002), respectively.Conclusion. Currently, the conduct of CAG in dynamics in patients undergoing PCI is recommended as clinically indicated. The exception is the group of patients who underwent endoprosthesis replacement of the left coronary artery or have uncorrected stenosis of a different location from 3 to 12 months after PCI. The presented data show a possible predictor role of rG1800470 polymorphism of the TGF-β1 gene in relation to the progression of coronary atherosclerosis and the development of late stent restenoses.

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Section: Discussionunclassified

Angiographic dynamics of coronary flow state after percutaneous coronary intervention in carriers of polymorphic RS1800470 variants of the TGF-β1 gene

2019

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“…Current studies have examined the relationship between TGF-β1 polymorphisms and ISR. [32][33][34] However, none of the TGF-β1 genetic variations has ever been studied in relation to the risk of ISR after BMS implantation in the Chinese Han population. In the present study, we observed that Cdominant CC/CT genotype frequency of TGF-β1 869T/C polymorphism T869C (rs1800470; Leu10/Pro10; T29C, codon10) is significantly higher in the ISR group after coronary implantation of BMS among Chinese Han patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are limited data assessing the impact of these variants on ISR. [32][33][34] Additionally, whether the genetic variations in TGF-β1 are associated with the risk of ISR after coronary implantation of bare metal stent (BMS) among Chinese Han patients has not been studied.…”

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confidence: 99%

Role of Gene Polymorphisms/Haplotypes and Plasma Level of TGF-β1 in Susceptibility to In-Stent Restenosis Following Coronary Implantation of Bare Metal Stent in Chinese Han Patients

Chen

Zhang

et al. 2018

Int. Heart J.

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SummaryTransforming growth factor (TGF)-β1 has been implicated in the pathogenesis of restenosis. However, the role of TGF-β1 polymorphisms in development of in-stent restenosis (ISR) after coronary bare metal stent (BMS) implantation in Chinese Han population has not been reported to date. The aim of this study was to explore the association between TGF-β1 gene polymorphisms (-509C/T and 869T/C) and its plasma level in Chinese Han patients with BMS-ISR.We investigated 419 patients after successful coronary stent placement. All patients were reexamined by angiography. Genotyping for the two TGF-β1 gene polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Plasma TGF-β1 levels were measured by enzymelinked immunosorbent assay.Ninety-two patients (21.96%) developed ISR during the follow-up period. The multivariable analysis adjusted for potential confounders and it revealed that the C allele of TGF-β1 869T/C polymorphism was linked to an increased risk of ISR in both additive (Per each C allele) and dominant (TC+CC versus TT) models with odds ratios (ORs) of 1.88 (95% confidence interval [CI]: 1.21-2.84, P = 0.008) and 2.52 (95% CI: 1.40-4.80, P = 0.005), respectively. In accord with this, C-dominant CC/CT genotype was linked to higher plasma TGF-β1 level compared to TT genotype. One haplotype (TC) (-509T, +869C) was associated with an increased risk for ISR (OR = 1.48, 95% CI: 1.06-2.06, P = 0.010).The C allele of TGF-β1 869T/C polymorphism, correlated with high plasma TGF-β1 level, represented an independent risk factor for BMS-ISR in Chinese Han patients with coronary artery disease.(Int Heart J 2018; 59: 161-169)

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“…Так, при исследованиях, проводимых среди лиц ази-атской популяции, было установлено, что полимор-физмы 174G/C, С572G, ОНП rs8034928 и rs11556218 гена IL-6 статистически значимо связаны с повы-шенным риском ИБС [5][6][7][8]. Учеными из Мексики во главе с Fragoso JM, et al в 2015г выявлена ассоци-ация полиморфизмов rs1800796 и rs2069827 гена IL-6 с развитием рестенозов коронарных артерий у мекси-канских пациентов [9]. В отношении европейской популяции было доказано, что гомозиготный гено-тип Т/Т полиморфизма С(-260)T гена IL-6 выде-лялся чаще при первом клиническом проявлении коронарной болезни сердца [10].…”

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The Role of Interleukin-6 Gene in Development of Idiopathic Sick Sinus Syndrome

Никулина¹,

Marilovtseva²,

Чернова³

et al. 2016

Russ J Cardiol

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Цель. Изучить ассоциацию полиморфизма rs1800795 гена IL-6 с развитием идиопатического синдрома слабости синусового узла (СССУ). Материал и методы. Проведено обследование 109 больных с идиопатиче-ским СССУ и 59 их здоровых родственников I, II, III степени родства, а также 173 пациента контрольной группы. Пациенты основной группы разделены на подгруппы соответственно полу и клиническому варианту течения заболе-вания. Всем пациентам проведено стандартное клинико-инструментальное кардиологическое обследование и молекулярно-генетическое исследование ДНК. Статистическую обработку данных проводили с использованием пакета программ "Statistica 7.0". Результаты. Установлено статистически значимое преобладание гомозигот-ного генотипа по редкому аллелю исследуемого гена в группе контроля (18,5%±3,0) по сравнению с пациентами с идиопатическим СССУ (8,5%±3,1), p=0,039, а также по сравнению с подгруппой мужчин с СССУ (5,2%±8 среди мужчин с СССУ против 30,8%±9,1 в группе контроля, р=0,03). Кроме того, установлено статистически значимое преобладание распространенного гено-типа гена IL-6 среди мужчин с компенсированным вариантом СССУ (69,2%±12,8) по сравнению с контрольной группой (23,1%±8,3, р=0,005). Заключение. Вероятно, гомозиготный генотип GG гена IL-6 играет протек-тивную роль в отношении развития идиопатического СССУ.

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The T29C (rs1800470) polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with restenosis after coronary stenting in Mexican patients

Cited by 18 publications

References 38 publications

Angiographic dynamics of coronary flow state after percutaneous coronary intervention in carriers of polymorphic RS1800470 variants of the TGF-β1 gene

Angiographic dynamics of coronary flow state after percutaneous coronary intervention in carriers of polymorphic RS1800470 variants of the TGF-β1 gene

Role of Gene Polymorphisms/Haplotypes and Plasma Level of TGF-β1 in Susceptibility to In-Stent Restenosis Following Coronary Implantation of Bare Metal Stent in Chinese Han Patients

The Role of Interleukin-6 Gene in Development of Idiopathic Sick Sinus Syndrome

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