The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia

Bondy, Brigitta; Spaeth, M. J. Drake; Offenbäecher, Martin; Glatzeder, K.; Stratz, T; Schwarz, Markus J.; Jonge, Sylvia de; Krüger, Marc; Engel, Rolf R.; Färber, L; Pongratz, D.; Ackenheil, Manfred

doi:10.1006/nbdi.1999.0262

Cited by 176 publications

(102 citation statements)

References 28 publications

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“…It is defi ned by a T-C transition at position 102. This mutation does not alter the amino acid composition and has therefore no infl uence on the receptor protein [10] . The -1438G/A polymorphism, a novel G-A base change at position -1438 of the promoter region, has been detected, which is in very strong linkage disequilibrium with the T102C polymorphism of 5-HT 2A [11] .…”

Section: Introductionmentioning

confidence: 99%

Association of the –1438G/A Polymorphism of the 5-HT<sub>2A </sub>Receptor Gene with Obstructive Sleep Apnea Syndrome

Bayazıt

Yılmaz

Çiftçi

et al. 2006

ORL

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Objective: Serotonergic neurons innervating motoneurons increase their firing rates in response to respiratory challenges, and long-term facilitation of respiratory activity in response to hypoxia is serotonin (5-HT) dependent. Polymorphism of the genes which code for 5-HT receptors may affect functions of the serotonergic system, and may be associated with obstructive sleep apnea syndrome (OSAS). The objective in this study was to assess the significance of T102C and –1438G/A polymorphisms of the 5-HT_2A receptor gene in OSAS. Methods: Fifty-five patients with OSAS and 102 healthy volun teers were included for genetic analyses of T102C and –1438G/A polymorphisms of the 5-HT_2A receptor gene. Results: For the T102C polymorphism, there was no significant difference between the patients and controls and both genders (p > 0.05). For the –1438G/A polymorphism, the A/A and G/A genotypes were overrepresented in the patients and controls, respectively (p = 0.045). In the control group, the genotypes of both genders were not significantly different (p > 0.05). In the patients, the A/A and G/A genotypes were overrepresented in males and females, respectively (p = 0.035). Concerning males, the A/A genotype was overrepresented in patients (p = 0.007). Conclusion: Serotonergic mechanisms appear to be related to OSAS. The T102C polymorphism of the 5-HT_2A receptor gene is not associated with OSAS. However, the –1438G/A polymorphism is associated with OSAS occurrence, especially in male patients. This polymorphism may also be associated with different OSAS incidences of both genders.

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Section: Introductionmentioning

confidence: 99%

Association of the –1438G/A Polymorphism of the 5-HT<sub>2A </sub>Receptor Gene with Obstructive Sleep Apnea Syndrome

Bayazıt

Yılmaz

Çiftçi

et al. 2006

ORL

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“…Bondy et al [14] proposed that T102C polymorphism of the 5-HT2A receptor gene is associated with nociception, and that the fibromyalgia patients with T/T genotype had a lower pain threshold. According to Gursoy et al [15], the fibromyalgia patients with T/T genotype had more psychiatric symptoms as determined with SCL-90 symptom checklist scores.…”

Section: Discussionmentioning

confidence: 99%

T102C Polymorphisms at the 5-HT2A Receptor Gene in Turkish Schizophrenia Patients: A Possible Association with Prognosis

Herken

Erdal

Aynacioglu³

2003

Neuropsychobiology

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Background: Serotonergic system abnormalities have been implicated in the pathogenesis of schizophrenia. The 5-HT2A receptor gene polymorphism has long been implicated to play a role in the pathogenesis of schizophrenia. Aim: In this study, we assessed the relationship of schizophrenia and its subgroups with 5-HT2A receptor gene polymorphism, and attempted to evaluate a possible correlation between the severity and prognosis of the illness and 5-HT2A receptor gene polymorphism. Method: Our study comprised 141 unrelated subjects who strictly met DSM-IV criteria for schizophrenia, and 79 healthy unrelated controls, all of Turkish origin. A clinical evaluation of all patients was accomplished applying the Brief Psychiatric Rating Scale (BPRS) test. The analysis of 5-HT2A receptor gene polymorphism was performed using the polymerase chain reaction technique. Results: Regarding 5-HT2A receptor gene polymorphisms, no statistically significant difference was found between schizophrenic patients and control subjects (p > 0.05). There was no significant difference between the average of BPRS points of the patients and 5-HT2A receptor gene polymorphisms (p > 0.05). Although there was no correlation between the duration of illness and polymorphism (p > 0.05), the frequency of hospitalization was found to be higher in the patients with T/C and T/T genotypes compared with the patients with C/C genotype (p < 0.05). Conclusion: Our findings indicate that the T102C polymorphisms of the 5-HT2A receptor gene does not play a substantial role in schizophrenia nor help evaluate susceptibility to schizophrenia. Since the 5-HT2A receptor gene polymorphism is associated with the frequency of hospitalization of the patients, it may be an indicator of prognosis in schizophrenia or help differentiate the patients who are somewhat refractory to antipsychotic treatment.

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“…In another study, these researches reported on a significantly different genotype distribution in FMS patients with a decrease in T/T and an increase in both T/C and C/C genotypes compared to the control population (30). Cohen and colleagues (31) performed genotyping in a group of 99 female FMS patients from two Israeli ethnic groups.…”

Section: Geneticsmentioning

confidence: 99%