The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy

Dinshaw, Leon; Münch, Julia; Dickow, Jannis; Lezius, Susanne; Willems, Stephan; Hoffmann, Boris; Patten, Monica

doi:10.1007/s00392-017-1164-4

Cited by 15 publications

(8 citation statements)

References 31 publications

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“…As a result, CKD and RRT can cause electrical abnormalities in the heart, frequently leading to fatal arrhythmia. In addition, increased blood pressure and volume load in CKD patients may also contribute to a background of mechanical and electrical imbalances in myocytes, thereby increasing the likelihood of ventricular tachycardia [ 22 , 23 , 24 ]. Therefore, CKD patients may have a higher probability of cardiac arrest than non-CKD patients because of the high risk of fatal arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Effect of Underlying Chronic Kidney Disease and Renal Replacement Therapy on the Outcome of Patients after Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study

et al. 2022

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Background and Objectives: This study assessed the prognostic value of underlying chronic kidney disease (CKD) and renal replacement therapy (RRT) on the clinical outcomes from out-of-hospital cardiac arrest (OHCA). Materials and Methods: This retrospective study was conducted utilizing the population-based OHCA data of South Korea between 2008 and 2018. Adult (>18 years) OHCA patients with a medical cause of cardiac arrest were included and classified into three categories based on the underlying CKD and RRT: (1) non-CKD group; (2) CKD without RRT group; and (3) CKD with RRT group. A total of 13,682 eligible patients were included (non-CKD, 9863; CKD without RRT, 1778; CKD with RRT, 2041). From the three comparison subgroups, data with propensity score matching were extracted. The influence of CKD and RRT on patient outcomes was assessed using propensity score matching and multivariate logistic regression analyses. The primary outcome was survival at hospital discharge and the secondary outcome was a good neurological outcome at hospital discharge. Results: The two CKD groups (CKD without RRT and CKD with RRT) showed no significant difference in survival at hospital discharge compared with the non-CKD group (CKD without RRT vs. non-CKD, p > 0.05; CKD with RRT vs. non-CKD, p > 0.05). The non-CKD group had a higher chance of having good neurological outcomes than the CKD groups (non-CKD vs. CKD without RRT, p < 0.05; non-CKD vs. CKD with RRT, p < 0.05) whereas there was no significant difference between the two CKD groups (CKD without RRT vs. CKD with RRT, p > 0.05). Conclusions: Compared with patients without CKD, the underlying cause of CKD—regardless of RRT—may be linked to poor neurological outcomes. Underlying CKD and RRT had no effect on the survival at hospital discharge.

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Section: Discussionmentioning

confidence: 99%

Prognostic Effect of Underlying Chronic Kidney Disease and Renal Replacement Therapy on the Outcome of Patients after Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study

et al. 2022

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“…T-peak to T-end interval is depicted as an index for transmural dispersion of ventricular repolarization. Any prolongation in this interval has been considered as a risk factor for ventricular tachyarrhythmia (Dinshaw et al, 2018;Tse et al, 2018). A Turkish study determined that heart rate was significantly higher and maximum P wave duration and P wave dispersion were significantly longer in patients with iron deficiency anemia when compared to healthy controls (Simsek et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

How Are Cardiac Functions Altered in Pediatric Patients Receiving Oral Iron Supplementation Due to Anemia?

et al. 2021

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Migraine is a multifactorial neurovascular syndrome characterized by typical headache attacks that occur with internal and external triggering factors in individuals with genetic susceptibility. It affects more than 12% of the general population. The aim of the present study is to compare the morphometric measurements of the determined white matter structures with the control group to investigate whether there is a structural difference in white matter structures in female patients with migraine. The width of the internal capsule parts (anterior limb, posterior limb and genu) and genu angle was evaluated through MRI. Corpus callosum related measurements were determined in the sagittal section. It was manually traced following its edge on the midsagittal slice of T1 images, where its structure appeared most remarkable. The right and left internal capsule related measurements were compared with migraine and control groups. Except the genu angle, there were statistically significant difference between all measurements and widths in the migraine group were greater than controls. No significant difference was found between the corpus callosum related measurements in the comparison of both groups. Internal capsule consists of several essential white matter fiber bundles of the brain, and is strongly connected between a range of cortical and subcortical anatomical structures. It has a crucial importance for brain functions and it can be affected by a variety of pathologies. The corpus callosum is the main fiber tract connecting two hemispheres with extensive connections and is topographically organized. It has been investigated in several neurodegenerative diseases as a marker for cortical pathology. Knowing the white matter structure in migraine patients, determining its prevalence, and its correlation with the severity, type and duration of migraine can give an idea to clinicians.

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“…Hence, in patients with leprosy, in addition toQT and QTc prolongation, LAH that occurs at high rates is also an important ECG finding that should be considered, and it is highly important to monitor the QT and QTc intervals on ECG to predict arrhythmic events in these patients. On the other hand, recent studies showed that prolongation of the Tp-e interval is a marker of ventricular arrhythmias, increased risk of mortality in congenital long QT syndromes, hypertrophic cardiomyopathy, and also in patients with myocardial infarction who underwent primary percutaneous coronary intervention (18)(19)(20)(21). Prolongation of the Tp-e interval indicates a period of potential vulnerability to reentrant ventricular arrhythmias (22).…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Findings of Leprosy

Yıldırım¹,

Seçen²,

Demir³

et al. 2018

Erciyes Med J

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Objective: The purpose of the present study was to investigate the effect of leprosy on basic electrocardiography (ECG) parameters. Materials and Methods: A total of 66 patients including 33 patients with leprosy (mean age: 70.06 years, 24 males) and 33 control patients (mean age: 56.66 years, 15 males) were included in the study. ECG recordings of all patients were obtained, and groups were compared in terms of heart rate, PR, QT, QTc, JTc, and T peak to T end (Tp-e) durations and branch blocks. Results: QT (391.30 vs. 367.66, p<0.01), QTc (423.57 vs. 407.15, p<0.01), and Tp-e (74.18 vs. 66.93, p<0.001) intervals were significantly prolonged in the leprosy group. The left anterior hemiblock (LAH) was observed more in patients with leprosy (42.4% in 14 patients) than in the non-leprosy group (42.4% vs. 12.1%, p<0.01). In addition, the rate of the unifascicularblock was significantly higher in the leprosy group (39.4% vs. 9.1%, p<0.01). Conclusion: Leprosy has a significant effect on QT, QTc, and Tp-e intervals. Prolongation of the QT, QTc, and Tp-e intervals is an indicator of leprosy's effect on the cardiac autonomic system. The ratio of the LAH is also rather high, and that may be a marker of the area where leprosy is most effective on the heart.

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The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy

Abstract: A prolonged TpTe is associated with VA and AT in HCM. Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification.

Cited by 15 publications

References 31 publications

Prognostic Effect of Underlying Chronic Kidney Disease and Renal Replacement Therapy on the Outcome of Patients after Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study

Prognostic Effect of Underlying Chronic Kidney Disease and Renal Replacement Therapy on the Outcome of Patients after Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study

How Are Cardiac Functions Altered in Pediatric Patients Receiving Oral Iron Supplementation Due to Anemia?

Electrocardiographic Findings of Leprosy

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