The T-cell repertoire is not dictated by self antigens alone

Zhang, L.; Rood, Jon J. van; Claas, Frans H.J.

doi:10.1016/0923-2494(91)90044-j

Cited by 15 publications

(10 citation statements)

References 27 publications

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“…31 This observation was apparently in keeping with data published by some authors on a blunted immune response to maternal cells or soluble HLA antigens, 30,33,34 but in contrast with results reported by others, 32,35 who did not show any difference in the CTLp frequency towards NIMA and NIPA. Results of the present study indicate that absence of response in 'bulk culture' does not seem to be due to deletion of NIMA-reactive cytotoxic cells, but it can rather be attributed to the action of regulatory populations, displaying their effect in 'bulk culture' and unable to carry out their function in a limiting dilution condition.…”

Section: Discussioncontrasting

confidence: 53%

“…29 However, these favourable clinical effects of NIMA have not found a biological explanation, since conflicting results on development of NIMA-specific CTL have been published. [30][31][32][33][34][35] We previously observed that CBMC from about 50% of neonates are unable to develop CTL activity when challenged in vitro with allogeneic cells in 'bulk culture' conditions. In the great majority of remaining individuals who were able to mount a cytotoxic response against paternal cells, CBMC were unable to kill cells of maternal origin.…”

mentioning

confidence: 99%

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Characterisation of CTL directed towards non-inherited maternal alloantigens in human cord blood

Moretta

Locatelli

Mingrat

et al. 1999

Bone Marrow Transplant

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Summary:Allogeneic cord blood transplantation (CBT), especially from unrelated donors, is being increasingly used for treating paediatric patients with both malignant and nonmalignant disorders. Recent clinical and experimental evidence suggests that human cord blood mononuclear cells (CBMC) may acquire in utero a state of tolerance towards non-inherited maternal antigens (NIMA). In order to better define this phenomenon, we measured, by means of a limiting dilution assay (LDA), the frequency of NIMA-specific CTL precursors ( Over the past decade, allogeneic cord blood transplantation (CBT) from both related and unrelated donors has been used increasingly for the treatment of paediatric patients with both malignant and non-malignant disorders. 1-4 Previously published results demonstrate that, at least when the donor is a compatible relative, CBT recipients experience a

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Section: Discussioncontrasting

confidence: 53%

mentioning

confidence: 99%

Characterisation of CTL directed towards non-inherited maternal alloantigens in human cord blood

Moretta

Locatelli

Mingrat

et al. 1999

Bone Marrow Transplant

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“…However, we favour the hypothesis that these non-inherited maternal HLA antigens themselves are transmitted to the fetus and exert their effect through the shaping of the T cell repertoire of the child in utero 15. The observation that 50% of the patients that receive multiple blood transfusions do not form antibodies against the non-inherited maternal HLA antigens supports this hypothesis 16.…”

Section: Discussionmentioning

confidence: 52%

Influence of non-inherited maternal HLA-DR antigens on susceptibility to rheumatoid arthritis

Horst‐Bruinsma

Hazes²,

Schreuder³

et al. 1998

Annals of the Rheumatic Diseases

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Objective-It has recently been observed that non-inherited maternal DR4 antigens (NIMAs) of DR4 negative rheumatoid arthritis (RA) patients were increased compared with non-inherited paternal DR4 antigens (NIPAs). The aim of this study was to determine the prevalence of non-inherited DR4 antigens and DRB1 alleles in parents of RA patients. Methods-HLA-DR serology and DRB1 typing was performed in 97 RA patients and their parents. NIMA and NIPA frequencies were compared, stratified according to the presence of DR4 and/or the shared epitope (SE). Results-In

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“…It was then proposed that NIMA exposure might be one such environmental factor. [50] However, in that study, neither the mechanism of such phenomenon nor its association with MMc was addressed.…”

Section: Transplacental Cell Trafficmentioning

confidence: 99%

“…They found that as much as 50% of those patients did not develop antibodies against NIMA; no such protection was afforded to the NIPA in the same cohort of highly sensitized individuals. [49] Another important work was an observational study by Zhang et al in 1991. In that study, wherein the frequency of CTLs was analyzed, it was found that not only self-HLA antigens determine the CTL repertoire. In that study, up to 50% of homozygous twin pairs showed disparity of CTL allorepertoire, suggesting that environmental factors influence T cell selection and regulation.…”

Section: Transplacental Cell Trafficmentioning

confidence: 99%