The systolic–diastolic difference in carotid stiffness is increased in type 2 diabetes

Veugen, Marja G.J.; Henry, Ronald M.A.; Sloten, Thomas T. van; Hermeling, Evelien; Rocca, Hans‐Peter Brunner‐La; Schram, Miranda T.; Dagnelie, Pieter C.; Schalkwijk, Casper G.; Kroon, Abraham A.; Stehouwer, Coen D. A.; Reesink, Koen D.

doi:10.1097/hjh.0000000000001298

Cited by 7 publications

(9 citation statements)

References 57 publications

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“…The mBRS shows the local carotid pulse wave velocity in meters per second (m/s). It is a widely accepted and used marker of local arterial stiffness 11,12,20 . Other elastic parameters of the carotid artery that represent other metrics of the mechanical component of BRS were also calculated (Supplemental material).…”

Section: Definition Of Groupsmentioning

confidence: 99%

“…Thirdly, analyses were repeated using compliance coefficient, distensibility coefficient and Young's elastic modulus representing other metrics of the mechanical component of BRS. Last, to ease international comparison with other studies, analyses were only adjusted for age, sex and mean BP 9,11 . In all analyses, the continuous variables were included in the final models in standardized forms using z-scores.…”

Section: Definition Of Groupsmentioning

confidence: 99%

“…Furthermore, the age-related decline in global BRS is attributable to arterial stiffening and damaged neural control of the baroreflex 7,8 . However, whether the previously observed impairment in global BRS in patients with T2D is due to altered mBRS or nBRS (or both) is not well understood: data regarding mBRS parameters are controversial [9][10][11] and alterations in the nBRS have not yet been directly examined. Furthermore, prediabetic states such as metabolic syndrome (MetS) or impaired fasting glucose (IFG) may differentially influence the two components 10,12,13 .…”

Section: Graphic Abstract Introductionmentioning

confidence: 99%

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Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity

Cseh

Climie

Offredo

et al. 2020

ATVB

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Objective. Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural and/or mechanical component of the BRS (nBRS and mBRS, respectively) is altered in those with high metabolic risk (HMR, impaired fasting glucose and/or metabolic syndrome) or with overt T2D, is unknown. We examined this in a community-based observational study, the Paris Prospective Study III. Approach and Results. In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low frequency gain, from carotid distension rate and RR intervals) and mBRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared to subjects with normal glucose metabolism (NGM) and nBRS or mBRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (61±6 years, 77% male), 1450 subjects with HMR (60±6 years, 72% male) and 5857 subjects with NGM (59±6 years, 57% male). Compared to NGM, nBRS was significantly lower in HMR subjects (β=-0.07, 95% CI-0.12,-0.01, p=0.029), and in subjects with T2D (β=-0.18, 95% CI-0.29,-0.07, p=0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mBRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome. Conclusion. In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared to NGM subjects.

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Section: Definition Of Groupsmentioning

confidence: 99%

Section: Definition Of Groupsmentioning

confidence: 99%

Section: Graphic Abstract Introductionmentioning

confidence: 99%

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Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity

Cseh

Climie

Offredo

et al. 2020

ATVB

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“…Khamdaeng et al (64) considered the difference in stiffness at diastolic and systolic pressure and used a twodimensional, nonlinear, hyperelastic model to infer differences in elastin and collagen elastic moduli from pressure-area data, as obtained in young healthy volunteers. This approach was pioneered by our laboratory at carotid level (47,48,147) and recently extended to the proximal aorta (56). In their elegant study, Gaddum et al (42) actively modified transmural pressure over a considerable range (by Valsalva and Mueller maneuvers in patients with hypertension and matched controls) to quantify the pressure dependence of PWV (measured over the arch-diaphragm trajectory by Doppler transit time).…”

Section: Content Analysis Of Selected Papersmentioning

confidence: 99%

“…The functional measure obtained from the physical measurement is either a regionally determined pulse wave velocity (PWV; in m/s) or a locally determined distensibility coefficient (DC; in 1/MPa), the latter of which decreases with increasing stiffness (16). From these primary measurements and concepts, measures are derived to 1) harmonize units and interpretation (e.g., a PWV can be derived from a DC to interpret absolute values and changes) (16,147) and/or 2) correct for the (confounding) influence of actual blood pressure on the arterial stiffness observed (117,126).…”

Section: Introductionmentioning

confidence: 99%

Constitutive interpretation of arterial stiffness in clinical studies: a methodological review

Reesink

Spronck

2019

American Journal of Physiology-Heart and Circulatory Physiology

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Clinical assessment of arterial stiffness relies on noninvasive measurements of regional pulse wave velocity or local distensibility. However, arterial stiffness measures do not discriminate underlying changes in arterial wall constituent properties (e.g., in collagen, elastin, or smooth muscle), which is highly relevant for development and monitoring of treatment. In arterial stiffness in recent clinical-epidemiological studies, we systematically review clinical-epidemiological studies (2012–) that interpreted arterial stiffness changes in terms of changes in arterial wall constituent properties (63 studies included of 514 studies found). Most studies that did so were association studies (52 of 63 studies) providing limited causal evidence. Intervention studies (11 of 63 studies) addressed changes in arterial stiffness through the modulation of extracellular matrix integrity (5 of 11 studies) or smooth muscle tone (6 of 11 studies). A handful of studies (3 of 63 studies) used mathematical modeling to discriminate between extracellular matrix components. Overall, there exists a notable gap in the mechanistic interpretation of stiffness findings. In constitutive model-based interpretation, we first introduce constitutive-based modeling and use it to illustrate the relationship between constituent properties and stiffness measurements (“forward” approach). We then review all literature on modeling approaches for the constitutive interpretation of clinical arterial stiffness data (“inverse” approach), which are aimed at estimation of constitutive properties from arterial stiffness measurements to benefit treatment development and monitoring. Importantly, any modeling approach requires a tradeoff between model complexity and measurable data. Therefore, the feasibility of changing in vivo the biaxial mechanics and/or vascular smooth muscle tone should be explored. The effectiveness of modeling approaches should be confirmed using uncertainty quantification and sensitivity analysis. Taken together, constitutive modeling can significantly improve clinical interpretation of arterial stiffness findings.

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a. European Research Centres

2024

Early Vascular Aging (EVA)

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The systolic–diastolic difference in carotid stiffness is increased in type 2 diabetes

Cited by 7 publications

References 57 publications

Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity

Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity

Constitutive interpretation of arterial stiffness in clinical studies: a methodological review

a. European Research Centres

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