The systems containing clays and clay minerals from modified drug release: A review

Rodrigues, Luís Alberto de Sousa; Figueiras, Ana; Veiga, Francisco; Freitas, Rivelilson Mendes de; Nunes, Lívio César Cunha; Filho, Edson Cavalcanti da Silva; Leite, Cleide Maria da Silva

doi:10.1016/j.colsurfb.2012.10.068

Cited by 186 publications

(84 citation statements)

References 113 publications

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“…2 Nanoclays also have highly desirable dietary, bacterial and metabolic detoxification characteristics 15 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Limitations such as poor patient compliance (due to missing or altering dosages) and difficulty in attainment of steady state conditions (as a result of peakvalley plasma concentration fluctuations) have led to poor drug efficacy and toxicity as consequences of underdosing and overdosing of drugs respectively in patients. 2 Drug delivery systems have been designed to overcome these limitations and extend, delay and target drug release [3][4][5][6] . When properly designed, controlled drug delivery systems should be able to deliver drugs at a predetermined rate and manner, either locally or systemically, for a specific period of time after drug administration, which can eliminate excessive fluctuations of drug plasma concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Ekanem

Nabavi

Vladisavljević

et al. 2015

ACS Appl. Mater. Interfaces

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Biodegradable poly(DL-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable size, shape, internal structure and surface morphology were produced by counter-current flow focusing in axisymmetric (3D) glass capillary devices. The dispersed phase was composed of 0.5-2 wt% polymer solution in a volatile 2 organic solvent (ethyl acetate or dichloromethane) and the continuous phase was 5 wt% aqueous poly(vinyl alcohol) solution. The droplets with a coefficient of variation in dripping regime below 2.5 % were evaporated to form polymeric particles with uniform sizes ranging between 4-30 µm. The particle microstructure and surface roughness were modified by adding nanofiller (montmorillonite nanoclay) or porogen (2-methylpentane) in the dispersed phase to form less porous polymer matrix or porous particles with golf-ball-like dimpled surface, respectively. The presence of 2-4 wt% nanoclay in the host polymer significantly reduced the release rate of paracetamol and prevented the early burst release, as a result of reduced polymer porosity and tortuous path for the diffusing drug molecules. Numerical modelling results using the volume of fluid-continuum surface force model agreed well with experimental behaviour and revealed trapping of nanoclay particles in the dispersed phase upstream of the orifice at low dispersed phase flow rates and for 4 wt% nanoclay content, due to vortex formation. Janus PLA/PCL (polycaprolactone) particles were produced by solvent evaporation-induced phase separation within organic phase droplets containing 3 % (v/v) PLA/PCL (30/70 or 70/30) mixture in dichloromethane. A strong preferential adsorption of Rhodamine 6G dye onto PLA was utilized to identify PLA portions of the Janus particles by Confocal Laser Scanning Microscopy (CLSM). Uniform hemispherical PCL particles were produced by dissolution of PLA domes with acetone.

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“…2 Nanoclays also have highly desirable dietary, bacterial and metabolic detoxification characteristics 15 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Ekanem

Nabavi

Vladisavljević

et al. 2015

ACS Appl. Mater. Interfaces

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“…Desvantagens estas que incluem a possível toxicidade, a liberação prematura e exagerada, a exigência de procedimentos invasivos quando usados em implantes ou ainda à remoção do material utilizado e que eleva os custos de produção, além da falta de correlação entre os ensaios in vivo e in vitro. Somente nos casos de fármacos que exibem uma elevada permeabilidade no trato gastrointestinal (TGI) as taxas de dissolução in vitro podem ser usadas para prever a taxa de absorção in vivo, já que a taxa de absorção é controlada exclusivamente pela taxa de liberação e sofre pouca ou nenhuma interferência das propriedades intrínsecas do fármaco ou das condições prevalecentes do TGI [2,3].…”

Section: Introductionunclassified

“…A compreensão dos fatores que interferem no mecanismo de liberação é importante na concepção e no desenvolvimento do material, pois auxilia a identificação de possíveis falhas, possibilita a garantia da qualidade e proteção da propriedade intelectual. O desenvolvimento da tecnologia associada à modificação de liberação de fármacos sofreu um incremento notório nas últimas décadas na tentativa de maximizar as vantagens inerentes às tais formas farmacêuticas [3,4,5].…”

Section: Introductionunclassified

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Silva¹,

Vilarinho²,

Barud

et al. 2016

Matéria (Rio J.)

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RESUMONas últimas décadas o uso de argilominerais nas áreas de Ciência e Engenharia de Materiais tem recebido notória atenção para a sua utilização no carreamento de fármacos. Dentre os diversos tipos de argilas, as fibrosas e as tubulares tem sido utilizadas na preparação de bionanocompósitos, devido as suas propriedades inerentes, como exemplo a elevada área superficial. Esta pesquisa visou o levantamento bibliográfico da utilização das argilas tubulares e fibrosas para o carreamento de fármacos. A busca por artigos foi realizado no banco de dados Web of Science, utilizando combinação dos termos: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, Imogolite and drug delivery, Palygoskite and drug delivery e Sepiolite and drug delivery. Foram encontrados o total de 36 artigos durante a pesquisa. Observouse que a maioria dos artigos utilizam as argilas em combinação com outros materiais (com formação de compósitos e blendas), principalmente polímeros, a fim de expandir as propriedades que melhoram a vetorização de insumos farmacêuticos ativos (IFAs), tais como a modificação do tamanho dos poros, do pH, da energia de ligação entre as moléculas, entre outros. Assim, evidencia-se que o interesse pela utilização das argilas no campo terapêutico tem aumentado, mostrando a relevância de pesquisas na área de medicamentos e materiais.Palavras-chave: argila fibrosa, argila tubular, argilominerais, carreamento de fármacos. ABSTRACTIn recent decades the use of clay minerals in the areas of Materials Science and Engineering has received notable attention for its use in carrying of drugs. Among the various types of clay, and fibrous tubes have been used in the preparation of bionanocompósitos due to their inherent properties, for example high surface area. This research aimed a review at the literature of the use of tubular and fibrous clays for the carrying of drugs. The search for articles was conducted in the Web of Science database, using combination of terms: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, imogolite and drug delivery, drug delivery and Palygoskite and Sepiolite and drug delivery. Found total of 36 articles during the search. It was observed that most of the clay articles used in combination with other materials (with formation of composites and blends), in particular polymers in order to extend the properties that improve the vectoring of active pharmaceutical ingredients (APIs), such as modification pore size, the pH, the binding energy between molecules, among others. Thus, it is clear that the interest in the use of clays in the therapeutic field has increased, showing the relevance of research in the area of drugs and materials.

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“…Among clays, bentonites are commonly used by the pharmaceutical industry as excipients, active substances or dispersal agents that fuli ll technological functions (MURRAY, 2006;RODRIGUES et al, 2013).…”

Section: Protective Effects Of Claymentioning

confidence: 99%

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

Riella

Nones

2017

Biotemas

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ResumoMedidas para o controle da alatoxina B 1 : uma breve revisão sobre o uso de lavonoides e argilas. A alatoxina B 1 (AFB 1 ) é uma das micotoxinas mais abundantes e tóxicas produzidas por cepas toxigênicas.Esta substância afeta a viabilidade celular, sendo capaz de induzir a morte, tanto de células humanas, quanto de células animais. Medidas vêm sendo adotadas para minimizar os danos causados pela AFB 1 , incluindo a utilização de lavonoides (compostos polifenólicos extraídos de plantas) e bentonitas (um tipo de argila). Nesta revisão, as características físico-químicas da AFB 1 e seus efeitos em diferentes tipos de células, in vitro e in vivo, foram abordados. Além disso, a capacidade de proteção celular a partir de substâncias e materiais naturais, tais como lavonoides e bentonita, foi brevemente descrita. Também relatamos os efeitos econômicos causados pelas micotoxinas e sugerimos alternativas (lavonoides e bentonita) para novas abordagens terapêuticas visando combater a toxicidade causada por estas substâncias (AFB 1 ).Palavras-chave: Alatoxina B 1 ; Argila; Flavonoides; Mecanismo de ação AbstractAlatoxin B 1 (AFB 1 ) is one of the most abundant and toxic mycotoxins produced by toxigenic strains. This substance affects cell viability, inducing cell death in several human and animal cells. Measures have been taken to minimize damage caused by AFB 1 , including the use of lavonoids (polyphenolic compounds extracted from plants) and bentonites (a type of clay). In this review, the physicochemical characteristics of AFB 1 and its effects on different cells are discussed. Furthermore, the cellular protective effects of lavonoids and bentonites are briely reviewed. Finally, the emerging view of the economic effects caused by mycotoxins is briely discussed, along with how lavonoids and bentonites might open new pathways to develop approaches to ight the toxic effects caused by alatoxins.

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The systems containing clays and clay minerals from modified drug release: A review

Cited by 186 publications

References 113 publications

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

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