The systemic inflammatory response syndrome

Characterization, epitope identification and mechanisms of the anti-septic capacity of monoclonal antibodies against macrophage migration inhibitory factor

“…To explore the mechanisms by which anti-MIF mAbs conferred protection, we discovered that the survival benefit of anti-MIF mAb treatment was associated with a reduction in the host systemic inflammatory responses, as shown by a decrease in the plasma concentrations of TNF-α and IL-6. Moreover, sepsis is also a generalized inflammatory response that involves organs distal to the locus of the initial infectious insult [26]. We discovered that the F11 anti-MIF mAb also protected the lung and kidney tissues of CLP mice.…”

The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

“…Sepsis is a generalized inflammatory response, which involves organ systems remote from the locus of the initial infectious insult [1]. One of the underlying mechanisms of sepsis is thought to be the oxidative damage due to the generation of free radicals.…”

Occurrence of nervous system involvement in SIRS

“…The role of pro-inflammatory (TNF-α, IFN-γ, IL-6) and anti-inflammatory (IL-4, IL-10) biomarkers has exhaustively been researched. However, the optimal treatment for SIRS is complicated by this multi-factorial nature of inciting agents and varied immune response in the clinical setting [4,5].…”