The systemic hallmarks of cancer

Paul, Doru

doi:10.20517/2394-4722.2020.63

Cited by 30 publications

(36 citation statements)

References 230 publications

(291 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is confirmed that APC acts as an antagonist of the Wnt signaling pathway in several cancer types, and the low expression of APC promotes tumor progression. Besides, it is also involved in other processes, like cell migration and adhesion, transcriptional activation, and apoptosis (29,30). The data and results from different databases and datasets showed that both METTL14 and ZC3H13 had high correlation coefficients with APC (R > 0.6, P < 0.05) ( Figures 8A-F).…”

Section: Co-expression Of Apc and Mettl14 Zc3h13mentioning

confidence: 98%

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

et al. 2020

View full text Add to dashboard Cite

ObjectivesRecently, an increasing number of studies have revealed that N6-methyladenosine (m6A) functions as a significant post-transcriptional modification which plays a critical role in the occurrence and progression of enriched tumors by regulating coding and non-coding RNA biogenesis. However, the biological function of m6A in breast cancer remains largely unclear.Materials and MethodsIn this study, we used a series of bioinformatic databases and tools to jointly analyze the expression of m6A methylation transferases (METTL3, METTL14, WTAP, RBM15, RBM15B and ZC3H13) and investigate the prognostic value of METTL14 and ZC3H13 in breast cancer. Besides, we analyzed the downstream carcinogenic molecular mechanisms related to METTL14 and ZC3H13 and their relationship with immune infiltration in breast tumor tissues.ResultsThe results showed that METTL14 and ZC3H13 were the down-regulated m6A methylation transferases in breast cancer. Survival outcome analysis suggested that abnormally low expression of METTL14 and ZC3H13 could predict unfavorable prognosis in four breast cancer subtypes. Moreover, their down-regulation was associated with ER-, PR- and triple-negative breast cancer patients, as well as tumor progression (increased Scarff, Bloom and Richardson grade status and Nottingham Prognostic Index classification). Co-expression analysis revealed that METTL14 and ZC3H13 had a strong positive correlation with APC, an antagonist of the Wnt signaling pathway, indicating they might cooperate in regulating proliferation, invasion, and metastasis of tumor cells. METTL14, ZC3H13, and APC expression levels had significant positive correlation with infiltrating levels of CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, and negative correlation with Treg cells in breast cancer.ConclusionsThis study demonstrated that down-regulation of METTL14 and ZC3H13 which act as two tumor suppressor genes was found in breast cancer and predicted poor prognosis. Their abnormal expression promoted breast cancer invasion by affecting pathways related to tumor progression and mediating immunosuppression.

show abstract

Section: Co-expression Of Apc and Mettl14 Zc3h13mentioning

confidence: 98%

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The constitutive expression of certain transcription factors enables cancer cells to gain these abilities. Just like organisms, cancer is highly complex and multi-layered which relies on a network of interactions at cellular, tissular and organismic levels [65]. The ability to break away from a primary tumour via metastasis to form multiple tumours in geographically separated tissues truly highlights its extensiveness.…”

Section: The Role Of Nrf2 In Cancermentioning

confidence: 99%

“…The ability to break away from a primary tumour via metastasis to form multiple tumours in geographically separated tissues truly highlights its extensiveness. Cancer achieves this by interacting with multiple body systems [65]. It is often described as a systemic disease whereby the tumour-body interaction results in the primary tumour colonising host organs by expressing several factors including transcription factors.…”

Section: The Role Of Nrf2 In Cancermentioning

confidence: 99%

Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

Jenkins

Gouge

2021

Antioxidants

View full text Add to dashboard Cite

Reactive oxygen species (ROS) play an important role in cell proliferation and differentiation. They are also by-products of aerobic living conditions. Their inherent reactivity poses a threat for all cellular components. Cells have, therefore, evolved complex pathways to sense and maintain the redox balance. Among them, Nrf2 (Nuclear factor erythroid 2-related factor 2) plays a crucial role: it is activated under oxidative conditions and is responsible for the expression of the detoxification machinery and antiapoptotic factors. It is, however, a double edge sword: whilst it prevents tumorigenesis in healthy cells, its constitutive activation in cancer promotes tumour growth and metastasis. In addition, recent data have highlighted the importance of Nrf2 in evading programmed cell death. In this review, we will focus on the activation of the Nrf2 pathway in the cytoplasm, the molecular basis underlying Nrf2 binding to the DNA, and the dysregulation of this pathway in cancer, before discussing how Nrf2 contributes to the prevention of apoptosis and ferroptosis in cancer and how it is likely to be linked to detoxifying enzymes containing selenium.

show abstract

“…cally, experimentally derived data assembled over more than a decade encourage the concept of the cancer system developed by the geographically differentiated cancer tissues (the primary tumor, the local, and the distant metastasis) [1,3].…”

mentioning

confidence: 99%

“…The systemic standpoint should be indefinite up to stage IV cancers clinically. When the tumors are localized in many cases, and systemic effects appear, a notable proportion of cancers is incurable [1,4].…”

mentioning

confidence: 99%

A Review on Systemic and New Cancer Hallmarks

Ingole¹,

Petle²,

Dhoke³

et al. 2021

Act Scie Canbio

View full text Add to dashboard Cite

The body system is dependent on each other through communication, cancer development can be supported by the new cancerinduced pathological systemic networks (CISPN), and the entire organism is "cancerized." The significant anomaly in the transition of epithelial cells to mesenchymal cells plays a vital role in neural crest migration. The metastatic program follows a transformed cellular communication process that, activated once, causes dispersed tumors at a distance from the original site. This review aims to provide an idea of various systemic and new hallmarks and several altered networking processes that eventually end up causing cancer.

show abstract

The systemic hallmarks of cancer

Cited by 30 publications

References 230 publications

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

A Review on Systemic and New Cancer Hallmarks

Contact Info

Product

Resources

About