The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks

Cicardi, Marco; Gardinali, M; Bisiani, Giuliana; Rosti, Alberto; Allavena, Paola; Agostoni, A

doi:10.7326/0003-4819-113-6-475

Cited by 81 publications

(43 citation statements)

References 6 publications

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“…These include reports of increased LTE4 (leukotriene E4) urinary excretion (5), increased IL-2 receptor positive cells (6) and increased CD8 cells surrounding endothelial cells (7). Complement levels are usually normal (3).…”

Section: A 24-year-old Man Was Admitted To Our Hospital With Circulatmentioning

confidence: 99%

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Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

Dhir¹,

Arya²,

Malav³

et al. 2007

Intern. Med.

109

115

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Section: A 24-year-old Man Was Admitted To Our Hospital With Circulatmentioning

confidence: 99%

“…Ch a r a c t e r i s t i c s o (12,13). There was accompanying generalized edema in 37 cases with weight gain reported in 10 cases ranging from 2-29 kg (6,9,(14)(15)(16)(17). Some reports described the edema to be non pitting (4,14).…”

Section: A 24-year-old Man Was Admitted To Our Hospital With Circulatmentioning

confidence: 99%

Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

Dhir¹,

Arya²,

Malav³

et al. 2007

Intern. Med.

109

115

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show abstract

“…A similar condition has been described in patients treated with recombinant interleukin-2, but the etiopathogenetic mechanism of this syndrome remains unknown. 39 Two of the 3 patients we observed died within 5 years of diagnosis; the third did not return for follow-up.…”

mentioning

confidence: 98%

Angioedema without urticaria: a large clinical survey

Zingale¹,

Beltrami²,

Zanichelli³

et al. 2006

Canadian Medical Association Journal

186

158

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A ngioedema -a self-limited, localized swelling that involves subcutaneous tissues or mucosa -can involve the face and other areas. Skin colour is usually unchanged, although it may be heralded by erythema marginatum. There is no burning sensation and itchiness is generally absent. Lesions tend to be large and without clear demarcation; most resolve within 2 or 3 days. 1Frequently the result of the release of histamine, angioedema is often associated with urticarial flares (hives; the association is often called urticaria-angioedema syndrome) and responds to antihistamines and corticosteroids.2 Occasionally, angioedema occurs without urticaria, does not respond to drugs against allergies and tends to last 5-7 days -for example, when it is caused by a deficiency in plasma of C1 esterase inhibitor (C1Inh).To investigate and form classifications for different forms of angioedema unaccompanied by urticaria, we analyzed 929 consecutive patients referred to our university hospital over an 11-year period (January 1993 through December 2003). MethodsOur outpatient clinic for angioedema is a tertiary-level centre where patients are referred mostly by specialists. All clinic patients with a history of recurrent angioedema without major urticaria between January 1993 and December 2003 were considered for the study.From each patient, we obtained a clinical history with information about allergies and their relation to potential causative agents (e.g., foods, drugs, chemicals) and carried out a complete physical examination. We obtained sinus and dental radiographs as well as test results for blood cell count, serum protein electrophoresis, erythrocyte sedimentation rate, Creactive protein, hepatic enzymes, renal function, thyroid function and anti-tissue antibodies (antinuclear antibodies and antibodies to extractable nuclear antigens, to doublestranded DNA, to thyroglobulin and to thyroperoxidase). Stool examinations (for ova and parasites) and urinanalyses were carried out, and pharyngeal and urine samples were cultured. Further specific analyses were performed if deemed necessary.If all test results were negative, response to long-term H1-

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“…However the pathogenesis of SCLS is still unknown. Involvement of interleukin-2, classic pathway complement or stimulation of 5-lipooxygenase-pathway have been suggested [5-7]. The relationship between monoclonal protein and SCLS has also not been clarified.…”

Section: Resultsmentioning

confidence: 99%

Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary thermodilution technique for volume management

Saugel

Umgelter

Fortin

et al. 2010

Scandinavian Journal of Trauma, Resuscitation and Emergency Med

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Systemic Capillary Leak Syndrome (SCLS) is a rare disorder characterized by increased capillary hyperpermeability leading to hypovolemic shock due to a markedly increased shift of fluid and protein from the intravascular to the interstitial space. Hemoconcentration, hypoalbuminemia and a monoclonal gammopathy are characteristic laboratory findings. Here we present a patient who suffered from SCLS with hypovolemic shock and compartment syndrome of both lower legs and thighs. Volume and catecholamine management was guided using transpulmonary thermodilution. Extended hemodynamic monitoring for volume and catecholamine management as well as monitoring of muscle compartment pressure is of crucial importance in SCLS patients.

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The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks

Cited by 81 publications

References 6 publications

Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

Angioedema without urticaria: a large clinical survey

Systemic Capillary Leak Syndrome associated with hypovolemic shock and compartment syndrome. Use of transpulmonary thermodilution technique for volume management

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