The system of cerebrospinal fluid-contacting neurons.

Vigh-Teichmann, I.; Vígh, B.

doi:10.1679/aohc.46.427

Cited by 127 publications

(68 citation statements)

References 82 publications

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“…Coronet cells are characterized by an apical crown of globule-tipped cilia protruding into the ventricle 16 ( Fig. 3a), whereas the CSF-contacting neurons are bipolar neurons with a knob-like structure; their morphology resembles that of photoreceptor cells in the developing retina 18 . In a previous study, we demonstrated that OPN5-positive CSFcontacting neurons in the quail hypothalamus are a type of deep-brain photoreceptors that mediate the photoperiodic response 10 .…”

Section: Resultsmentioning

confidence: 99%

The saccus vasculosus of fish is a sensor of seasonal changes in day length

et al. 2013

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The pars tuberalis of the pituitary gland is the regulatory hub for seasonal reproduction in birds and mammals. Although fish also exhibit robust seasonal responses, they do not possess an anatomically distinct pars tuberalis. Here we report that the saccus vasculosus of fish is a seasonal sensor. We observe expression of key genes regulating seasonal reproduction and rhodopsin family genes in the saccus vasculosus of masu salmon. Immunohistochemical studies demonstrate that all of these genes are expressed in the coronet cells of the saccus vasculosus, suggesting the existence of a photoperiodic signalling pathway from light input to neuroendocrine output. In addition, isolated saccus vasculosus has the capacity to respond to photoperiodic signals, and its removal abolishes photoperiodic response of the gonad. Although the physiological role of the saccus vasculosus has been a mystery for several centuries, our findings indicate that the saccus vasculosus acts as a sensor of seasonal changes in day length in fish.

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Section: Resultsmentioning

confidence: 99%

The saccus vasculosus of fish is a sensor of seasonal changes in day length

et al. 2013

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“…KolmerAgduhr neurons are hair cell-like sensory neurons that contact the central canal and send out ipsilateral ascending axons (37). Interestingly, the sensory apparatus of Kolmer-Agduhr cells directly contacts Reissner's fiber, a mucous strand in the neural canal in all vertebrates and in the chordate amphioxus (38), indicative of an ancient origin of Kolmer-Agduhr-like neurons.…”

Section: Discussion Cellular-resolution Expression Atlases For Complementioning

confidence: 99%

Whole-organism cellular gene-expression atlas reveals conserved cell types in the ventral nerve cord of Platynereis dumerilii

Vergara

Bertucci

Hantz

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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The comparative study of cell types is a powerful approach toward deciphering animal evolution. To avoid selection biases, however, comparisons ideally involve all cell types present in a multicellular organism. Here, we use image registration and a newly developed "Profiling by Signal Probability Mapping" algorithm to generate a cellular resolution 3D expression atlas for an entire animal. We investigate three-segmented young worms of the marine annelid Platynereis dumerilii, with a rich diversity of differentiated cells present in relatively low number. Starting from whole-mount expression images for close to 100 neural specification and differentiation genes, our atlas identifies and molecularly characterizes 605 bilateral pairs of neurons at specific locations in the ventral nerve cord. Among these pairs, we identify sets of neurons expressing similar combinations of transcription factors, located at spatially coherent anterior-posterior, dorsal-ventral, and mediallateral coordinates that we interpret as cell types. Comparison with motor and interneuron types in the vertebrate neural tube indicates conserved combinations, for example, of cell types cospecified by Gata1/2/3 and Tal transcription factors. These include V2b interneurons and the central spinal fluid-contacting Kolmer-Agduhr cells in the vertebrates, and several neuron types in the intermediate ventral ganglionic mass in the annelid. We propose that Kolmer-Agduhr cell-like mechanosensory neurons formed part of the mucociliary sole in protostome-deuterostome ancestors and diversified independently into several neuron types in annelid and vertebrate descendants.gene-expression atlas | evo-devo | cell-type evolution | Kolmer-Agduhr cells | ProSPr

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“…Sizes are shown in kDa. (7). The presence of TDa in the avian pineal gland is of special interest because outer segments in avian pineal photosensory elements are not well differentiated (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…We were interested in the precise localization of TD in vertebrate retinae and also in determining whether it was present in vertebrate pineal complexes. The latter issue is of interest because it will provide some insight into the evolution of the vertebrate pineal gland from a photosensitive organ in lower forms (6), which contains the retinal proteins opsin and S antigen (7,8), to a nonphotosensitive organ in mammals, which contains only some retinal proteins including rhodopsin kinase and S antigen (9-11). TDa in the mammalian pineal gland could play an important role in neural control mechanisms.…”

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confidence: 99%

alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates.

Veen

Östholm

Gierschik

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

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Antiserum against the a subunit of bovine rod-outer-segment transducin was used in an immunocytochemical study that identified the protein in retina (human, baboon, owl monkey, cow, rat, quail, newt, frog, salmon, eel, and lamprey), pineal organ (quail, newt, frog, salmon, eel, and lamprey), and parapineal organ (salmon and lamprey). No reaction was observed in the cow or rat pineal organ or the eel parapineal organ. The immunoreaction was very strong in outer segments but weak in perikarya. Immunoblots of crude tissue extracts of bovine rod-outer-segment membranes and frog and fish retina revealed a 39-kDa immunopositive band. The fish retina also contained two additional bands of mass 43 kDa and 25 kDa. Only the 43-kDa band was present in the fish pineal organ, which is photosensitive. This raises the possibility that the 43-kDa a transducin-immunopositive molecule present in the fish pineal organ and retina may be involved in phototransduction.Transducin (TD) is a member of a family of heterotrimeric GTP-binding (G) An important development in knowledge of G proteins has been a better understanding of their subunits. It appears that the ,B subunits (35 kDa) of all G proteins are similar but that the a subunit (39-42 kDa) of each is unique (4, 5).The unique nature of the a subunit of TD (TDa) makes it possible to specifically identify TD immunohistochemically. We were interested in the precise localization of TD in vertebrate retinae and also in determining whether it was present in vertebrate pineal complexes. The latter issue is of interest because it will provide some insight into the evolution of the vertebrate pineal gland from a photosensitive organ in lower forms (6), which contains the retinal proteins opsin and S antigen (7,8), to a nonphotosensitive organ in mammals, which contains only some retinal proteins including rhodopsin kinase and S antigen (9-11). TDa in the mammalian pineal gland could play an important role in neural control mechanisms. To investigate these issues, we used a highly specific antiserum against TDa, which does not recognize purified a subunits of other G proteins (12). MATERIALS AND METHODSImmunochemistry. TD was purified from bovine rod-outersegment membranes (2); TDc. was purified by blue Sepharose chromatography (12). Rabbits were immunized with purified (>95%) TDa as described (4, 12); the antiserum used in this study is GI-2/10-12-84.The details of NaDodSO4/PAGE and immunoblotting techniques and the sources of all materials have been given (4, 12). Crude plasma membrane preparations were made by either sonication or teflon/glass homogenization of tissues, followed by 10,000 x g centrifugation. The crude membrane pellet was resuspended in water and NaDodSO4/PAGE sample buffer (4), boiled for 2 to 3 min, and cooled before loading on gels.Immunohistochemistry. Light-adapted retinae and pineal organs of adult human, baboon (Papio), owl monkey (Aotes), cattle (Bos taurus), rat (Wistar rat), quail (Coturnix coturnix japonica), newt (Triturus vulgaris), frog (Rana es...

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The system of cerebrospinal fluid-contacting neurons.

Cited by 127 publications

References 82 publications

The saccus vasculosus of fish is a sensor of seasonal changes in day length

The saccus vasculosus of fish is a sensor of seasonal changes in day length

Whole-organism cellular gene-expression atlas reveals conserved cell types in the ventral nerve cord of Platynereis dumerilii

alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates.

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