The Synthetic Elicitor 2-(5-Bromo-2-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid Links Plant Immunity to Hormesis

Rodriguez-Salus, Melinda; Bektaş, Yasemin; Schroeder, Mercedes; Knoth, Colleen; vụ, Trang tin tổng hợp nhất Công nghiệp dịch; Roberts, Philip A.; Kaloshian, Isgouhi; Eulgem, Thomas

doi:10.1104/pp.15.01058

Cited by 27 publications

(26 citation statements)

References 83 publications

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“…The stimulatory effect seen at very low doses of the response curve (region A) is termed hormesis, a poorly understood but likely universal response . A recent plant study seeking a mechanistic explanation showed that hormetic doses of a disease resistance‐inducing chemical enhanced Arabidopsis root growth and suppressed the expression of photosynthesis‐ and respiration‐related genes, while higher sublethal doses induced a very different suite of defense‐related transcripts . This finding, along with the fact that reduced herbicide applications can select for resistance in Avena fatua and other species supports the idea that hormetic and sublethal doses are part of a continuum that induces overlapping adaptive responses like NTSR.…”

Section: Where Do Ntsr Plants Come From?mentioning

confidence: 99%

Stress‐induced evolution of herbicide resistance and related pleiotropic effects

Dyer

2018

Pest Management Science

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Herbicide-resistant weeds, especially those with resistance to multiple herbicides, represent a growing worldwide threat to agriculture and food security. Natural selection for resistant genotypes may act on standing genetic variation, or on a genetic and physiological background that is fundamentally altered because of stress responses to sublethal herbicide exposure. Stress-induced changes include DNA mutations, epigenetic alterations, transcriptional remodeling, and protein modifications, all of which can lead to herbicide resistance and a wide range of pleiotropic effects. Resistance selected in this manner is termed systemic acquired herbicide resistance, and the associated pleiotropic effects are manifested as a suite of constitutive transcriptional and post-translational changes related to biotic and abiotic stress adaptation, representing the evolutionary signature of selection. This phenotype is being investigated in two multiple herbicide-resistant populations of the hexaploid, self-pollinating weedy monocot Avena fatua that display such changes as well as constitutive reductions in certain heat shock proteins and their transcripts, which are well known as global regulators of diverse stress adaptation pathways. Herbicide-resistant populations of most weedy plant species exhibit pleiotropic effects, and their association with resistance genes presents a fertile area of investigation. This review proposes that more detailed studies of resistant A. fatua and other species through the lens of plant evolution under stress will inform improved resistant weed prevention and management strategies. © 2018 Society of Chemical Industry.

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Section: Where Do Ntsr Plants Come From?mentioning

confidence: 99%

Stress‐induced evolution of herbicide resistance and related pleiotropic effects

Dyer

2018

Pest Management Science

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“…This pattern resembles the concept of hormesis often deployed by toxicologists to describe the response to toxins, where exposure to a low dose is beneficial while a higher dose results toxicity due to overcompensation in response to disruption of homeostasis 53 . While tissue-specific hormetic responses have been described in flies, where a virus-acquired cytokine relays ageing 54 , and examples of abiotic factors or signalling molecules affecting peas and aphid infestation 55 , immunity in plants 56,57 , life-span in malaria-transmitting Anopheles 58 , and larval development in Black Cutworm 59 , this example here could be the first involving a eukaryotic host-pathogen relationship. The underlying factor remains to be elucidated but C. neoformans ’ highly immunogenic capsule seems to be an excellent candidate 48 .…”

Section: Discussionmentioning

confidence: 92%

Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

Lyons

Softley

Balfour

et al. 2019

Preprint

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29Pathogenic yeast species can cause life-threatening infections in humans. The two leading 30 yeast pathogens, Candida albicans and Cryptococcus neoformans, cause systemic infections 31 in >1.4 million patients world-wide with mortality rates approaching 75%. It is thus 32 imperative to study fungal virulence mechanisms, stress response pathways, and the efficacy 33 of antifungal drugs. This is commonly done using mammalian models. To address ethical and 34 practical concerns, invertebrate models, such as wax moth larvae, nematodes, or flies, have 35 been introduced over the last two decades. To address short-comings in existing invertebrate 36 host models, we developed fifth instar caterpillars of the Tobacco Hornworm moth Manduca 37 sexta as a novel host model for the study of fungal virulence and drug efficacy. These 38 caterpillars can be raised at standardised conditions, maintained at 37˚C, can be injected with 39 defined amounts of yeast cells, and are susceptible to the most threatening yeast pathogens, 40 including C. albicans, C. neoformans, C. auris, and C. glabrata. Infected caterpillars can be 41 rescued by treatment with commonly deployed antifungal drugs and importantly, fungal 42 burden can be assessed daily throughout the course of infection in a single caterpillar's faeces 43 and hemolymph. Notably, these animals are large enough so that weight provides a reliable 44 and reproducible measure of fungal virulence. This model combines a suite of parameters that 45 recommend it for the study of fungal virulence. 46 47 50 tuberculosis 1 . The leading yeast pathogens, Candida albicans and Cryptococcus neoformans, 51 together account for >1,400,000 life-threatening infections world-wide with mortality rates 52 approaching 75% 1 . Candidemia, most commonly caused by C. albicans, is the fourth most 53 common cause of nosocomial blood stream infections, only surpassed by infections with 54Staphylococci and Enterococcus spp. Disturbingly, candidemia incidence rates are on the 55 rise. Within less than ten years, incidence rates increased by 36% 2 . Although cryptococcosis 56 incidence rates are on the decline in North America, this AIDS-defining illness is responsible 57 for 15% of all AIDS-related deaths world-wide 2,3 . This already dire situation is further 58 confounded by the emergence of drug resistant yeast species. Patients at risk of developing 59 invasive candidemia are often prophylactically treated with fluconazole, while the 60 echinocandins are considered a first line defence strategy 4 . Yet, C. glabrata, the most 61 3 common non-albicans Candida species associated with nosocomial blood stream infections 5 , 62 is intrinsically less susceptible to azole drugs and acquires resistance to echinocandins 63 rapidly 6 . The rapid global spread of multi-drug resistant C. auris has further exacerbated the 64 threat posed by fungi. C. auris was first reported in 2009 in Japan 7 . In 2015, C. auris arrived 65 in Europe causing an outbreak involving 72 patients in a cardio-thoracic hospital i...

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“…Viruses are biotrophic parasites and important pathogens of plants and cause a range of severe plant diseases and immense annual losses of yield. To date, chemical reagents are widely used to prevent or control plant diseases in agriculture [1]. However, the extensive use of agrochemicals has caused pernicious pesticide residues and environmental pollution, declined crop quality, and threatened human health.…”

Section: Backgroudmentioning

confidence: 99%

Ultrahigh-activity immune inducer from Endophytic Fungi induces tobacco resistance to virus by SA pathway and RNA silencing

et al. 2020

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Background: Plant viruses cause severe economic losses in agricultural production. An ultrahigh activity plant immune inducer (i.e., ZhiNengCong, ZNC) was extracted from endophytic fungi, and it could promote plant growth and enhance resistance to bacteria. However, the antiviral function has not been studied. Our study aims to evaluate the antiviral molecular mechanisms of ZNC in tobacco. Results: Here, we used Potato X virus (PVX), wild-type tobacco and NahG transgenic tobacco as materials to study the resistance of ZNC to virus. ZNC exhibited a high activity in enhancing resistance to viruses and showed optimal use concentration at 100-150 ng/mL. ZNC also induced reactive oxygen species accumulation, increased salicylic acid (SA) content by upregulating the expression of phenylalanine ammonia lyase (PAL) gene and activated SA signaling pathway. We generated transcriptome profiles from ZNC-treated seedlings using RNA sequencing. The first GO term in biological process was positive regulation of post-transcriptional gene silencing, and the subsequent results showed that ZNC promoted RNA silencing. ZNC-sprayed wild-type leaves showed decreased infection areas, whereas ZNC failed to induce a protective effect against PVX in NahG leaves. Conclusion: All results indicate that ZNC is an ultrahigh-activity immune inducer, and it could enhance tobacco resistance to PVX at low concentration by positively regulating the RNA silencing via SA pathway. The antiviral mechanism of ZNC was first revealed in this study, and this study provides a new antiviral bioagent.

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The Synthetic Elicitor 2-(5-Bromo-2-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid Links Plant Immunity to Hormesis

Cited by 27 publications

References 83 publications

Stress‐induced evolution of herbicide resistance and related pleiotropic effects

Stress‐induced evolution of herbicide resistance and related pleiotropic effects

Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

Ultrahigh-activity immune inducer from Endophytic Fungi induces tobacco resistance to virus by SA pathway and RNA silencing

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