The Synthetic Antimicrobial Peptide Derived From Melittin Displays Low Toxicity and Anti-infectious Properties

Rad, Parisa Mansouri; Rahbarnia, Leila; Safary, Azam; Shadi-Dizaji, Azizeh; Maani, Zahra

doi:10.1007/s12602-023-10066-6

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…However, it is worth noting that the hemolytic activity of the M2 analog was less than that of M1 at a concentration of 16 μg/mL. [ 50 ]…”

Section: Mlt Derivativesmentioning

confidence: 99%

“…For example, some researchers have synthesized analogs of MLT that have been shown to have lower hemolytic activity while retaining their ability to kill cancer cells. [ 48–50 ] Another solution is to use targeted delivery systems to specifically deliver MLT to cancer cells while minimizing its exposure to healthy cells. This can be achieved through the use of nanoparticle (NP)‐based drug delivery systems that can selectively target cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

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Melittin (MLT), a peptide containing 26 amino acids, is a key constituent of bee venom. It comprises ∼40%–60% of the venom's dry weight and is the main pricing index for bee venom, being the causative factor of pain. The unique properties of MLT extracted from bee venom have made it a very valuable active ingredient in the pharmaceutical industry as this cationic and amphipathic peptide has propitious effects on human health in diverse biological processes. It has the ability to strongly impact the membranes of cells and display hemolytic activity with anticancer characteristics. However, the clinical application of MLT has been limited by its severe hemolytic activity, which poses a challenge for therapeutic use. By employing more efficient mechanisms, such as modifying the MLT sequence, genetic engineering, and nano‐delivery systems, it is anticipated that the limitations posed by MLT can be overcome, thereby enabling its wider application in therapeutic contexts. This review has outlined recent advancements in MLT's nano‐delivery systems and genetically engineered cells expressing MLT and provided an overview of where the MLTMLT's platforms are and where they will go in the future with the challenges ahead. The focus is on exploring how these approaches can overcome the limitations associated with MLT's hemolytic activity and improve its selectivity and efficacy in targeting cancer cells. These advancements hold promise for the creation of innovative and enhanced therapeutic approaches based on MLT for the treatment of cancer.

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“…However, it is worth noting that the hemolytic activity of the M2 analog was less than that of M1 at a concentration of 16 μg/mL. [ 50 ]…”

Section: Mlt Derivativesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

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A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs

Fong-Coronado,

Ramirez,

Quintero-Hernández

et al. 2024

J Membrane Biol

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Scorpion venoms have proven to be excellent sources of antimicrobial agents. However, although many of them have been functionally characterized, they remain underutilized as pharmacological agents, despite their evident therapeutic potential. In this review, we discuss the physicochemical properties of short scorpion venom antimicrobial peptides (ssAMPs). Being generally short (13–25 aa) and amidated, their proven antimicrobial activity is generally explained by parameters such as their net charge, the hydrophobic moment, or the degree of helicity. However, for a complete understanding of their biological activities, also considering the properties of the target membranes is of great relevance. Here, with an extensive analysis of the physicochemical, structural, and thermodynamic parameters associated with these biomolecules, we propose a theoretical framework for the rational design of new antimicrobial drugs. Through a comparison of these physicochemical properties with the bioactivity of ssAMPs in pathogenic bacteria such as Staphylococcus aureus or Acinetobacter baumannii, it is evident that in addition to the net charge, the hydrophobic moment, electrostatic energy, or intrinsic flexibility are determining parameters to understand their performance. Although the correlation between these parameters is very complex, the consensus of our analysis suggests that there is a delicate balance between them and that modifying one affects the rest. Understanding the contribution of lipid composition to their bioactivities is also underestimated, which suggests that for each peptide, there is a physiological context to consider for the rational design of new drugs. Graphical Abstract

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Rational design of hybrid peptide with high antimicrobial property derived from Melittin and Lasioglossin

Nabizadeh,

Rahbarnia,

Nowrozi

et al. 2023

Journal of Biomolecular Structure and Dynamics

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The Synthetic Antimicrobial Peptide Derived From Melittin Displays Low Toxicity and Anti-infectious Properties

Cited by 6 publications

References 35 publications

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Immunomodulatory activities and biomedical applications of melittin and its recent advances

A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs

Rational design of hybrid peptide with high antimicrobial property derived from Melittin and Lasioglossin

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