The Synthesis of Some Alkyl and Dialkylaminoalkyl Esters of 3-Amino-4-fluorobenzoic Acid

Abstract

The diacetate was prepared by refluxing the diphenol with acetic anhydride in pyridine. The product was obtained as white plates from acetic acid, m. p. 234°.Anal.» Caled, for CMH220«: C, 80.72; H, 4.93. Found: C, 80.79; H.4.79.The dipropionate was prepared by refluxing the diphenol for two hours with propionyl chloride. The hot mixture was poured on ice, the product collected and recrystallized from acetic acid as fine plate-like white crystals, m. p. 185-186°.

Solid acid catalysts for fluorotoluene nitration using nitric acid

“…Fluoronitrotoluenes are important due to their application as intermediates in the synthesis of antibacterial antibiotics, herbicides, drug intermediates, certain heterocyclics and also as electrophiles. [3][4][5][6][7][8][9] Major drawbacks of conventional nitration using fuming nitric acid are low conversion and poor selectivity. [10][11][12] In recent years there has been a spate of activity aimed at the development of new nitration methods using solid acid catalysts; however very limited success has been achieved.…”