“…1 To date, extensive synthetic efforts have resulted in the successful total syntheses of atisine, 2,3 veatchine, 3−5 garryine, 3,5 delphinine, 6 talatisamine, 7 napelline, 8 chasmanine, 9 nominine, 10 and neofinaconitine. 11 As shown in Figure 1, the denudatine family is a group of diterpenoid alkaloids containing more than 30 compounds, such as denudatine (1), 12,13 lepenine (2), 12,14 stenocarpine (3), 15 dictysine (4), 16 aconicarmine (5), 17 and kirinine B (6). 18 These compounds are especially interesting because they are chemical 9 and biosynthetic 19 precursors of aconitine-type alkaloids, which are well-known for their potent bioactivity such as inhibition of the voltage-dependent sodium ion channel.…”