The synthesis of carbocyclic aromatic systems

One-pot formal synthesis of biorenewable terephthalic acid from methyl coumalate and methyl pyruvate

“…Researchers have efficiently generated aromatic systems through variegated approaches, 10,11 including the acclaimed Diels-Alder reaction which has long been instrumental in building complexity through domino reaction sequences. [12][13][14] Furthermore, captodative olefins with stabilization arising from an electron-rich and an electron-poor substituent appended to an alkene 15 have been successfully incorporated in radical additions, 16 Friedel-Crafts reactions, 17 2,3-cycloadditions, 18 and Diels-Alder transformations.…”