The synthesis of an octasubstituted monohydroxylated phthalocyanine designed to investigate the effect of the presence of active moieties

Abstract

A monohydroxylated octasubstituted phthalocyanine, aimed at being used as a synthon for further conjugation, has been designed to offer rigorous comparison conditions to study the effect of the presence of an active moiety, compared to its non-functionalized symmetric analogs. After the validation of the concept using computational methods, the designed phthalocyanine was prepared and exhibited the expected suitable electronic absorption properties. Biotin conjugation was performed.

Hydrogen-bond-driven supramolecular helical assembly of a coumarin-substituted phthalonitrile derivative: synthesis andin vitroanticancer activity against colorectal adenocarcinoma

“…4(a), which shows that the conjugation does not extend over the entire molecular system due to the presence of a flexible C-O-C bond (Ko ¨c ¸et al, 2016). Both of the CN bond lengths of about 1.15 A ˚are within normal values and are in good agreement with previously reported structures (O ¨nal et al, 2018;Tarakci et al, 2015;Zorlu et al, 2013Zorlu et al, , 2014Kumru et al, 2012;Ayari et al, 2019). It is worth mentioning that the weak C-HÁ Á ÁO hydrogen-bonding interactions (C22Á Á ÁO2 = 3.139 A ˚and C23Á Á ÁO2 = 3.180 A ˚; Fig.…”