The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

Hein, Christopher D.; Liu, Xin Ming; Chen, Fu; Cullen, D. M.; Wang, Dong

doi:10.1002/mabi.201000205

Cited by 13 publications

(9 citation statements)

References 47 publications

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“…2A). This effect was also demonstrated in our previous studies (23, 25); however, it is not clear why the increase of MW also improve the binding capacity PPi-PEG. One explanation is that, since the increase in MW also increases the number of PPi molecules per polymer chain, a higher MW polymer would contain more PPi per chain to provide stronger binding to HA than a lower MW polymer, due to the multivalent binding nature of these copolymers.…”

Section: Discussionsupporting

confidence: 80%

The Development of Drug-Free Therapy for Prevention of Dental Caries

et al. 2014

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Purpose The purpose of this study was to develop a novel, drug-free therapy that can reduce the over-accumulation of cariogenic bacteria on dental surfaces. Method We designed and synthesized a polyethylene glycol (PEG)-based hydrophilic copolymer functionalized with a pyrophosphate (PPi) tooth-binding anchor using “click” chemistry. The polymer was then evaluated for hydroxyapatite (HA) binding kinetics and capability of reducing bacteria adhesion to artificial tooth surface. Results The PPi-PEG copolymer can effectively inhibit salivary protein adsorption after rapid binding to an artificial tooth surface. As a result, thein vitro S. mutans adhesion study showed that the PPi-PEG copolymer can inhibit saliva protein-promotedS. mutans adhesion through the creation of a neutral, hydrophilic layer on the artificial tooth surface. Conclusion The results suggested the potential application of a PPi-PEG copolymer as a drug-free alternative to current antimicrobial therapy for caries prevention.

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Section: Discussionsupporting

confidence: 80%

The Development of Drug-Free Therapy for Prevention of Dental Caries

et al. 2014

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“…This mobile, nanostructural feature of the molecular necklace can be utilized for modulating receptor‐mediated cellular functions by facilitating the interactions of bioactive agent‐ or ligand‐conjugated α‐CDs in hydrogels with receptor sites of proteins on the plasma cell membranes (e.g., cell‐adhesion via integrin binding to ECM proteins) 19, 20, 28. α‐CD has primarily been employed as a nanoscale drug delivery vehicle24, 28, 29, 45 and as a crosslinking agent to create hydrogels for fibroblast culture,22, 32, 46 cartilage27, 33 and bone47, 48 tissue engineering. However, critical features such as the modular design, cytocompatibility,45 ease of modification,26 enhanced cell‐material interactions,19, 20, 28 and controlled presentation of biological ligands via user‐controlled dethreading,30–33 enable application of this powerful hydrogel tool for directed stem cell differentiation and tissue production as demonstrated in the present studies.…”

Section: Resultsmentioning

confidence: 99%

Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation

Singh

Zhan

et al. 2012

Adv Funct Materials

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Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biological or chemical ligands, which often changes the fundamental structural properties of the material. Here, a simple modular biomaterial design strategy is reported that employs functional cyclodextrin nanobeads threaded onto poly(ethylene glycol) (PEG) polymer necklaces to form multifunctional hydrogels. Nanobeads with desired chemical or biological functionalities can be simply threaded onto the PEG chains to form hydrogels, creating an accessible platform for users. The design and synthesis of these multifunctional hydrogels are described, structure‐property relationships are elucidated, and applications ranging from stem cell culture and differentiation to tissue engineering are demonstrated.

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“…Hydroxyapatite-based biodegradable mPEG-PLGA nanoparticles of risedronate were found to have increased bioavailability and significant effects on bone turnover indicators in an osteoporotic model system ( Rawat et al, 2016 ). In another technique, the Wang group created a polyrotaxane using click chemistry, allowing varying numbers of BP molecules and addition of imaging or additional therapeutic agents ( Hein et al, 2010 ).…”

Section: Bisphosphonate Conjugatesmentioning

confidence: 99%

Bisphosphonate conjugation for bone specific drug targeting

et al. 2018

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Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bone remains an important goal for achieving effective treatments. Drug targeting strategies have improved drug localization to bone by taking advantage of the high mineral concentration unique to the bone hydroxyapatite matrix, as well as tissue-specific cell types. The bisphosphonate molecule class binds specifically to hydroxyapatite and inhibits osteoclast resorption of bone, providing direct treatment for degenerative bone disorders, and as emerging evidence suggests, cancer. These bone-binding molecules also provide the opportunity to deliver other drugs specifically to bone by bisphosphonate conjugation. Bisphosphonate bone-targeted therapies have been successful in treatment of osteoporosis, primary and metastatic neoplasms of the bone, and other bone disorders, as well as refining bone imaging. In this review, we focus upon the use of bisphosphonate conjugates with antineoplastic agents, and overview bisphosphonate based imaging agents, nanoparticles, and other drugs. We also discuss linker design potential and the current state of bisphosphonate conjugate research progress. Ongoing investigations continue to expand the possibilities for bone-targeted therapeutics and for extending their reach into clinical practice.

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The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

Cited by 13 publications

References 47 publications

The Development of Drug-Free Therapy for Prevention of Dental Caries

The Development of Drug-Free Therapy for Prevention of Dental Caries

Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation

Bisphosphonate conjugation for bone specific drug targeting

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