The Synthesis of 6-Formylsalicylic Acid, Esters of 6-Bromomethylsalicylic Acid, and Related Substances

Eliel, Ernest L.; Rivard, Donald E.; Burgstahler, Albert W.

doi:10.1021/jo50018a010

Cited by 29 publications

(5 citation statements)

References 9 publications

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“…6-Methylaspirin was prepared as described previously (Eliel, Rivard & Burgstahler, 1953 (Fo2), and c(6) were used in the refinement. Data were corrected for C (7) C (8) background, Lorentz, polarization and absorption c(9) effects.…”

mentioning

confidence: 99%

2-Acetoxy-6-methylbenzoic acid

Fronczek¹,

Merrill²,

Gandour³

1982

Acta Crystallogr Sect B

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mentioning

confidence: 99%

2-Acetoxy-6-methylbenzoic acid

Fronczek¹,

Merrill²,

Gandour³

1982

Acta Crystallogr Sect B

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“…All chemicals were purchased from either Wako or Aldrich Chemical Company. Compounds 3 and 5a were prepared by published methods [15,16]. Preparative and analytical TLC were performed on Merck Kieselgel 60F 254 precoated glass plates (0.5 mm and 0.25 mm, respectively).…”

Section: Methodsmentioning

confidence: 99%

Bioconversion of Proposed Precursors into Theobroxide and Related Compounds

Takahashi

Elkhateeb

et al. 2011

Natural Product Communications

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We have previously reported a tetraketide origin for theobroxide and its related compound. In the present study, bioconversion of natural and deuterium-labeled precursors of this proposed biosynthetic pathway by Lasiodipoldia theobromae was investigated. Theobroxide was quantified after bioconversion from each proposed precursor. The transformation of the isotopically labeled precursor to products was tracked by 2H NMR measurement.

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“…All other materials were reagent grade unless otherwise specified. 2-Carbomethoxy-3-nitro-benzoic acid, 9 2-carbomethoxy-3-nitro-benzoyl chloride, 2-azidocarbonyl-benzoic acid methyl ester, 10 2-amino-6-nitrobenzoic acid methyl ester, 11 2,6-diamino benzoic acid methyl ester, 12 2,6-dinitrobenzoic acid and 2,6-dinitrobenzoic acid methyl ester 13 were prepared according to literature methods.…”

Section: General Proceduresmentioning

confidence: 99%

Cysteine‐Specific Blue Fluorescence Probe

Reddy

Chang

2006

J Chinese Chemical Soc

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A strong fluorescence probe has been designed to investigate cytochrome c folding kinetics. The cysteine specific modifier, 2-[(-Iodo-acetyl)-methyl-amino]-6-methylaminobenzoic acid methyl ester (1), has been prepared, and the reaction with cysteine can be performed in aqueous solution to ensure its application to protein modification. The model compound, 2-{[2-(2-Acetylamino-2-methyoxycarbonylethylsulfanyl)-acetyl]-methyl-amino}-6-methyl amino-benzoic acid methyl ester (2), resulting from the reaction of 1 with N-acetyl cysteine has emission quantum yields of 0.627 and 0.185 in nonaqueous and aqueous buffer solutions, respectively. The lifetime of 4.6 ns for compound 2 manifests a singlet excited-state. The Förster energy transfer distance of compound 2 and cytochrome c is calculated to be 45 Å.

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The Synthesis of 6-Formylsalicylic Acid, Esters of 6-Bromomethylsalicylic Acid, and Related Substances

Cited by 29 publications

References 9 publications

2-Acetoxy-6-methylbenzoic acid

2-Acetoxy-6-methylbenzoic acid

Bioconversion of Proposed Precursors into Theobroxide and Related Compounds

Cysteine‐Specific Blue Fluorescence Probe

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