The Synthesis of 2-(5-(Aryloxymethyl)-1,3,4-thiadiazol-2-ylthio)-N-arylacetamides at Room Temperature via Grinding

Abstract

Fifteen 2-(5-(aryloxymethyl)-1,3,4-thiadiazol-2-ylthio)-N-arylacetamides were efficiently synthesized from the reaction of 2-chloro-N-arylacetamide with 5-(aryloxymethyl)-1,3,4-thiadiazole-2-thiol under solvent-free conditions at room temperature via grinding. The key advantages of the method are the short reaction time, high yields, simple workup, and environmentally friendly conditions compared to conventional heating.

Alkylation of SH‐heterocycles with diethyl phosphite using tetrachloroethylene as an efficient solvent

“…Thin‐layer chromatography (TLC) was performed on 5 × 10 cm aluminum plates coated with silica gel 60F‐254, in an appropriate solvent. 1,3,4‐Thiadiazole‐2‐thiols and 1,3,4‐oxadiazole‐2‐thiols were synthesized by our group 18.…”