The synthesis of 131I-5-iodo-2-thiouracil with iodo-genTM

Bakker, C. N. M.; Kaspersen, Frans M.; Langevelde, A. van; Pauwels, E. K. J.

doi:10.1016/0020-708x(80)90316-6

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Iodine Monochloride1

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1982

2009

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Cited by 18 publications

(2 citation statements)

References 12 publications

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“…Iodogen is essentially insoluble in water76 and so can be used as a thin film coating the wall of the radioiodination vessel, thus permitting labeling with very little contact of the organic compound with the oxidizing agent.8,66 Iodogen has been used in the radioiodination of a series of uracils64 and a series of thiouracils. 81 In the latter case iodogen gave better results than chloramine T.…”

Section: Iodine Monochloridementioning

confidence: 93%

Radioiodination techniques for small organic molecules

Seevers¹,

Counsell²

1982

Chem. Rev.

278

147

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Section: Iodine Monochloridementioning

confidence: 93%

Radioiodination techniques for small organic molecules

Seevers¹,

Counsell²

1982

Chem. Rev.

278

147

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“…I23I-ITU was prepared and purified as described by Bakker et al [22], In all patients uptake tests of both l23I-labclcd thiouracil and 67Ga-citrate were per formed. Measurement of ocular l23I uptake was per formed 24 h after intravenous administration of 1 mCi l23I-labeled thiouracil.…”

Section: Methodsmentioning

confidence: 99%

Scintimetric Detection of Choroidal Malignant Melanoma with [<sup>123</sup>I]-5-Iodo-2-Thiouracil

Franken¹,

Delft²,

Langevelde³

et al. 1986

Ophthalmologica

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[¹²³I]-5-iodo-2-thiouracil (¹²³I-ITU) was evaluated as a radiopharmaceutical for tumor detection in 10 patients with proven choroidal melanoma. Uptake of ¹²³I-ITU was measured with a specially designed single eye probe collimator, 24 h after administration of ¹²³I-ITU. Increased uptake in the tumor-bearing eye as compared to the fellow nontumor bearing eye was found in 7 out of 10 cases when the probe was located 3.5 cm in front of the eye (p < 0.01). By using a double pinhole collimator tests were positive in 3 out of 10 ¹²³I-ITU studies only. Tests with ¹²³I-ITU were compared with 67Ga tests in the same patients. The 67Ga tests with the single eye probe collimator were positive in 6 out of 10 cases when the probe was located 6 cm in front of the eye. With the double pinhole collimator tests were positive in 7 out of 10 67Ga studies. It is concluded that ¹²³I-labeled thiouracil is at least as useful as a radiopharmaceutical for ocular melanoma diagnosis as 67Ga-citrate, provided measurements are performed with a single eye probe.

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Detection of Melanomas

Levine¹

1983

Arch Dermatol

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The synthesis of 131I-5-iodo-2-thiouracil with iodo-genTM

Cited by 18 publications

References 12 publications

Radioiodination techniques for small organic molecules

Radioiodination techniques for small organic molecules

Scintimetric Detection of Choroidal Malignant Melanoma with [<sup>123</sup>I]-5-Iodo-2-Thiouracil

Detection of Melanomas

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