The Synthesis of 1,4,7,10-Tetraazacyclododecanes with Acetylsalicylic Side Arm as Potential Cobalt(II) Fluorophores

Skwierawska, Anna; Paluszkiewicz, Ewa; Przyborowska, Monika; Ossowski, Tadeusz

doi:10.1023/b:jiph.0000031108.44843.92

Cited by 4 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct N ‐monoacylation of cyclen ( 1 ) with equimolar amount of acetylsalicylic acid chloride ( 52 ) in dichloromethane has been recently described 41. The reaction to form N ‐monoaroylated cyclen 53 proceeded in rather low yield (27 %) and extensive chromatographic purification of the product was required (Scheme ).…”

Section: Selective N‐monofunctionalization Of Cyclenmentioning

confidence: 99%

“…An interesting example of N ‐trifunctionalization of cyclen starting from N ‐monoacylcyclen 53 (see Scheme for preparation) has been described recently 41. Reaction of N ‐monoacylcyclen 53 with paraformaldehyde (3.3 equiv.)…”

Section: Selective N‐trifunctionalization Of Cyclenmentioning

confidence: 99%

“…and triethyl phosphite (4 equiv.) in warm (40 °C) THF was found to produce N ‐trifunctionalized cyclen 96 in 60 % yield (Scheme ) 41…”

Section: Selective N‐trifunctionalization Of Cyclenmentioning

confidence: 99%

See 2 more Smart Citations

Synthetic Strategies TowardN‐Functionalized Cyclens

Suchý

Hudson

2008

Eur J Org Chem

View full text Add to dashboard Cite

Cyclen (1,4,7,10‐tetraazadodecane) is a widely used building block in the synthesis of many important molecules with applications spanning MRI contrast agents, fluorescent probes and heavy metals sensors. This review describes the various synthetic methodologies employed for the preparation of N‐functionalized cyclens such as: synthesis from acyclic precursors; alkylation or acylation of cyclen; and protecting group manipulations. Emphasis is given to synthetic strategies allowing for the selective, differential N‐functionalization of cyclen which is particularly useful for many modern applications.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

show abstract

Section: Selective N‐monofunctionalization Of Cyclenmentioning

confidence: 99%

Section: Selective N‐trifunctionalization Of Cyclenmentioning

confidence: 99%