The synthesis, molecular structure and spectra properties of sulphur and selenium deferiprone analogues

Abstract

Deferiprone has a broad spectrum of biological effects. Thus it is interesting to investigate the influence of structural changes in deferiprone on its biological activity. This work presents a synthesis of a new selenium analogue of deferiprone, 3-hydroxy-1,2-dimethyl-4(1H)-pyridineselenone (3-HDPSe), and an improved method for synthesis of a sulfur analogue of deferiprone, 3-hydroxy-1,2-dimethyl-4(1H)-pyridinethione (3-HDPT). The structures of the synthesized compounds were confirmed by means of IR, MS, 1 H NMR and 13 C NMR measurements. Single crystals of the selenium analogue were obtained and the crystal structure determined using X-ray diffraction. Additionally DFT (the B3LYP functional combined with the 6-311++G** basis set) theoretical calculations were conducted and the results compared with experimental data.

IntroducingN-,P-, andS-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes

“…In order to determine if one candidate's unique set of properties is properly suited for the complex biological environment of a mammalian organism, in vivo tests should be carried out. 63 26 [Rh(Cp*)(MeIm) 2 Cl]Cl, 26 [Ir(Cp*)(MeIm) 2 Cl] Cl, 26 and ligands 2a, 67 and 2b 23 were prepared according to literature. The solvents used were purchased from commercial sources and dried before use if needed.…”