The synthesis, lipophilicity and cytotoxic effects of new ruthenium(II) arene complexes with chromone derivatives

Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest

“…The observed lipophilicity values are higher than those for the previously reported Ag(I), Au(I), Ru(II), Ga(III) and Pt(II) complexes. [46][47][48][49] DNA binding. Electronic absorption spectra of complexes (1-6) with varying amount of CT-DNA solution showed hypochromic effect in the intra-ligand (n-p*) region with a signicant red shi (4-6 nm), indicating the strong intercalative mode of binding of the complexes with DNA (Fig.…”

Iron(III) and nickel(II) complexes of tetradentate thiosemicarbazones: Synthesis, structure, cytotoxicity, and lipophilicity

“…Due to the low lipophilicity of effective iron complexes in our study, it would be more accurate independently to evaluate the cytotoxicity from lipophilicity for S‐alkyl‐thiosemicarbazidato‐metal complexes, as in some ruthenium complexes . When the antileukemic activity was evaluated independently of lipophilicity, these IC 50 values revealed that the anticancer chemicals with optimum activity could be obtained depending on the metal and substituents of these complex structures.…”

“…Some studies revealed that the high cytotoxicity of platinum complexes could be correlated with high lipophilicity . In contrast, the cytotoxicity of some ruthenium complexes of flavone or chromone derivatives against the melanoma cell lines is dependent on structure more than lipophilicity …”

“…Lipophilicity should be known for the design of pharmaceutical products because it provides for the prediction of drug effects such as the degree of release, transport, and absorption in the body . Log P values are also used in a structure‐activity relationship and quantitative structure‐activity relationship studies …”

Cytotoxic effect, generation of reactive oxygen/nitrogen species and electrochemical properties of Cu(ii) complexes in comparison to half-sandwich complexes of Ru(ii) with aminochromone derivatives

“…[16][17][18] The synthesis and X-ray structures of copper(II) and ruthenium(II) complexes with aminoavones as ligands and their interesting chemical and biological properties have been described in previous papers. 19,20 However the present paper examines the physicochemical properties of copper(II) and ruthenium(II) complexes with 6-aminoavone (3) and 6-aminochromone (4) by the synthesis of new complexes: 3a, 4a, 4b. Due to the potential anticancer activity, low toxicity and high selectivity of all obtained Cu(II) and Ru(II) complexes, their cytotoxicity was compared with that of reference agents like cisplatin, carboplatin, naringenin or quercetin.…”