The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanilino)-N-(3,4-dimethylphenyl)quinoline-3-carboxamide

Abstract

The structure of the title quinoline carboxamide derivative, C26H25N3O, is described. The quinoline moiety is not planar as a result of a slight puckering of the pyridine ring. The secondary amine has a slightly pyramidal geometry, certainly not planar. Both intra- and intermolecular hydrogen bonds are present. Hirshfeld surface analysis and lattice energies were used to investigate the intermolecular interactions.

New triazine bridged triads based on BODIPY-porphyrin systems: Extended absorption, efficient energy transfer and upconverted emission

“…The remaining missing and misplaced non-hydrogen atoms were located from difference Fourier maps calculated from successive full-matrix least-squares refinement cycles on F 2 using SHELXL from the 2018/3 release [58]. All structural refinements were performed using the graphical interface ShelXle [59].…”

Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?

“…Then, carboxylic acids ( 18 or 19 ) reacted with the appropriate arylamine, using 2-(1 H -benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate (TBTU) as a coupling agent (Scheme D, step b) . In this case, the use of POCl 3 was not suitable for the synthesis of these amides due to the formation of several byproducts. , …”

“…16 In this case, the use of POCl 3 was not suitable for the synthesis of these amides due to the formation of several byproducts. 17,18 Thiochromone derivatives (30 and 31) were obtained using the synthetic strategy shown in Scheme 1E. The synthesis started with the reaction of ethyl 3-(2-fluorophenyl)-3oxopropanoate (26) with N,N-dimethylformamide dimethyl acetal affording the intermediate 27 (Scheme 1E, step a), which in turn was reacted with hydrogen sulfide (H 2 S) to yield a thiochromone ester (28, Scheme 1E, step b).…”