The synthesis and structural characterization of novel N-meta-ferrocenyl benzoyl dipeptide esters

The synthesis and structural characterization of novel N-meta-ferrocenyl benzoyl dipeptide esters: The X-ray crystal structure and in vitro anti-cancer activity of N-{meta-ferrocenyl)benzoyl}-l-alanine-glycine ethyl ester

“…In our laboratory, we have synthesized various ferrocene derivatives incorporating natural amino acids and dipeptides [16][17][18][19][20][21][22]. We have incorporated three key moieties in the synthesis of these unusual biological materials, namely: (i) an electroactive core, (ii) a conjugated linker that lowers the oxidation potential of the ferrocene moiety, and (iii) an amino acid or peptide derivative that can interact with other molecules via hydrogen bonding.…”

Synthesis and characterization of novel N-para-ferrocenyl benzoyl dipeptide esters

“…All the proton and carbon chemical shifts for compounds 2-5 were unambiguously assigned by a combination of DEPT-135 and 1 H-13 C-COSY (HMQC). The 1 H and 13 C NMR spectra for compounds 2-5 showed peaks in the ferrocene region characteristic of a ferrocenyl benzoyl moiety[32][33][34][35][36]. The protons in the ortho position of the (g5 -C 5 H 4 ) ring appear in the region d 4.61 to d 4.64 whereas the protons in the meta position occur in the range d 4.3 to d 4.32.…”

“…We recently reported the synthesis and structural characterization of a series of N-para, N-meta, and N-ortho-ferrocenyl benzoyl amino acid and N-meta-ferrocenyl benzoyl dipeptide ester derivatives. [32][33][34][35][36].…”

Preparation and characterization of α-fluorinated-γ-aminophosphonates

“…The aminophosphonates 4a-e also were converted into their dipeptide analogues 6a-e in reaction with N-tert-butoxycarbonyl-L-phenylalanine in presence of N-hydroxybenzotriazole (HOBt) and N,N 0 -dicyclohexylcarbodiimide (DCC) as coupling reagents (Scheme 3) [22]. The above mentioned synthesis of compounds 6a-e is an example how to incorporate fluorinated aminophosphonate moieties into peptide chain.…”