The synthesis and screening of the antimicrobial activity of some novel 3-(furan-2-yl)-1-(aryl)-3-(phenylthio) propan-1-one derivatives

Abstract

A series of thiophenol adducts (3a-m) were prepared by addition of thiophenol to chalcones (1a-m) in the presence of a catalytic amount of KOt-Bu in solvent free conditions. In addition, the antibacterial and antifungal in vitro properties were tested against some human pathogenic microorganisms by employing the disk diffusion technique. A majority of compounds were remarkably active against several of the microorganisms. Compound 3i was determined to be the most active compound.

N-(4-Acetylphenyl)-N′-(4-fluorophenyl)urea

“…Acetophenones having different substituents in synthetic organic chemistry are used as an important building block (Bing-Wei, 2010). In particular, they are frequently used in conjunction with aldehydes in the synthesis of chalcone derivatives (Kocyigit et al, 2018;Karaman et al, 2010;Ceylan et al, 2011), which are used as starting materials in the preparation of useful and multifunctional heterocyclic and bioactive compounds (Gü rdere, Gü mü ş et al, 2017; Gü rdere, Kamo et al, 2017;Gezegen et al, 2013). In this article we report the crystal structure of 4-fluorophenylurea-substituted acetophenone, namely N-(4-acetylphenyl)-N 0 -(4-fluorophenyl)urea.…”

Iodine-Catalyzed Addition of Thiophenol to Isoindolsubstitue Chalcones

“…Elemental analizler LECO CHNS 932 Elemental Analyzer'dan elde edildi. Çıkış bileşikleri 1, 2a-j ve 3a-j bilinen yöntemler [34,36] kullanılarak sentezlendi.…”

Synthesis and anti-bacterial activity of novel 1,3-pheylene-bis-N-acetyl- and N-phenylpyrazole derivatives

“…Antibacterial activities were determined by disc-diffusion method 28,29 using 100 µL of suspension containing 10 8 CFU/mL of bacteria and 10 6 CFU/mL of yeast spread on Nutrient Agar (NA) and Sabouraud Dextrose Agar (SDA) medium, respectively. Starting dilution (1/10 mg/ml) was prepared by dissolving each of the compounds in DMSO.…”