The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole

Abstract

Abstract:Two novel indazole derivatives protected with p-methoxybenzyl group were synthesized and characterized. The crystal and molecular structure of 2-(4-methoxybenzyl)-4-nitro-2H-indazole as one out of the two regioisomers is reported. The compound was obtained from a saturated petroleum ether/ethyl acetate mixture and crystallizes in the triclinic space group P1. The unit cell parameters are: a = 6.8994 (1) . There are two independent molecules found in the asymmetric unit.

Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands and potential PET radiotracers

“…In case of the introduction of both the PMB and the methyl group, the respective 2H-regioisomer was obtained supplementary. 30 No 2H-regioisomer was found when applying the EOE group.…”