The synthesis and investigation of impurities found in clandestine laboratories: Baeyer-Villiger route part II; synthesis of Phenyl-2-propanone (P2P) analogues from substituted benzaldehydes

Origins of N-formylmethamphetamine and N-acetylmethamphetamine in methamphetamine produced by the hydriodic acid and red phosphorus reduction of pseudoephedrine

“…The use of gas chromatography-mass spectrometry (GC-MS) for the generation of profiles of synthesis by-products, adulterants, impurities and unchanged precursors in illicit drugs is a wellestablished means of gathering tactical and strategic intelligence relevant to illicit drug distribution and manufacture [1,2,3,4,5,6,7,8,9]. Methamphetamine (MA) is an illicit drug of major importance in many countries around the world, and as a consequence a substantial effort has gone into the development of methods to profileMA seizures.…”

Interpol Review of Drug Analysis 2019-2022

“…2021 synthesis and investigation of impurities found in clandestine laboratories from synthesis of Phenyl-2-propanone (P2P) analogues from substituted benzaldehydes [ 244 ]; investigation of the formation of P2P degradation products during long-term storage and the factors that affected P2P degradation [ 245 ]; 2022 analysis of phenylacetone precursors (ethyl 3-oxo-2-phenylbutyrate, methyl 3-oxo-4-phenylbutyrate, and ethyl 3-oxo-4-phenylbutyrate) by GC-MS and their conversion to P2P to identify and elucidate the synthesis method of P2P [ 246 ].…”

Profiling of synthesis‐related impurities of the synthetic cannabinoid Cumyl‐5F‐PINACA in seized samples of e‐liquids via multivariate analysis of UHPLC−MSn data

“…It can be used to link seizures, identify trafficking and synthesis routes, or provide information on precursor materials and their origin . The manufacturing route of a drug is considered to have a major influence on the chemical profile of samples, producing a distinct set of by‐products or impurities depending on the used educts, coupling reagents, catalysts or overall reaction conditions . Several methodologies of the analysis of organic impurities or by‐products were developed for classic drugs like cocaine, heroin, and amphetamine .…”