The synthesis and investigation of different cobaloximines by spectroscopic methods

Kılıç, Ahmet; Durgun, Mustafa; Yorulmaz, Nuri; Yavuz, Rahime

doi:10.1016/j.molstruc.2018.03.121

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…In the presence of catalytic AcOH, nootkatone reacted with different hydrazides to obtain acylhydrazone derivatives N1 – N7 [34] . Then, in the presence of NaHCO 3 , nootkatone and NH 2 OH⋅HCl were refluxed at 85 °C with EtOH as the reaction solvent to obtain the oxime derivative N3 [35] . In the last, oximide derivatives N8 – N53 were prepared by the reaction of intermediate N3 with different acids and acyl chloride [36] …”

Section: Resultsmentioning

confidence: 99%

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Design, Synthesis and Antifungal Activity of Nootkatone Derivatives Containing Acylhydrazone and Oxime Ester

Liang,

Gao,

Jian

et al. 2024

Chemistry & Biodiversity

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In an attempt to search for new natural products‐based antifungal agents, fifty‐three nootkatone derivatives were designed, synthesized, and evaluated for their antifungal activity against Phytophthora parasitica var nicotianae, Fusarium oxysporum, Fusarium graminearum and Phomopsis sp. by the mycelium growth rate method. Nootkatone derivatives N17 exhibited good inhibitory activity against Phomopsis. sp. with EC50 values of 2.02 μM. The control effect of N17 against Phomopsis. sp. on kiwifruit showed that N17 exhibited a good curative effect in reducing kiwifruit rot at the concentration of 202 μM(100 × EC50 ), with the curative effect of 41.11% , which was better than commercial control of pyrimethanil at the concentration of 13437 μM(100 × EC50 ) with the curative effect of 38.65%. Phomopsis. sp. mycelium treated with N17 showed irregular surface collapse and shrinkage, and the cell membrane crinkled irregularly, vacuoles expanded significantly, mitochondria contracted, and organelles partially swollen by the SEM and TEM detected. Preliminary pharmacological experiments show that N17 exerted antifungal effects by altering release of cellular contents, and altering cell membrane permeability and integrity. The presented results implied that N17 may be as a potential antifungal agents for developing more efficient fungicides to control Phomopsis sp..

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Section: Resultsmentioning

confidence: 99%

“…[34] Then, in the presence of NaHCO 3 , nootkatone and NH 2 OH•HCl were refluxed at 85 °C with EtOH as the reaction solvent to obtain the oxime derivative N3. [35] In the last, oximide derivatives N8-N53 were prepared by the reaction of intermediate N3 with different acids and acyl chloride. [36] Figure 3.…”

Section: Synthesis Of Target Compounds N1-n53mentioning

confidence: 99%

Design, Synthesis and Antifungal Activity of Nootkatone Derivatives Containing Acylhydrazone and Oxime Ester

Liang,

Gao,

Jian

et al. 2024

Chemistry & Biodiversity

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“…Monoxime was prepared as described in our previous study by making some modifications. [19] First, the temperature of the cryostat was adjusted to < À 5 °C, and 8.4 g of sodium metal was dissolved in ethanol (200 mL) at À 5 °C, then n-butyl nitrite (12.7 g, 0.123 mol) was added drop by drop for 30 min to the solution. After this process, (25 g, 0.123 mol) of 4'piperidinoacetophenone was taken and added gradually with a spatula within 40-50 min.…”

Section: Synthesis Synthesis Of Monoximementioning

confidence: 99%

“…In this study, monoxime and vic-dioxime ligand (LH 2 ) (1) were obtained according to the method specified in the literature. [19,20] Synthesis of the target compound (1) was achieved using 1 : 1 molar ratios (Scheme 1). The monoxime and vic-dioxime ligand (1) were characterized by NMR ( 1 H and 13 C), LC/MS/MS spectrometer, FT-IR and UV/VIS spectra, elemental analysis, and melting point.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Preparation of Cu(II), Ni(II), Ti(IV), VO(IV), and Zn(II) Metal Complexes Derived from Novel vic‐Dioxime and Investigation of Their Antioxidant and Antibacterial Activities

Alhafez

Savcı

Alan

et al. 2022

Chemistry & Biodiversity

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In this work, novel vic-dioxime ligand (LH 2 ) containing bound to the N 4 -oxime core moiety and its complexes with Cu(II), Ni(II), Ti(IV), VO(IV), and Zn(II) salts have been studied. The structure of the ligand and its complexes were successfully synthesized and characterized using NMR ( 1 H and 13 C), LC/MS/MS spectrometer, FT-IR and UV/ VIS spectroscopy, melting point, and magnetic susceptibility measurements. Vic-dioxime ligand (LH 2 ) (1) and its metal complexes ([Cu(LH) 5), and [Zn(LH) 2 ] (6), respectively) were tested for them in-vitro antibacterial and antioxidant activities. According to the metal chelating results of the study, it was determined that compounds (1), ( 2), ( 3), and ( 6) showed very good activity, and especially compound (2), had a stronger metal chelating capacity due to ligand dissociation from the synthesized metal complexes, which then would chelate Fe(II) in the experimental setting. When microorganisms were evaluated in terms of the % viability effect, it was observed that all compounds had activity against C. Albicans and S. Cerevisiae at rates similar to antibiotics.

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“…Several recent papers have presented various topics, including synthetic pathways leading to oxime complexes and structural and different coordination modes (Figure 2). The binding mode of the oxime function depends not only on the coordinative ability of the oxime group but also on the presence of atom donors in the same molecule [6][7][8][9]. For example, imidazole oximes present several donor atoms in their structures.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and structural study of new nickel(II) and mercury (II) complexes with imidazole oxime ligand

Bouchouit

BELAHLOU

Guergouri

et al. 2023

Journal of Molecular Structure

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The synthesis and investigation of different cobaloximines by spectroscopic methods

Cited by 11 publications

References 32 publications

Design, Synthesis and Antifungal Activity of Nootkatone Derivatives Containing Acylhydrazone and Oxime Ester

Design, Synthesis and Antifungal Activity of Nootkatone Derivatives Containing Acylhydrazone and Oxime Ester

Preparation of Cu(II), Ni(II), Ti(IV), VO(IV), and Zn(II) Metal Complexes Derived from Novel vic‐Dioxime and Investigation of Their Antioxidant and Antibacterial Activities

Synthesis, characterization and structural study of new nickel(II) and mercury (II) complexes with imidazole oxime ligand

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