The synthesis and characterization of poly(ethylene glycol) grafted on pullulan

Jiao, Yonghua; Fu, Yu; Jiang, Zhenhua

doi:10.1002/app.13238

Cited by 17 publications

(7 citation statements)

References 19 publications

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“…This indicated that the esterification of PUL was formed by the presence of the Pluronic. This is consistent with the results published by Jiao et al ., who revealed that a new peak appeared, indicating esterified PUL between the carboxyl acid groups of PEG and the hydroxyl groups of PUL . Furthermore, our result is consistent with data from Chen et al ., which indicated a modification of an ester carbonyl of PUL with stearic acid .…”

Section: Resultssupporting

confidence: 93%

Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Lee

Chen

et al. 2017

J of Applied Polymer Sci

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In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability.

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Section: Resultssupporting

confidence: 93%

Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Lee

Chen

et al. 2017

J of Applied Polymer Sci

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“…A number of papers have been published on the grafting polymerization of N-isopropylacrylamide (Masci, Bontempo, & Crescenzi, 2002), etylenic compound (Seizo, Kozo, Nobuhiro, & Fumio, 1975), lactide (Ohya, Maruhashi, & Ouchi, 1998), ethylene glycol (Jiao, Fu, & Jiang, 2004), butyl acrylate (Tian, Gao, Yu, & Duan, 1992), p-hydroxystyrene (Chen, Oshima, & Kumanotani, 1985), methyl methacrylate (Wu, Jin, Kim, Tong, & Chen, 2009) onto pullulan.…”

Section: Introductionmentioning

confidence: 99%

Studies on graft copolymerization of 3-acrylamidopropyl trimethylammonium chloride on pullulan

Constantin¹,

Mihalcea²,

Oanea³

et al. 2011

Carbohydrate Polymers

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“…It is a linear polysaccharide harboring maltotriosyl repeating units united by α‐(1→6)‐linkages or chains of D ‐glucopyranosyl units that regularly alternate between one α‐(1→6)‐ D and two α‐(1→4)‐ D linkages 13, 14. Pullulan has some limitations in processing as a consequence of its melting temperature and, thus, we conducted acylation with acetic anhydride and L ‐lactide in an effort to improve its properties 13, 15–17…”

Section: Introductionmentioning

confidence: 99%

Self‐organized nanogels from pullulan‐g‐poly(L‐lactide) synthesized by one‐pot method: Physicochemical characterization and in vitro doxorubicin release

Cho

Park

2009

J of Applied Polymer Sci

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Water-insoluble pullulan-g-poly(L-lactide) (PUPL) was successfully synthesized via a one-pot method in the presence of triethylamine in dimethyl sulfoxide, in an effort to design a novel anticancer agent carrier. Three samples (designated as PUPL 1, 2, and 3) were obtained, which differed in the moles of lactides grafted to the pullulan. The degrees of grafted lactide per 1 glucose unit in pullulan were 0.68, 0.60, and 0.45 for PUPL 1, 2, and 3, respectively. These copolymers were dissolved in several organic solvents, including dimethyl sulfoxide, acetone, and ethanol, but were insoluble in water. The self-organized nanogels were then prepared from the polymers via dialysis. To study the organizing behavior of the polymers, their critical association concentrations were measured. Their values were 5.0, 15.9, and 52.9 mg/L for PUPL 1, 2, and 3, respectively. The results showed that lactide in the polymers could function as a hydrophobic moiety for the formation of selforganized nanogels. To estimate the potential of PUPL 1 as an anticancer drug carrier, we used doxorubicin (DOX) as a model drug. The DOX loading efficiencies of PUPL 1 were more than 52%, which differed with differing initial DOX concentrations. High loading resulted in slower DOX release as the result of increases in hydrophobic interaction.In conclusion, PUPL nanogels may prove useful as anticancer drug carriers because of their low critical association concentrations and the controlled DOX release rate V

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The synthesis and characterization of poly(ethylene glycol) grafted on pullulan

Cited by 17 publications

References 19 publications

Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Studies on graft copolymerization of 3-acrylamidopropyl trimethylammonium chloride on pullulan

Self‐organized nanogels from pullulan‐g‐poly(L‐lactide) synthesized by one‐pot method: Physicochemical characterization and in vitro doxorubicin release

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