The synthesis and characterization of a series of cobalt(II) β-ketoaminato complexes and their cytotoxic activity towards human tumor cell lines

Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

“…Klegeris and co-workers prepared a series of square-planar Co(II) complexes of β-ketoaminato ligands, which increase the activation of caspase-3 and induce apoptosis in prostate cancer cells. 9 Pombeiro and co-workers showed that a series of Co(II) tris(pyrazolyl)methane (“scorpionate”) complexes induced apoptosis in colorectal and liver cancer cells, with the generation of oxygen-centered radicals proposed as the mechanism of action based on their observed ability to cleave plasmid DNA. 10 Chiniforoshan and co-workers showed that Co(II), Ni(II), and Cu(II) complexes of phenanthroline and the conjugate base of the natural product juglone induced early-phase apoptosis in liver, cervical, and colorectal cancer cells, likely involving intercalation with DNA.…”

Evaluation of the anticancer activities with various ligand substituents in Co(ii/iii)-picolyl phenolate derivatives: synthesis, characterization, DFT, DNA cleavage, and molecular docking studies

“…The present study also reveals the same observation that the sterically hindered complexes (2 and 3) show higher cleavage activity. 61,63,64 The DNA cleavage activity is observed for 1, 2, and 3 in both reducing and oxidizing conditions. Complexes 1, 2, and 3 show 29, 18, and 24% DNA cleavage, respectively, in the presence of GSH, whereas 35, 26, and 32% DNA cleavage activity, respectively, is shown in H 2 O 2 .…”

“…In literature, many cobalt(II) complexes with nitrogen donors promote the cleavage of DNA in the presence of both oxidizing and reducing environments through singlet oxygen generation. 60,61,63,64 2.4.8. Confirmation of generation of singlet oxygen species.…”

Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment

“…Gurley et al reported that there are only a few studies describing Co-based metallodrugs with potential therapeutic applications [39]. For instance, Ott et al informed the preparation and antitumor efficacy of [2-acetoxy-(2-propynyl)benzoate] hexacarbonyldicobalt [40].…”