The synthesis and characterization of a novel biodegradable and electroactive polyphosphazene for nerve regeneration

Zhang, Qingsong; Yan, Yunfei; Li, Shipu; Tao, Feng

doi:10.1016/j.msec.2009.09.013

Cited by 98 publications

(44 citation statements)

References 35 publications

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“…Polyaniline and aniline oligomers have been demonstrated to enhance the proliferation ability of the electrical stimuli sensitive cells, such as mesenchymal stem cells, [49][50] C2C12 myoblast, 50-52 neuronal cells [53][54] and H9c2 myocardial cells. [55][56] The CS-AT hydrogels exhibited a good electroactivity and conductivity, which will 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 25 have a good effect on the proliferation of the cells.…”

Section: Cell Proliferation In Cs-at Hydrogelmentioning

confidence: 99%

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Dong

Zhao

Guo

et al. 2016

ACS Appl. Mater. Interfaces

471

324

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Cell therapy is a promising strategy to regenerate cardiac tissue for myocardial infarction. Injectable hydrogels with conductivity and self-healing ability are highly desirable as cell delivery vehicles for cardiac regeneration. Here, we developed self-healable conductive injectable hydrogels based on chitosan-graft-aniline tetramer (CS-AT) and dibenzaldehyde-terminated poly(ethylene glycol) (PEG-DA) as cell delivery vehicles for myocardial infarction. Self-healed electroactive hydrogels were obtained after mixing CS-AT and PEG-DA solutions at physiological conditions. Rapid self-healing behavior was investigated by rheometer. Swelling behavior, morphology, mechanical strength, electrochemistry, conductivity, adhesiveness to host tissue and antibacterial property of the injectable hydrogels were fully studied. Conductivity of the hydrogels is ∼10(-3) S·cm(-1), which is quite close to native cardiac tissue. Proliferation of C2C12 myoblasts in the hydrogel showed its good biocompatibility. After injection, viability of C2C12 cells in the hydrogels showed no significant difference with that before injection. Two different cell types were successfully encapsulated in the hydrogels by self-healing effect. Cell delivery profile of C2C12 myoblasts and H9c2 cardiac cells showed a tunable release rate, and in vivo cell retention in the conductive hydrogels was also studied. Subcutaneous injection and in vivo degradation of the hydrogels demonstrated their injectability and biodegradability. Together, these self-healing conductive biodegradable injectable hydrogels are excellent candidates as cell delivery vehicle for cardiac repair.

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Section: Cell Proliferation In Cs-at Hydrogelmentioning

confidence: 99%

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Dong

Zhao

Guo

et al. 2016

ACS Appl. Mater. Interfaces

471

324

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“…A novel block copolymer of polyglycolide and aniline pentamer that is electro-active and degradable was also synthesized by Ding and co-workers (2007). Zhang et al (2010) synthesized a novel, electricallyconductive and biodegradable polyphosphazene polymer containing aniline pentamer with glycine ethyl ester as side chains and evaluated its biocompatibility using Schwann cells. Their results showed that the polymer exhibited no cytotoxicity, indicating suitability of this polymer as a scaffold material for peripheral nerve regeneration or other biomedical devices that require electroactivity.…”

Section: Conducting Polymersmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

603

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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“…The PEIP nerve guides appeared to be more biocompatible than silicone tubes that are currently used, as significantly less scar tissue was induced and a thinner fibrotic capsule formed around these guides. Zhang et al[106] have synthesized a novel electrically-conductive and biodegradable polyphosphazene polymer containing parent aniline pentamer (PAP) and glycine ethyl ester (GEE) as side chains for use in nerve tissue engineering. Conductivity is needed in nerve tissue engineering considering that neural signals are propagated along nerve cells via electrical charges and therefore the polymers that are used to regenerate these tissues must be capable of transmitting waves of electricity.…”

Section: Applications Of Biodegradable Polyphosphazene and Its Blendsmentioning

confidence: 99%

Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering

Ogueri

Ivirico

Nair

et al. 2017

Regen. Eng. Transl. Med.

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The occurrence of musculoskeletal tissue injury or disease and the subsequent functional impairment is at an alarming rate. It continues to be one of the most challenging problems in the human health care. Regenerative engineering offers a promising transdisciplinary strategy for tissues regeneration based on the convergence of tissue engineering, advanced materials science, stem cell science, developmental biology and clinical translation. Biomaterials are emerging as extracellular-mimicking matrices designed to provide instructive cues to control cell behavior and ultimately, be applied as therapies to regenerate damaged tissues. Biodegradable polymers constitute an attractive class of biomaterials for the development of scaffolds due to their flexibility in chemistry and the ability to be excreted or resorbed by the body. Herein, the focus will be on biodegradable polyphosphazene-based blend systems. The synthetic flexibility of polyphosphazene, combined with the unique inorganic backbone, has provided a springboard for more research and subsequent development of numerous novel materials that are capable of forming miscible blends with poly (lactide-co-glycolide) (PLAGA). Laurencin and co-workers has demonstrated the exploitation of the synthetic flexibility of Polyphosphazene that will allow the design of novel polymers, which can form miscible blends with PLAGA for biomedical applications. These novel blends, due to their well-tuned biodegradability, and mechanical and biological properties coupled with the buffering capacity of the degradation products, constitute ideal materials for regeneration of various musculoskeletal tissues. Lay Summary Regenerative engineering aims to regenerate complex tissues to address the clinical challenge of organ damage. Tissue engineering has largely focused on the restoration and repair of individual tissues and organs, but over the past 25 years, scientific, engineering, and medical advances have led to the introduction of this new approach which involves the regeneration of complex tissues and biological systems such as a knee or a whole limb. While a number of excellent advanced biomaterials have been developed, the choice of biomaterials, however, has increased over the past years to include polymers that can be designed with a range of mechanical properties, degradation rates, and chemical functionality. The polyphosphazenes are one good example. Their chemical versatility and hydrogen bonding capability encourages blending with other biologically relevant polymers. The further development of Polyphosphazene-based blends will present a wide spectrum of advanced biomaterials that can be used as scaffolds for regenerative engineering and as well as other biomedical applications.

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The synthesis and characterization of a novel biodegradable and electroactive polyphosphazene for nerve regeneration

Cited by 98 publications

References 35 publications

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Biodegradable Polyphosphazene-Based Blends for Regenerative Engineering

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