The synergistic impact of nonalcoholic fatty liver disease and metabolic syndrome on subclinical atherosclerosis

Hong, Ho Cheol; Hwang, Soon Young; Ryu, Jee-Youl; Yoo, Hye Jin; Seo, Jae Hyun; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook

doi:10.1111/cen.12940

Cited by 23 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 There appears to be a synergistic relationship between metabolic syndrome, nonalcoholic fatty liver disease, and prevalence of CAC, 101,102 as well as a synergistic relationship with smoking. 103 Furthermore, the progression of CAC was greater in people with metabolic syndrome and DM than in those without, and progression of CAC predicted future CVD event risk both in those with metabolic syndrome and in those with DM.…”

Section: Metabolic Syndromementioning

confidence: 99%

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin¹,

Blaha²,

Chiuve³

et al. 2017

Circulation

7,578

5,040

View full text Add to dashboard Cite

Section: Metabolic Syndromementioning

confidence: 99%

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin¹,

Blaha²,

Chiuve³

et al. 2017

Circulation

7,578

5,040

View full text Add to dashboard Cite

“…Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are also associated with endothelial dysfunction [ 57 ], whereas increasing age, liver fat, and triglyceride are all related to increased aortic stiffness in adults [ 58 ] and a recent study indicates that NAFLD and MS have a synergistic impact on the subclinical atherosclerosis [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

Tuttolomondo

Petta

Casuccio

et al. 2018

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundNo study evaluated vascular health markers in subjects with non-alcoholic fatty liver disease (NAFLD) through a combined analysis of reactive hyperemia peripheral arterial tonometry (RH-PAT) and arterial stiffness indexes.Aim of the studyWe aimed to assess whether NAFLD and its histological severity are associated with impairment of arterial stiffness and RH-PAT indexes in a mixed cohort of patients with biopsy-proven NAFLD.Materials and methodsThe Kleiner classification was used to grade NAFLD grade. Pulse wave velocity (PWV) and augmentation index (Aix) were used as markers of arterial stiffness, whereas endothelial function was assessed using reactive hyperemia index (RHI). The mini-mental state examination (MMSE) was administered to test cognitive performance.Results80 consecutive patients with biopsy-proven NAFLD and 83 controls without fatty liver disease. NAFLD subjects showed significantly lower mean RHI, higher mean arterial stiffness indexes and lower mean MMSE score. Multivariable analysis after correction for BMI, dyslipidaemia, hypertension, sex, diabetes, age and cardiovascular disease showed that BMI, diastolic blood pressure and RHI are significantly associated to NAFLD. Simple linear regression analysis showed among non-alcoholic steatohepatitis (NASH) subjects a significant negative relationship between ballooning grade and MMSE and a significant positive association between Kleiner steatosis grade and augmentation index.ConclusionsFuture research will be addressed to evaluate the relationship between inflammatory markers and arterial stiffness and endothelial function indexes in NAFLD subjects. These study will evaluate association between cardiovascular event incidence and arterial stiffness, endothelial and cognitive markers, and they will address the beneficial effects of cardiovascular drugs such as statins and ACE inhibitors on these surrogate markers in NAFLD subjects.

show abstract

“…Thus, NAFLD is not a simple component of MetS. In addition, the synthetic effect of NAFLD and MetS has been found in various diseases [ 51 , 52 ]. Therefore, we aimed to evaluate the interactive effect of SNAFLD and Mets on osteoporosis in postmenopausal females.…”

Section: Discussionmentioning

confidence: 99%

The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China

Chen

et al. 2018

International Journal of Endocrinology

View full text Add to dashboard Cite

The present study evaluated the potential combined effects of NAFLD and MetS on the development of osteoporosis. The relationship between NAFLD and MetS and osteoporosis was assessed in 938 postmenopausal female participants. Moderate and severe NAFLDs were combined as significant NAFLD (SNAFLD). All the subjects were divided into 4 subgroups based on the status of SNAFLD and MetS. Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction, and synergy index (SI) were used to investigate the additive interaction of those two factors. NAFLD, SNAFLD, and MetS were independent factors for osteoporosis with the adjustment of age and other confounders. The incidence of osteoporosis in MetS (+) SNAFLD (+) group was significantly higher than that in other three groups. RERI was 2.556 (95% CI = 0.475–4.636), AP was 0.454 (95% CI = 0.201–0.706), and SI was 2.231 (95% CI = 1.124 to 4.428), indicating the significant combined interaction of SNAFLD and MetS on the development of osteoporosis. SNAFLD and MetS are independent risk factors for osteoporosis in postmenopausal females, respectively. Moreover, SNAFLD and MetS have an additive effect on the development of osteoporosis.

show abstract

The synergistic impact of nonalcoholic fatty liver disease and metabolic syndrome on subclinical atherosclerosis

Abstract: The results show that NAFLD and MetS have a synergistic impact on the subclinical atherosclerosis, which suggests that individuals with both NAFLD and MetS should be strongly advised to engage in CVD prevention strategies.

Cited by 23 publications

References 39 publications

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China

Contact Info

Product

Resources

About