The synergistic effect of ultrasound and chemical penetration enhancers on chorioamnion mass transport

Azagury, Aharon; Khoury, Luai R.; Adato, Yair; Wolloch, Lior; Ariel, Ilana; Hallak, Mordechai; Kost, Joseph

doi:10.1016/j.jconrel.2014.12.025

Cited by 8 publications

(1 citation statement)

References 27 publications

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“…Intuitively, one would expect smaller NPs to penetrate more as was observed for various trans-membrane/tissue such as transdermal, [48] trans-tympanic, [49] transbuccal, [50] trans-chorioamnion, [51] and transnasal. [52] However, like our results, a study by Lai et al [17] found that 100 nm NPs were slower to diffuse in mucous compared to bigger NPs.…”

Section: Effects Of Particles Size and Small Intestine Region On Gi U...mentioning

confidence: 99%

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Azagury

Baptista

Milovanovic

et al. 2022

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Decades of research into the topic of oral nanoparticle (NP) delivery has still not provided a clear consensus regarding which properties produce an effective oral drug delivery system. The surface properties—charge and bioadhesiveness—as well as in vitro and in vivo correlation seem to generate the greatest number of disagreements within the field. Herein, a mechanism underlying the in vivo behavior of NPs is proposed, which bridges the gaps between these disagreements. The mechanism relies on the idea of biocoating—the coating of NPs with mucus—which alters their surface properties, and ultimately their systemic uptake. Utilizing this mechanism, several coated NPs are tested in vitro, ex vivo, and in vivo, and biocoating is found to affect NPs size, zeta‐potential, mucosal diffusion coefficient, the extent of aggregation, and in vivo/in vitro/ex vivo correlation. Based on these results, low molecular weight polylactic acid exhibits a 21‐fold increase in mucosal diffusion coefficient after precoating as compared to uncoated particles, as well as 20% less aggregation, and about 30% uptake to the blood in vivo. These discoveries suggest that biocoating reduces negative NP charge which results in an enhanced mucosal diffusion rate, increased gastrointestinal retention time, and high systemic uptake.

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Section: Effects Of Particles Size and Small Intestine Region On Gi U...mentioning

confidence: 99%

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Azagury

Baptista

Milovanovic

et al. 2022

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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The synergistic effect of ultrasound and chemical penetration enhancers on chorioamnion mass transport

Cited by 8 publications

References 27 publications

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Biocoating—A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles

Drug Delivery Systems

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

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