The Synergistic Antioxidant Effect and Antimicrobial Efficacity of Propolis, Myrrh and Chlorhexidine as Beneficial Toothpaste Components

Lisa, Elena Lacramioara; Cârâc, Geta; Barbu, Vasilica; Robu, Silvia

doi:10.37358/rc.17.9.5822

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…Myrrh as a traditional medicine has been used since ancient times. In modern times, myrrh is used as an antiseptic in topical and toothpaste [27]. It has been shown that some sesquiterpene components of myrrh, including furanodien-6-one, methoxyfuranoguai-9-en-8-one possess in vitro bactericidal, and fungicidal activity against multiple pathogenic bacteria, including E. coli , S. aureus , P. aeruginosa , and C. albicans [28], but these two most active compounds were not detected in our samples [19] (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi

et al. 2018

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Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2–4 weeks antibiotic treatment, about 10–20% of patients continue to suffer from persisting symptoms. While the cause of this condition is unclear, persistent infection was proposed as one possibility. It has recently been shown that B. burgdorferi develops dormant persisters in stationary phase cultures that are not killed by the current Lyme antibiotics, and there is interest in identifying novel drug candidates that more effectively kill such forms. We previously identified some highly active essential oils with excellent activity against biofilm and stationary phase B. burgdorferi. Here, we screened another 35 essential oils and found 10 essential oils (Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Cuminum cyminum L. seeds, Cymbopogon martini var. motia Bruno grass, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers, Amyris balsamifera L. wood, Thymus vulgaris L. leaves, Litsea cubeba (Lour.) Pers. fruits, Eucalyptus citriodora Hook. leaves) and the active component of cinnamon bark cinnamaldehyde (CA) at a low concentration of 0.1% have strong activity against stationary phase B. burgdorferi. At a lower concentration of 0.05%, essential oils of Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Cymbopogon martini var. motia Bruno grass and CA still exhibited strong activity against the stationary phase B. burgdorferi. CA also showed strong activity against replicating B. burgdorferi, with a MIC of 0.02% (or 0.2 μg/mL). In subculture studies, the top five essential oil hits Allium sativum L. bulbs, Pimenta officinalis Lindl. berries, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers, and Litsea cubeba (Lour.) Pers. fruits completely eradicated all B. burgdorferi stationary phase cells at 0.1%, while Cymbopogon martini var. motia Bruno grass, Eucalyptus citriodora Hook. leaves, Amyris balsamifera L. wood, Cuminum cyminum L. seeds, and Thymus vulgaris L. leaves failed to do so as shown by visible spirochetal growth after 21-day subculture. At concentration of 0.05%, only Allium sativum L. bulbs essential oil and CA sterilized the B. burgdorferi stationary phase culture, as shown by no regrowth during subculture, while Pimenta officinalis Lindl. berries, Commiphora myrrha (T. Nees) Engl. resin, Hedychium spicatum Buch.-Ham. ex Sm. flowers and Litsea cubeba (Lour.) Pers. fruits essential oils all had visible growth during subculture. Future studies are needed to determine if these highly active essential oils could eradicate persistent B. burgdorferi infection in vivo.

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Section: Discussionmentioning

confidence: 99%

Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi

et al. 2018

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“…The bacterial and fungal suspensions were uniformly inoculated on the surface of the culture media distributed in Petri dishes. Sterile cylinders, made of stainless steel, with a height of 10 mm and an inside diameter of 5 mm, were deposited on the surface of the sown plates [6,9]. The samples to be analysed, obtained by dissolving the substances in DMSO at a concentration of 25 µg/mL, were deposited inside the sterile cylinders in volume of 100 µL, the final tested concentration being of 2.5 µg.…”

Section: Evaluation Of the Antimicrobial Potential Of New Isoniazid Derivativesmentioning

confidence: 99%

New Isoniazid Derivatives for Antimicrobial Spectrum Extension and Hepatotoxicity Reduction of Parent Compound: In Vitro and in Vivo Assays

Dragostin¹

2020

FARMACIA

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One of the most common adverse effects, in the case of medicines used voluntarily or not, of over dosage, or even of drugs administered in therapeutic doses, is hepatic injury, which is why, in the pharmaceutical research, the experimental compounds are assessed before and during clinical trials, so that only compounds that prove to be safe for commercial use will be approved. In our case, compounds obtained prior to this study were evaluated from a biological point of view, following in vitro tests, establishing the antimicrobial potential, on bacterial strains and fungal strains. In addition, in vivo tests were performed on mice, for completing the pharmacotoxicological profile: evaluation of the hepatic markers (GPT, GOT, alkaline phosphatase, total serum cholesterol and serum albumin). The results demonstrate that different structural modulations of isoniazid can favourably influence the antimicrobial activity and may lead to an improvement of liver markers, after oral administration. RezumatUnul dintre cele mai frecvente efecte adverse, în cazul medicamentelor utilizate în mod voluntar sau nu, a unei doze excesive, sau chiar a medicamentelor administrate în doze terapeutice, este lezarea hepatică, motiv pentru care, în cercetarea farmaceutică, compușii experimentali sunt evaluați înainte și în timpul studiilor clinice, astfel încât doar cei care se dovedesc a fi siguri pentru utilizare, vor fi aprobați. În cazul nostru, compușii obținuți anterior acestui studiu, au fost evaluați din punct de vedere biologic, prin teste in vitro, stabilind potențialul antimicrobian, pe tulpini bacteriene și tulpini fungice. În plus, testele in vivo efectuate pe șoareci de laborator, au fost realizate pentru completarea profilului farmacotoxicologic: evaluarea markerilor hepatici (TGP, TGO, fosfatază alcalină, colesterol seric total și albumină serică). Rezultatele obținute demonstrează că diferitele modificări structurale ale izoniazidei pot influența în mod favorabil activitatea antimicrobiană ș i pot duce la o îmbunătățire a markerilor hepatici, după administrarea pe cale orală.

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“…The test results of antibacterial effect of zinc zeolite toothpaste are shown in table 3. According to literature [5,11], the Staphylococcus aureus and Escherichia coli antibacterial rate can reach 99.9% when the zinc zeolite mass fraction exceeds 2%. The quality score of the sample toothpaste zinc zeolite is 5%.…”

Section: Antibacterial Effect Of Zinc Zeolite Toothpastementioning

confidence: 99%

Study on the Application of Zinc-zeolite in Cosmetic Toothpaste

Di-fang¹,

Chun-sheng²

2019

AJCHE

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Beauty toothpaste, which can whiten teeth and refresh breath, is becoming more and more popular in the market. This paper studies the feasibility of applying zinc zeolite in toothpaste, including the preparation method of zinc zeolite toothpaste, quality index test, bacteriostasis test, stain removal test and halitosis reduction test. The results show that the quality of zinc zeolite toothpaste meets the requirements of china national standards. The bacteriostasis rate of 5% zinc zeolite toothpaste to Staphylococcus aureus and Escherichia coli can reach 99.9%. Zinc zeolite toothpaste has obvious effect of removing stains and halitosis. The conclusion of this paper is that zinc zeolite toothpaste is a safe and effective cosmetic toothpaste, which can be produced in batches.

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The Synergistic Antioxidant Effect and Antimicrobial Efficacity of Propolis, Myrrh and Chlorhexidine as Beneficial Toothpaste Components

Cited by 7 publications

References 7 publications

Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi

Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi

New Isoniazid Derivatives for Antimicrobial Spectrum Extension and Hepatotoxicity Reduction of Parent Compound: In Vitro and in Vivo Assays

Study on the Application of Zinc-zeolite in Cosmetic Toothpaste

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