The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of Overweight/Obese Adults with NAFLD

Chiurazzi, Martina; Cacciapuoti, Nunzia; Lauro, Mariastella Di; Nasti, Gilda; Ceparano, Margherita; Salomone, Elisabetta; Guida, Bruna; Lonardo,

doi:10.3390/nu14224750

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…Among them, 253 studies were excluded, including 51 studies in which the control group received other drugs, 16 studies which were non-RCTs, 13 studies in which no indicators were related to NAFLD, 79 studies in which the control group had other liver diseases, 74 studies which were reviews, and 20 studies which had incomplete data. In the end, 43 studies ( Pugh et al, 2013 ; Pugh et al, 2014 ; Abenavoli et al, 2015 ; Hallsworth et al, 2015 ; Dong et al, 2016 ; Panahi et al, 2016 ; Rahmani et al, 2016 ; Zhang et al, 2016 ; Abenavoli et al, 2017 ; Cheng et al, 2017 ; Houghton et al, 2017 ; Manzhalii et al, 2017 ; Misciagna et al, 2017 ; Navekar et al, 2017 ; Panahi et al, 2017 ; Dinu et al, 2018 ; Katsagoni et al, 2018 ; Wong et al, 2018 ; Ahn et al, 2019 ; Cai et al, 2019 ; Chashmniam et al, 2019 ; Ghaffari et al, 2019 ; Ghetti et al, 2019 ; Mirhafez et al, 2019 ; Saadati et al, 2019 ; Campanella et al, 2020 ; Cicero et al, 2020 ; Hariri et al, 2020 ; Nourian et al, 2020 ; Saberi-Karimian et al, 2020 ; Çevik Saldiran et al, 2020 ; Chong et al, 2021 ; Mirhafez et al, 2021 ; Mohamad Nor et al, 2021 ; Alami et al, 2022 ; Asghari et al, 2022 ; Chiurazzi et al, 2022 ; George et al, 2022 ; Khodami et al, 2022 ; Li et al, 2022 ; Mobasheri et al, 2022 ; Yurtdaş et al, 2022 ; Ezpeleta et al, 2023 ) were included in the NMA. The selection process is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis

Wang

Jin²,

Li³

et al. 2023

Front. Pharmacol.

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Background: With the increasing prevalence of obesity and metabolic syndrome, the incidence of non-alcoholic fatty liver disease (NAFLD) is also increasing. In the next decade, NAFLD may become the main cause of liver transplantation. Therefore, the choice of treatment plan is particularly important. The purpose of this study was to compare several interventions in the treatment of NAFLD to provide some reference for clinicians in selecting treatment methods.Methods: We searched Public Medicine (PubMed), Medline, Excerpta Medica Database (Embase), and Cochrane Library from January 2013 to January 2023 to identify randomized controlled trials (RCTs) published in English. The network meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Forty-three studies accounting for a total of 2,969 patients were included, and alanine aminotransferase (ALT), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) were selected as outcome measures for analysis and comparison.Results: We evaluated the results of drug, diet, and lifestyle interventions between the intervention and control groups. Curcumin (CUN) and probiotics (PTC) were selected for medication, the Mediterranean diet (MDED) was selected for special diet (SPD), and various kinds of exercise and lifestyle advice were selected for lifestyle interventions (LFT). The SUCRA was used to rank interventions according to the effect on ALT indicators (SUCRA: PTC 80.3%, SPD 65.2%, LFT 61.4%, PLB 32.8%, CUN 10.2%), TC indicators (SUCRA: PTC 89.4%, SPD 64%, CUN 34%, LFT 36.6%, PLB 17%), and LDL indicators (SUCRA: PTC 84.2%, CUN 69.5%, LFT 51.7%, PLB 30.1%, SPD 14.5%). The pairwise meta-analysis results showed that MDED was significantly better than NT in improving ALT [SMD 1.99, 95% CI (0.38, 3.60)]. In terms of improving TC and LDL, ATS was significantly better than NT [SMD 0.19, 95% CI (0.03, 0.36)] [SMD 0.18, 95% CI (0.01, 0.35)].Conclusion: Our study showed that PTC is most likely to be the most effective treatment for improving NAFLD indicators. Professional advice on diet or exercise was more effective in treating NAFLD than no intervention.

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Section: Resultsmentioning

confidence: 99%

Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis

Wang

Jin²,

Li³

et al. 2023

Front. Pharmacol.

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“…One of the first definitions of the Mediterranean diet was provided by Willet et al who asserted that the Mediterranean diet reflects the typical eating patterns of some regions of Greece and Italy in the early 1960s, where the adult’s life expectancy was remarkably high, while the rates of diet-related chronic disease were low [ 99 ••]. Several studies, indeed, over the years, have shown that the adoption of the MedDiet can protect against diseases, such as obesity, cardiovascular disease, type 2 diabetes (T2D), and non-alcoholic fatty liver disease (NAFLD) [ 100 , 101 ].…”

Section: Dietary Models and Pcosmentioning

confidence: 99%

Section: Dietary Models and Pcosmentioning

confidence: 99%

“…The beneficial mechanisms of MedDiet involve the reduction of inflammatory and oxidative stress markers and the improvement of lipid profiles, insulin sensitivity, and endothelial function, as well as antiatherosclerotic and antithrombotic properties [ 100 , 101 ]. Furthermore, MedDiet is also considered the best dietary model for the primary prevention of MetS [ 101 ]. Considering the close relationship between PCOS and obesity, low-grade chronic inflammation, and IR, MedDiet represents one of the optimal non-drug strategies for the PCOS treatment.…”

Section: Dietary Models and Pcosmentioning

confidence: 99%

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Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review

Di Lorenzo,

Cacciapuoti,

Lonardo

et al. 2023

Curr Nutr Rep

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Purpose of Review Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age worldwide. This disease causes menstrual, metabolic, and biochemical abnormalities such as hyperandrogenism, oligo-anovulatory menstrual cycles, polycystic ovary, hyperleptinemia, insulin resistance (IR), and cardiometabolic disorders, often associated with overweight or obesity and visceral adiposity. Recent Findings The etiology and pathophysiology of PCOS are not yet fully understood, but insulin seems to play a key role in this disease. PCOS shares an inflammatory state with other chronic diseases such as obesity, type II diabetes, and cardiovascular diseases; however, recent studies have shown that a healthy nutritional approach can improve IR and metabolic and reproductive functions, representing a valid therapeutic strategy to ameliorate PCOS symptomatology. Summary This review aimed to summarize and collect evidence about different nutritional approaches such as the Mediterranean diet (MedDiet) and the ketogenic diet (KD), as well as bariatric surgery and nutraceutical supplementation as probiotics, prebiotics, and synbiotics, among the others, used in patients with PCOS.

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“…Witamina E, L-glutation oraz sylimaryna wykazują działanie przeciwutleniające, przeciwzapalne oraz hepatoprotekcyjne. Wykazano, że stosowanie tych suplementów wraz z dietą śródziemnomorską może stanowić ważny element terapii u pacjentów z NAFLD [28].…”

Section: Dieta śRódziemnomorska a Nafldunclassified

Effect of mediterranean diet on non-alcoholic fatty liver disease (NAFLD)

Patrycja¹,

Walczak²,

Sylwia³

et al. 2023

J Educ Health Sport

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Introduction and purpose of the work: Non-alcoholic fatty liver disease (NAFLD) is a common condition in the general population. In its course, excessive fatty acids are deposited in liver cells. The best way to prevent it is to reduce weight by being physically active and eating a proper low-calorie diet. The purpose of this study is to describe the potential health benefits of the mediterranean diet in people with NAFLD. For this purpose, the literature available in the PubMed database was reviewed using the following keywords: mediterranean diet; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (MASH). State of the knowledge: The mediterranean diet is rich in fruits, vegetables, nuts, fish, olive oil and whole-grain products. It has the effect of decreasing insulin resistance, which is a major cause of NAFLD. In addition, it exerts anti-inflammatory and antioxidant properties. In recent years, numerous clinical studies have been conducted analyzing the effects of this diet on laboratory results, liver steatosis and progression to steatohepatitis (MASH) in patients with NAFLD. Conclusions: The results of the studies show that following a mediterranean diet can prevent as well as alleviate the course of this disease. However, there is a need for more clinical studies, on larger groups of people to recognize the mediterranean diet as an effective form of NAFLD therapy.

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The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of Overweight/Obese Adults with NAFLD

Cited by 6 publications

References 48 publications

Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis

Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis

Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review

Effect of mediterranean diet on non-alcoholic fatty liver disease (NAFLD)

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