The syndrome of inappropriate secretion of antidiuretic hormone associated with SCT: clinical differences following SCT using cord blood and BM/peripheral blood

Suzuki, Yamato; Kobayashi, Ryōji; Iguchi, Akihiro; Satô, Tomonobu; Kaneda, Makoto; Kobayashi, Kosaku; Ariga, Tadashi

doi:10.1038/bmt.2008.247

Cited by 11 publications

(15 citation statements)

References 26 publications

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“…In approximately half of these cases, hyponatremia develops due to syndrome of inappropriate antidiuretic hormone ( ADH ) secretion (SIADH) (1,2). The general causes of SIADH include central nervous system infection (3), malignancies, such as leukemia and lymphoma (4), and drugs, such as chemotherapeutics and antiepileptic agents (5).…”

Section: Introductionmentioning

confidence: 99%

Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Tacrolimus Following Allogeneic Cord Blood Transplantation

et al. 2013

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Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important electrolyte abnormality that can occur following allogeneic stem cell transplantation. We herein report the case of a 20-year-old man who developed SIADH three weeks after undergoing cord blood transplantation. Tacrolimus administration was suspected to be a cause of the disorder. In addition to restricting water intake and administering hypertonic sodium, the tacrolimus dosage was reduced, resulting in alleviation of SIADH. Therefore, tacrolimus should be recognized as an important, albeit rare, cause of drug-induced SIADH, even in patients with tacrolimus blood concentrations within the normal range. We believe that dose reduction, not discontinuation, is an effective strategy.

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Section: Introductionmentioning

confidence: 99%

Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Tacrolimus Following Allogeneic Cord Blood Transplantation

et al. 2013

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“…SIADH is one of the complications after SCT. 8,9,[18][19][20][21] Our previous report 8 revealed that SIADH was observed in 11.4% of pediatric patients after SCT. Risk factors for SIADH discussed in that report 8 included young age, transplantation from an HLA-mismatched or HLA-unrelated donor, CBT, and GVHD prophylaxis with methylprednisolone.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, neurological sequelae were more frequent after SCT in survivors with SIADH than that in those without SIADH. 9 However, the cause of SIADH after SCT remains unclear. In the current study, HHV6 reactivation was observed more frequently in patients with SIADH than in those without SIADH.…”

Section: Discussionmentioning

confidence: 99%

“…7 We previously reported that syndrome of inappropriate antidiuretic hormone secretion (SIADH) also seems to be one of the complications of SCT. 8,9 In that study, 16 of 140 pediatric patients who had undergone SCT were later diagnosed with SIADH. Multivariable analysis revealed that an age below 4 years and transplantation from an HLA-mismatched donor were particularly the risk factors for SIADH.…”

mentioning

confidence: 97%

“…In addition, neurological sequelae were more frequent after SCT in survivors with SIADH than in those without SIADH. 9 In this study, we investigated the incidence of HHV6 reactivation after SCT in pediatric patients and have evaluated its association with SIADH after SCT.…”

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confidence: 99%

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Risk Factors for Human Herpesvirus 6 Reactivation and its Relationship With Syndrome of Inappropriate Antidiuretic Hormone Secretion After Stem Cell Transplantation in Pediatric Patients

Toriumi

Kobayashi

Yoshida

et al. 2014

Journal of Pediatric Hematology/Oncology

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There have been several reports on the reactivation of human herpesvirus 6 (HHV6) after stem cell transplantation (SCT) in adults, which sometimes induces severe illness. Few reports exist on pediatric patients; therefore, we retrospectively examined HHV6 reactivation after SCT in children. We reviewed 80 patients with a median age of 6 years. We analyzed HHV6 DNA serum samples from the patients before SCT and at 20 and 40 days after SCT using polymerase chain reaction. We also analyzed the relationship between HHV6 reactivation and the syndrome of inappropriate antidiuretic hormone secretion (SIADH). At 20 days after SCT, 35.0% of serum samples were positive for HHV6 DNA. The median viral load was 3.1×10 copies/mL serum. Multivariate analysis showed cord blood transplantation as the only risk factor for HHV6 reactivation. HHV6 reactivation occurs in 59.4% of 32 patients who underwent cord blood transplantation and in 18.8% of 48 patients who underwent SCT from other sources. Among the 14 patients with SIADH, 78.6% experienced HHV6 reactivation. Among the 66 patients without SIADH, only 25.8% had HHV6 reactivation. This result was statistically significant (P<0.001). This analysis revealed that HHV6 reactivation occurs in many children. In addition, HHV6 reactivation plus SIADH should prompt evaluation for central nervous system disease.

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Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis

et al. 2017

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Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. We retrospectively evaluated the clinical significance of hyponatremia in cases of HHV-6 encephalitis/myelitis. Using an institutional database and medical records, we identified and retrospectively analyzed 16 cases of HHV-6 encephalitis and/or myelitis after allogeneic HSCT. HHV-6 encephalitis and myelitis were defined as the symptoms/signs with HHV-6-DNA in the cerebrospinal fluid. Seizure and memory disorder were defined as symptoms/signs of encephalitis, and dysesthesia and vesicorectal disorder as those of myelitis. Five patients developed encephalitis with or without myelitis, and 11 patients developed myelitis alone. Hyponatremia (median 129.1 mEq/L; range 125.9-130.1) was observed in all five patients with HHV-6 encephalitis at diagnosis, and values were significantly lower than those in patients with HHV-6 myelitis alone (median 137.6; range 134.0-142.2; P < 0.01). In three of the five patients with encephalitis, the decrease in sodium level preceded the clinical onset of encephalitis by one or two days. These results suggest that hyponatremia may be an important manifestation of HHV-6 encephalitis, but not of myelitis, and could be a useful tool for the early prediction or diagnosis of HHV-6 encephalitis.

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The syndrome of inappropriate secretion of antidiuretic hormone associated with SCT: clinical differences following SCT using cord blood and BM/peripheral blood

Cited by 11 publications

References 26 publications

Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Tacrolimus Following Allogeneic Cord Blood Transplantation

Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Tacrolimus Following Allogeneic Cord Blood Transplantation

Risk Factors for Human Herpesvirus 6 Reactivation and its Relationship With Syndrome of Inappropriate Antidiuretic Hormone Secretion After Stem Cell Transplantation in Pediatric Patients

Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis

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