The synchronization among nozzle extrusion, nozzle speed and rotating speed based on 3D vessel bioprinter

Liu, Huanbao; Zhou, Huixing; Chairinnas,

doi:10.1109/ica.2016.7811494

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…Liu et al [ 61 ] fabricated a bioprinter for the manufacture of artificial vessels, which was later adapted with a multi-nozzle multi-channel deposition system that could control the temperature (2–45

C) and the applied pressure (0.1–1 MPa). The nozzle precisely controlled these parameters, so it showed good performance in printing thermosensitive materials.…”

Section: Cardiovascular Tubular Applicationsmentioning

confidence: 99%

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

2020

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Bioresorbable cardiovascular applications are increasing in demand as fixed medical devices cause episodes of late restenosis. The autologous treatment is, so far, the gold standard for vascular grafts due to the similarities to the replaced tissue. Thus, the possibility of customizing each application to its end user is ideal for treating pathologies within a dynamic system that receives constant stimuli, such as the cardiovascular system. Direct Ink Writing (DIW) is increasingly utilized for biomedical purposes because it can create composite bioinks by combining polymers and materials from other domains to create DIW-printable materials that provide characteristics of interest, such as anticoagulation, mechanical resistance, or radiopacity. In addition, bioinks can be tailored to encounter the optimal rheological properties for the DIW purpose. This review delves into a novel emerging field of cardiovascular medical applications, where this technology is applied in the tubular 3D printing approach. Cardiovascular stents and vascular grafts manufactured with this new technology are reviewed. The advantages and limitations of blending inks with cells, composite materials, or drugs are highlighted. Furthermore, the printing parameters and the different possibilities of designing these medical applications have been explored.

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C) and the applied pressure (0.1–1 MPa). The nozzle precisely controlled these parameters, so it showed good performance in printing thermosensitive materials.…”

Section: Cardiovascular Tubular Applicationsmentioning

confidence: 99%

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

2020

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“…In order to realize the reconstruction of vessel-like structures and avoid the phenomenon of material accumulation and material dispersion, the theoretical model can be obtained by this rotary printing device, which is given that [28]

\vec{V_{3}} = \vec{V_{1}} + \vec{V_{2}}

…”

Section: Theorymentioning

confidence: 99%

“…Gao, Q. et al [27] have adopted the rotary printing method to fabricate vessel-like structures; it can proven that this method can improve the cell survival rate. Meanwhile, Liu, H. et al [28,29] have adopted the rotary printing method to obtain vessel-like structures and analyzed the synchronization among nozzle extrusion, nozzle speed, and rotating speed based on an extrusion-based 3D bioprinter, which could improve the modeling effect in this forming method.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin

et al. 2017

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3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineering and organ regeneration. In this paper, we have developed a novel rotary forming device, prepared an alginate–gelatin solution for the fabrication of vessel-like structures, and further proposed a theoretical model to analyze the parameters of motion synchronization. Using this rotary forming device, we firstly establish a theoretical model to analyze the thickness under the different nozzle extrusion speeds, nozzle speeds, and servo motor speeds. Secondly, the experiments with alginate–gelatin solution are carried out to construct the vessel-like structures under all sorts of conditions. The experiment results show that the thickness cannot be adequately predicted by the theoretical model and the thickness can be controlled by changing the parameters. Finally, the optimized parameters of thickness have been adjusted to estimate the real thickness in 3D printing.

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“…The cross-linking agent and the bio-ink will be printed respectively as inner sacrificing core and outer encapsulating shell, so that a self-supporting tubular structure can be formed. Liu et al [25] developed a set of auxiliary printing device that allow the bio-ink directly be dispensed onto a rotating rod to form a hollow tube. The rotary rod serves as a temporary support and it will be removed once the hollow tube is rigid enough to self-support.…”

Section: Introductionmentioning

confidence: 99%

“…The researchers from China Agricultural University (CAU) have successfully implemented this hybrid printing method in producing artificial blood vessels with a diameter of around 10 mm [25]. This paper will detail the setup of this bio-printer including the description of the key components and bio-ink properties in section 2.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the co-axial dispensing nozzle of a 3D bioprinter for the fabrication of tubular structures with micro-channel encapsulation

Xiong

Chen

Jia

et al. 2021

J. Micromech. Microeng.

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The 3D bio-printing has been developed as an effective approach to artificially create tubular tissue structures, which have been frequently found in body and organ systems. China Agricultural University (CAU) has developed a laboratory 3D bio-printer that can create tubular structures with the encapsulation of microfluidic channel. In order to create a tubular structure with more effective micro-channel encapsulation for better nutrient delivery and chemical stimulation, this work presents a design optimization of co-axial dispensing nozzle of this 3D bio-printer. In this study, an experimentally validated two-phase flow computational fluid dynamics modeling tool based on ANSYS CFX has been developed to analyze the microfluidic domain of fluid channels inside the nozzle. The simulations on the extrusion and encapsulation process of bio-inks have been conducted. Based on the response surface method, the simulation work has established an equation to predict the volume fraction of the encapsulating layer against a variety of influencing factors including the size of extrusion nozzle, pneumatic pressure condition and the dynamic viscosity of the bio-ink. This equation has been used to recommend optimal solutions of printing parameters for the CAU bio-printer, which is expected to improve the quality of bio-printed tubular structure with an encapsulation.

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The synchronization among nozzle extrusion, nozzle speed and rotating speed based on 3D vessel bioprinter

Cited by 4 publications

References 9 publications

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin

Optimization of the co-axial dispensing nozzle of a 3D bioprinter for the fabrication of tubular structures with micro-channel encapsulation

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