The synaptic excitation of Renshaw cells

Curtis, D. R.; Ryall, R. W.

doi:10.1007/bf00234362

Cited by 105 publications

(45 citation statements)

References 26 publications

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“…Moreover, VGLUT1-IR presynaptic vesicle clusters on V1-IaINs grow significantly larger than those on RCs, in agreement with previous electron microscopy observations indicating that the synaptic apparatus of VGLUT1-IR boutons partially regresses on RC dendrites from P15 to adult (Mentis et al, (Hultborn et al, 1971(Hultborn et al, , 1976Jankowska, 1992). In contrast, similar studies in the cat concluded that adult RCs lack monosynaptic activation by Ia or any other dorsal root afferent (Renshaw, 1946;Curtis and Ryall, 1966;Ryall et al, 1972; but see also Frank and Fuortes, 1956). Thus, monosynaptic activation of RCs by sensory afferents appears to be restricted to neonates (Mentis et al, 2006) and at this stage this input already shows quantitative differences in bouton density compared to IaINs.…”

supporting

confidence: 87%

“…Indeed, Ia afferents elicit relatively large monosynaptic EPSPs on adult cat spinal IaINs and evoke firing in these neurons more consistently and effectively than on other interneurons, at both low and high stimulation frequencies (Hultborn et al, 1971(Hultborn et al, , 1976Jankowska, 1992). In contrast, similar studies in the cat concluded that adult RCs lack monosynaptic activation by Ia or any other dorsal root afferent (Renshaw, 1946;Curtis and Ryall, 1966;Ryall et al, 1972; but see also Frank and Fuortes, 1956). Thus, monosynaptic activation of RCs by sensory afferents appears to be restricted to neonates (Mentis et al, 2006) and at this stage this input already shows quantitative differences in bouton density compared to IaINs.…”

Section: Discussionmentioning

confidence: 98%

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Target selection of proprioceptive and motor axon synapses on neonatal V1‐derived Ia inhibitory interneurons and Renshaw cells

Siembab

Smith

Zagoraiou

et al. 2010

J of Comparative Neurology

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The diversity of premotor interneurons in the mammalian spinal cord is generated from a few phylogenetically conserved embryonic classes of interneurons (V0, V1, V2, V3). Their mechanisms of diversification remain unresolved, although these are clearly important to understand motor circuit assembly in the spinal cord. Some Ia inhibitory interneurons (IaINs) and all Renshaw cells (RCs) derive from embryonic V1 interneurons; however, in adult they display distinct functional properties and synaptic inputs, for example proprioceptive inputs preferentially target IaINs, while motor axons target RCs. Previously, we found that both inputs converge on RCs in neonates, raising the possibility that proprioceptive (VGLUT1-positive) and motor axon synapses (VAChT-positive) initially target several different V1 interneurons populations and then become selected or deselected postnatally. Alternatively, specific inputs might precisely connect only with predefined groups of V1 interneurons. To test these hypotheses we analyzed synaptic development on V1-derived IaINs and compared them to RCs of the same age and spinal cord levels. V1-interneurons were labeled using genetically encoded lineage markers in mice. The results show that although neonatal V1-derived IaINs and RCs are competent to receive proprioceptive synapses, these synapses preferentially target the proximal somato-dendritic regions of IaINs and postnatally proliferate on IaINs, but not on RCs. In contrast, cholinergic synapses on RCs are specifically derived from motor axons, while on IaINs they originate from Pitx2 V0c interneurons. Thus, motor, proprioceptive, and even some interneuron inputs are biased toward specific subtypes of V1-interneurons. Postnatal strengthening of these inputs is later superimposed on this initial preferential targeting. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptThe development of spinal cord local interneuronal circuits is currently poorly understood. Recent work has defined a relatively small number of cardinal interneurons in embryo that generates the much larger diversity of adult interneurons (Goulding, 2009). In the ventral horn just four embryonic subgroups (V0, V1, V2, V3) generate most adult premotor interneurons by diversification mechanisms that are currently largely unknown. Each group displays common properties that generally include origins from one type of progenitor cell (p0, p1, p2, p3), the direction taken by the primary axon, their cell migration and final location in the ventral horn with relation to motor pools, and their neurotransmitter phenotype. For example, V1 interneurons have common origins in the p1 progenitor area and are characterized by expression of the engrailed-1 (En-1) transcription factor. They migrate ventrolaterally, positioning themselves adjacent to motor pools, extend ascending axons that target ipsilateral motoneurons, and have an inhibitory phenotype (Matise and Joyner, 1997; Ericsson et al., 1997;Saueressig et al., 1999;Sapir et al., 2004;Alvarez et a...

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supporting

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Target selection of proprioceptive and motor axon synapses on neonatal V1‐derived Ia inhibitory interneurons and Renshaw cells

Siembab

Smith

Zagoraiou

et al. 2010

J of Comparative Neurology

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“…DHI3E did not block excitation by DLH. It does not antagonize a muscarinic component of the excitatory action of acetyl-,-methylcholine (Curtis & Ryall, 1966b) and it facilitates the late discharge of Renshaw cells evoked by antidromic ventral root volleys (Curtis & Ryall, 1966c;Ryall, 1970). It was observed that atropine consistently and selectively blocked the excitatory action of ACh, leaving excitation by DLH unaffected (Figures 1, 2).…”

Section: Agonistsmentioning

confidence: 96%

“…The effect of atropine or methyl atropine on the early discharge to antidromic ventral root volleys (Curtis & Ryall, 1966c) was observed on 13 Renshaw cells. Figure 5 illustrates the result obtained in one experiment in which the effect of methyl atropine was the largest effect observed with either atropine or methyl atropine.…”

Section: Agonistsmentioning

confidence: 98%

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A Re‐evaluation of Acetylcholine Receptors on Feline Renshaw Cells

King

Ryall

1981

British J Pharmacology

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1 The effects of atropine, methylatropine and lachesine administered by ionophoresis were examined on responses of Renshaw cells to acetylcholine, acetyl-43-methylcholine, nicotine and DL-muscarine in cats anaesthetized with pentobarbitone or chloralose. 2 The antagonists were as effective in antagonizing excitation by nicotine as they were in antagonizing excitation by acetylcholine and were only slightly more effective in antagonizing excitation by acetyl-,3-methylcholine.

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Modulation of Cholinergic Transmission by Substance P

Ryall

1982

Novartis Foundation Symposia

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The synaptic excitation of Renshaw cells

Cited by 105 publications

References 26 publications

Target selection of proprioceptive and motor axon synapses on neonatal V1‐derived Ia inhibitory interneurons and Renshaw cells

Target selection of proprioceptive and motor axon synapses on neonatal V1‐derived Ia inhibitory interneurons and Renshaw cells

A Re‐evaluation of Acetylcholine Receptors on Feline Renshaw Cells

Modulation of Cholinergic Transmission by Substance P

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